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This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.
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Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C (show HTR2C Antibodies) receptors in the choroid plexus of the primate brain.
found enrichment of serotonin receptor 2A mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT2A receptor agonists on responses of V1 neurons.
SMC (show DYM Antibodies)-rich intima as well as media directly contributes to the hypercontractile response of atherosclerotic vessels through the 5-HT(2A) receptor and the Rho-kinase (show ROCK1 Antibodies) pathway
Study showed that acute stress activates 5-HT2AR expression in the mouse cortex and this activation requires the immediate early (show JUN Antibodies) gene Egr3 (show EGR3 Antibodies)
Whole-brain mapping and pharmacological screening indicated that serotonin-2A receptor (Htr2a)-expressing cells in the central amygdala (CeA (show CEA Antibodies)) control both innate and learned freezing, but in opposing directions
Study showed increased expression in striatum membranes and decreased expression in frontal cortex membranes for both DRD2 (show DRD2 Antibodies) and Htr2a from heterozygous Reelin (show RELN Antibodies) mutant mice compared to wild-type
Hippocampal mRNA expression of Htr2a is decreased in serotonin deficient mice after early life stress.
Involvement of 5-HT2 receptors in the expression of withdrawal diarrhea in morphine-dependent mice
Elevated whole-blood 5HT (show DDC Antibodies) or hyperserotonemia is a consistent finding in approximately 30% of autistic spectrum disorder individuals.
5-HT1A (show HTR1A Antibodies) and 5-HT2A receptors are able to modulate each other functional activity by means of bilateral functional cross-talk.
impact of the 5-HT2A and the 5-HT1A receptor (show CC2D1A Antibodies) for different serotonin syndrome-like responses
Translational and ecological study involving constitutive Htr2a(-/-) knock-out mice and related SNPs in depressed patients suggests that a lower neurotransmission at the 5-HT2AR may favor the susceptibility and severity of major depressive disorder
The results highlight a likely role of the 5-HT2 receptors in allergic airways disease and suggest that 5-HT2 receptor agonists may represent an effective and novel small molecule-based therapy for asthma.
According to the results obtained, no association between the analysed polymorphism of genes: 5HTR2A (T102C), SLC6A4 (5-HTTLPR (show SLC6A4 Antibodies)) and schizophrenia was found
5-HT(2) receptors are coupled to phospholipase C (show PLC Antibodies) in bovine ciliary epithelium.
analysis of eight bovine 5-HT receptor (show HTR7 Antibodies) subtypes in brain, abomasum, and intestine by real-time RT-PCR
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
The 5-HT 2A receptor seem to be particularly involved in antigen-induced airway hyperresponsiveness(AI-AHR (show AHR Antibodies)) to ACh (show FGFR3 Antibodies) in guinea-pigs.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
5-hydroxytryptamine (serotonin) receptor 2A
, 5-HT2A receptor
, 5-hydroxytryptamine receptor 2A
, serotonin receptor 2A
, 5-HT2a receptor
, 5-hydroxytryptamine 2 receptor
, serotonin 2 receptor