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Human Monoclonal CP Primary Antibody for IHC (fro), IP - ABIN532657
Loeffler, Sima, LeWitt: Ceruloplasmin immunoreactivity in neurodegenerative disorders. in Free radical research 2001
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Human Polyclonal CP Primary Antibody for IHC, IHC (p) - ABIN4297774
Hametner, Wimmer, Haider, Pfeifenbring, Brück, Lassmann: Iron and neurodegeneration in the multiple sclerosis brain. in Annals of neurology 2014
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Human Polyclonal CP Primary Antibody for FACS, IHC (p) - ABIN391512
Jiang, Liu, Zheng, Chen, Maimaitiming, Chen, Liu, Jiang, Fuqua, Dunaief, Vulpe, Anderson, Wang, Chen: Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. in Scientific reports 2018
Human Polyclonal CP Primary Antibody for IHC (fro), ELISA - ABIN2472949
Perusicová, Fric, Cacáková, Mardesicová, Stolba, Kocna: [The effect of Sinecal fiber on compensation in type 2 diabetics]. in Vnitr?ní lékar?ství 1990
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Human Polyclonal CP Primary Antibody for IHC (fro), ELISA - ABIN2472948
Mazumder, Sampath, Fox: Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control. in Molecules and cells 2005
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this study shows that heterotopic production of ceruloplasmin by lung adenocarcinoma is significantly correlated with prognosis
cerulosplamin may be a marker of relapse and transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision in Paracoccidioidomycosis.
MIR520D elevated serum levels in Parkinson's disease patients is associated with ceruloplasmin gene expression.
ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients
Maternal blood ceruloplasmin level was found to be lower in neural tube defect-affected pregnancies as compared to healthy controls.
Increased serum transferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes has been reported.
Strong correlations between the meconium concentrations of CP, LF and MPO indicate a possible role of these complementary proteins in maintaining homeostasis of the intrauterine environment of the fetus. CP, LF and MPO measured in meconium may serve as biomarkers for assessment of impairment of oxidative balance during intrauterine life with its potential impact on disease development in adulthood.
A woman in her 50s who initially presented with movement disorder was diagnosed with aceruloplasminemia, a rare autosomal recessive disorder resulting in accumulation of iron deposits in major organs. Genetic testing confirmed mutations in the ceruloplasmin gene (c.1864 + 1G>C).
Higher circulating ceruloplasmin levels were associated with increased atrial fibrillation risk.
for ATP7B mutations, the more severe impact on ATP7B protein was, the younger onset age and lower Cp level presented. The feasibility of presymptomatic DNA diagnosis and predicting clinical manifestation or severity of Wilson disease (WD) would be facilitated with identified mutations and genotype-phenotype correlation precisely revealed in the study.
Ceruloplasmin is supposed to be related with advanced T stage and perineural invasion, having a possibility as a candidate prognostic marker for bile duct cancer.
Mechanistically, ceruloplasmin could specifically interact with the hepatitis B virus middle surface protein.
The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units.
Ceruloplasmin was independently and negatively associated with liver fibrosis in chronic hepatitis b.
Coronary atherosclerosis is distinguished by serum C4 complement up-regulation and ceruloplasmin down-regulation.
Data show that the concentration of ceruloplasmin (ferroxidase; Cp) was significantly higher in Low hemoglobin (Hb) compared to High Hb subsample.
serum ceruloplasmin level was lower in the primary open-angle glaucoma group in comparison to the group with only cataract.
The determination of serum ceruloplasmin in adolescents might be a useful tool to identify patients with the highest risk of future cardiovascular disease.
The main result of this study is that ceruloplasmin specific activity is associated with a decreased risk of developing Alzheimer's disease
pathological cerebrospinal fluid's environment of Parkinson's disease patients promoted the same modifications in the exogenously added ceruloplasmin
HEPH and CP are not essential for intestinal iron absorption but are required for proper systemic iron distribution.
results suggest that ablation of hephaestin and ceruloplasmin could lead to severe systemic iron deficiency and local tissue iron overload, which disrupt the whole body iron homeostasis and impact on tissue functions
Ceruloplasmin regulates reelin processing, cofilin phosphorylation and neuronal organization in the developing brain.
Results show that both HEPH and CP are expressed in subcutaneous adipose tissue. Ablation of either MCF leads to a compensatory increase in the other, which contributes to the balance of iron status. However, ablation of both induces severe iron deposition in adipocytes and displays disordered carbohydrate metabolism characterized as type 2 diabetes.
We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice and Heph/Cp double-knockout mice to investigate the roles of multicopper ferroxidases(MCF) in pancreatic iron homeostasis. We found that both HEPH and CP were expressed in the mouse pancreas, and that ablation of either MCF had limited effect on the pancreatic iron levels.
Hephaestin and ceruloplasmin have roles in facilitating iron metabolism in the mouse kidney
In D-galactosamine-sensitized mice CP+Cu(II) increased the LPS-induced lethality from 54 to 100%, while administration of antibodies against MIF prevented the lethal effect. The enhancement by CP+Cu(II) of the pro-inflammatory signal of MIF is discussed
mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator.
Data (including data from studies in knockout mice) suggest that ceruloplasmin and hephaestin play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis.
an increase in Cp expression could contribute to tissue damage in early experimental autoimmune encephalomyelitis
Evidence supports a regulatory role of both proteins (Ceruloplasmin (CP) and beta-amyloid protein precursor (APP)) in defence against iron-induced oxidative damage after TBI, which presents as a tractable therapeutic target.
Genetic interactions between Cp, Mon1a, and the Slc40a1 locus are involved in iron metabolism.
ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase during inflammation
The mouse ceruloplasmin gene has been mapped to chromosome 3.
Data found an increase in ceruloplasmin levels in the plasma of Npc1 -/- mice compared to Npc1 +/+ mice, and this increase was statistically significant (*p < 0.05).
Cp and Heph are necessary for iron export from the retina but are not essential for iron import into the retina.
levels of 5HT and norepinephrine and the expression of BDNF and its receptor trkB, are significantly reduced in the hippocampus of ceruloplasmin knockout mice
Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke.
Atp7b(-/-) mice demonstrated decreased serum iron parameters and hemoglobin levels most likely related to a low serum ceruloplasmin oxidase activity and not due to total body iron deficiency.
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
, hypothetical protein
, ceruloplasmin (ferroxidase)