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TPP1 Products

(Tripeptidyl Peptidase I (TPP1))

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This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].

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Featured TPP1 Categories

TPP1 Antibodies

High quality antibodies with extensive validation data.

TPP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

TPP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TPP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7435157
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7440935
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN560411
Quantity 100 μg
Datasheet Datasheet

Recommended TPP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970869
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960181
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6960182
Quantity 96 tests
Datasheet Datasheet

Recommended TPP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323447
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323446
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3074453
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TPP1 products

Assani, Yessoufou, Xiong, Segbo, Yu, Zhou, Zhou: "Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 20, Issue 6, pp. 1849-1856, (2019) (PubMed).

Brenneman, Pearce, Kovacs, DeFrees: "Pharmacological Effects on Ceroid Lipofuscin and Neuronal Structure in Cln3∆ex7/8Mouse Brain Cultures." in: Journal of molecular neuroscience : MN, Vol. 63, Issue 1, pp. 100-114, (2017) (PubMed).

Qing, Zhou, Zhao, Xie, Yang, Xing, Zeng, Jiang: "Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis." in: Rheumatology international, Vol. 32, Issue 8, pp. 2503-10, (2012) (PubMed).

Kousi, Siintola, Dvorakova, Vlaskova, Turnbull, Topcu, Yuksel, Gokben, Minassian, Elleder, Mole, Lehesjoki: "Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis." in: Brain : a journal of neurology, Vol. 132, Issue Pt 3, pp. 810-9, (2009) (PubMed).

Synonyms and alternative names related to TPP1

tripeptidyl peptidase I (tpp1), tripeptidyl-peptidase 1 (NAEGRDRAFT_78259), tripeptidyl-peptidase 1 (MCYG_00184), tripeptidyl-peptidase 1 (MGYG_05881), tripeptidyl-peptidase 1 (MGYG_00757), tripeptidyl peptidase 1 (tpp1), tripeptidyl peptidase 1 (TPP1), tripeptidyl peptidase 1 (Tpp1), tripeptidyl peptidase I (Tpp1), cln2, CLN2, Cln2, fa01b09, im:7149243, LPIC, TPP-1, TPP-I, wu:fa01b09

Protein level used designations for TPP1

  • ceroid-lipofuscinosis, neuronal 2
  • tripeptidyl-peptidase 1
  • cell growth-inhibiting gene 1 protein
  • growth-inhibiting protein 1
  • lysosomal pepstatin insensitive protease
  • tripeptidyl aminopeptidase
  • LPIC
  • TPP-1
  • TPP-I
  • lysosomal pepstatin-insensitive protease
  • tripeptidyl peptidase 1
  • tripeptidyl-peptidase I
  • tripeptidyl peptidase-I
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