VENTX1.2 Proteins
(VENT Homeobox 1, Gene 2 (VENTX1.2))
Transcriptional repressor. Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation. Acts downstream of bmp4 to repress transcription of foxa4-B/XFD-1'. Binds to DNA with preference for the target sequence 5'-CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene and represses myf5 transcription in the ventral domain.
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Recommended VENTX1.2 Proteins
Synonyms and alternative names related to VENTX1.2
VENT homeobox 1, gene 2 S homeolog (ventx1.2.S), vent-1, vent1, xvent-1Protein level used designations for VENTX1.2
- homeobox protein vent1
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