TPR Products
(Nucleoprotein TPR (TPR))
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This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].
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TPR Antibodies
High quality antibodies with extensive validation data.
Recommended TPR Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN563243
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
Cat. No.
ABIN521068
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Rabbit
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN6746941
Quantity
100 μL
Datasheet
Datasheet
Recommended TPR Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323452
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TPR products
: "An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer." in: Cell, Vol. 167, Issue 7, pp. 1705-1718.e13, (2017) (PubMed).: "Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways." in: PLoS ONE, Vol. 10, Issue 8, pp. e0133699, (2015) (PubMed).
: "Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis." in: The Journal of cell biology, Vol. 203, Issue 6, pp. 883-93, (2014) (PubMed).
: "The interaction between importin-α and Nup153 promotes importin-α/β-mediated nuclear import." in: Traffic (Copenhagen, Denmark), Vol. 13, Issue 7, pp. 934-46, (2012) (PubMed).
: "Herpes simplex virus replication: roles of viral proteins and nucleoporins in capsid-nucleus attachment." in: Journal of virology, Vol. 83, Issue 4, pp. 1660-8, (2009) (PubMed).
: "Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production." in: Journal of virology, Vol. 81, Issue 14, pp. 7571-83, (2007) (PubMed).
: "Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31463-7, (1999) (PubMed).
Synonyms and alternative names related to TPR
translocated promoter region, nuclear basket protein (TPR), nuclear pore anchor (NUA), translocated promoter region, nuclear basket protein (Tpr), 2610029M07Rik, AtTPR, C77892, nuclear pore anchor, TRANSLOCATED PROMOTER REGION, YUP8H12R.12, YUP8H12R_12Protein level used designations for TPR
- translocated promoter region (to activated MET oncogene)
- NPC-associated intranuclear protein
- nuclear pore complex-associated protein Tpr
- nucleoprotein TPR
- translocated promoter region and nuclear basket protein
- megator
- nuclear pore complex-associated protein TPR
- translocated promoter region protein
- tumor potentiating region
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