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Actin, Alpha, Cardiac Muscle 1 Proteins (ACTC1)

Actins are highly conserved proteins that are involved in various types of cell motility. Additionally we are shipping ACTC1 Antibodies (20) and ACTC1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACTC1 70 P68032
ACTC1 11464 P68033
ACTC1 29275 P68035
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Top ACTC1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Bovine Cow Un-conjugated   100 μg Log in to see 7 to 9 Days
$455.71
Details
Yeast Takifugu rubripes His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details

ACTC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Actin, Alpha, Cardiac Muscle 1 (ACTC1) Interaction Partners

Zebrafish Actin, Alpha, Cardiac Muscle 1 (ACTC1) interaction partners

  1. Studies indicate that The change in F-actin or G-actin (show ACTB Proteins) contents in a cell would translate to a number of biological endpoints such as change in cell shape, disrupted cell division, altered cell-cell adhesion, cell survival, and cell migration or motility.

Human Actin, Alpha, Cardiac Muscle 1 (ACTC1) interaction partners

  1. A heterozygous missense mutation was found (c.251T>C, p.(Met84Thr)) in the ACTC1 gene

  2. In this study, there was no association of the analyzed SNPs located in RASGRF1 (show RASGRF1 Proteins). GJD2 (show GJD2 Proteins), and ACTC1 with pathological myopia.

  3. In adult Hypertrophic Cardiomyopathy patients, thin-filament gene ACTC1 mutations are associated with increased likelihood of advanced Left Ventricular dysfunction and heart failure compared with thick-filament disease.

  4. Genetic variations at the ACTC1 gene may contribute to progression to chronic Chagas Cardiomyopathy

  5. Change in the ability of cMyBP-C to bind cardiac actin modified filaments might contribute to the development of disease.

  6. Our results provide further evidence supporting a causative role for ACTC1 mutations in ASD (show ARSD Proteins). Massively parallel sequencing of the exome allows for the detection of novel rare variants causing CHD (show CHDH Proteins) without the limitations of a candidate gene approach.

  7. The authors demonstrate that clathrin promotes clustering of the vaccinia virus actin tail nucleator A36 and host N-WASP (show WASL Proteins), which activates actin nucleation through the Arp2 (show ACTR2 Proteins)/3 complex.

  8. ACTC1 mutations Y166C and M305L are associated with hypertrophic cardiomyopathy

  9. Data show that HMGN2 inhibited the attachment of bacteria, and then decreased bacteria-induced ERK1/2 activation and actin polymerization, which might contribute to bacterial internalization into T24 cells.

  10. propose that the ACTC E99K mutation causes higher myofibrillar Ca(2 (show CA2 Proteins)+) sensitivity that is responsible for the sudden cardiac death, apical hypertrophy, and subsequent development of heart failure in humans and mice.

Mouse (Murine) Actin, Alpha, Cardiac Muscle 1 (ACTC1) interaction partners

  1. ACTC E361G mutation uncouples the relationship between Ca(2+) sensitivity and troponin I phosphorylation, predisposing the heart to dilated cardiomyopathy under conditions of chronic stress.

  2. results demonstrate that in ACTC(Co)/KO myofibres, the presence of cardiac alpha-actin instead of skeletal muscle alpha-actin alters actin conformational changes upon activation; this later finely modulates the strain of individual actomyosin interactions and overall lowers myofibre force production

  3. Data indicate that the tri-helix bundle is important to the regulatory role of cMyBP-C, likely through actin-binding interactions.

  4. propose that the ACTC E99K mutation causes higher myofibrillar Ca(2 (show CA2 Proteins)+) sensitivity that is responsible for the sudden cardiac death, apical hypertrophy, and subsequent development of heart failure in humans and mice.

  5. Other actin isoforms cannot compensate for the lack of cardiac alpha-actin (show ACTA2 Proteins), and this seems to induce apoptosis in defective cardiac myocytes, which are not able to cope with the increased workload in the perinatal phase.

  6. These results demonstrate the importance of the Emb (show EMB Proteins)-MEF2D (show MEF2D Proteins)-histone transacetylase p300 (show NOTCH1 Proteins) complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation.

  7. there is a cardiac-specific enhancer located within -2.354/-1.36 kbp of Actc1

Cow (Bovine) Actin, Alpha, Cardiac Muscle 1 (ACTC1) interaction partners

  1. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

ACTC1 Protein Profile

Protein Summary

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Gene names and symbols associated with ACTC1

  • actin, alpha, cardiac muscle 1 (actc1)
  • actin, beta-like 2 (ACTBL2)
  • actin, alpha, cardiac muscle 1 (ACTC1)
  • actin, alpha, cardiac muscle 1b (actc1b)
  • actin, alpha 1, skeletal muscle (acta1)
  • actin, gamma 1 (ACTG1)
  • muscle actin OlMA1 (acta1)
  • actin, alpha 1, skeletal muscle (ACTA1)
  • actin, alpha, cardiac muscle 1 (Actc1)
  • hm:zewp0073 (hm:zewp0073)
  • ACTA protein
  • ACTA1 protein
  • acta2 protein
  • ACTC protein
  • Actc-1 protein
  • ACTC1 protein
  • ACTG1 protein
  • ASD5 protein
  • asma protein
  • cftd protein
  • cftd1 protein
  • cftdm protein
  • CMD1R protein
  • CMH11 protein
  • DKFZp468G072 protein
  • fa27h01 protein
  • fb83f06 protein
  • LVNC4 protein
  • MGC52636 protein
  • MGC79039 protein
  • MGC89192 protein
  • mpfd protein
  • nem1 protein
  • nem2 protein
  • nem3 protein
  • wu:fa27h01 protein
  • wu:fb83f06 protein
  • zewp0073 protein

Protein level used designations for ACTC1

Actin alpha 1 , Alpha-cardiac actin , actin, alpha cardiac muscle 1 , cardiac actin , cardiac alpha actin , actin, alpha, cardiac muscle 1 , B-actin , actin, alpha cardiac muscle 1-like , actin, alpha 1, skeletal muscle , alpha 1 skeletal muscle actin , actin, alpha 2, smooth muscle, aorta , actin, gamma 1 , actin, alpha skeletal muscle , olMA1 , alpha-actin-1 , Actin, alpha skeletal muscle , actin, alpha skeletal muscle-like , actin alpha cardiac , alpha-cardiac actin , alphac-actin , actin alpha cardiac 1 , actin, alpha, cardiac 1 , alpha-actin cardiac , actin alpha 1

GENE ID SPECIES
394698 Xenopus (Silurana) tropicalis
426652 Gallus gallus
453307 Pan troglodytes
478250 Canis lupus familiaris
697367 Macaca mulatta
100057678 Equus caballus
100158242 Sus scrofa
100398865 Callithrix jacchus
100442237 Pongo abelii
58114 Danio rerio
432314 Xenopus laevis
448346 Xenopus (Silurana) tropicalis
475923 Canis lupus familiaris
100049431 Oryzias latipes
100065454 Equus caballus
100172818 Pongo abelii
100395910 Callithrix jacchus
100426612 Macaca mulatta
100603570 Nomascus leucogenys
70 Homo sapiens
11464 Mus musculus
29275 Rattus norvegicus
533219 Bos taurus
423298 Gallus gallus
379752 Xenopus laevis
337770 Danio rerio
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