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The protein encoded by ACTA2 belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Additionally we are shipping Smooth Muscle Actin Kits (21) and Smooth Muscle Actin Proteins (10) and many more products for this protein.
Showing 10 out of 210 products:
Human Monoclonal Smooth Muscle Actin Primary Antibody for WB - ABIN396199
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 6 references for ABIN396199
Human Polyclonal Smooth Muscle Actin Primary Antibody for IHC, ELISA - ABIN185271
Reddy, Ozgur, Lu, Chang, Mohan, Kumar, Ruley: Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region. in The Journal of biological chemistry 1990
Show all 4 references for ABIN185271
Human Monoclonal Smooth Muscle Actin Primary Antibody for IF, ELISA - ABIN513087
Lino Cardenas, Henaoui, Courcot, Roderburg, Cauffiez, Aubert, Copin, Wallaert, Glowacki, Dewaeles, Milosevic, Maurizio, Tedrow, Marcet, Lo-Guidice, Kaminski, Barbry, Luedde, Perrais, Mari, Pottier: miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. in PLoS genetics 2013
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Human Monoclonal Smooth Muscle Actin Primary Antibody for ICC, FACS - ABIN968947
Shimojima, Yamamoto: ACTA2 is not a major disease-causing gene for moyamoya disease. in Journal of human genetics 2009
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Human Monoclonal Smooth Muscle Actin Primary Antibody for ICC, FACS - ABIN968945
Guo, Pannu, Tran-Fadulu, Papke, Yu, Avidan, Bourgeois, Estrera, Safi, Sparks, Amor, Ades, McConnell, Willoughby, Abuelo, Willing, Lewis, Kim, Scherer, Tung, Ahn, Buja, Raman, Shete, Milewicz: Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. in Nature genetics 2007
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Human Monoclonal Smooth Muscle Actin Primary Antibody for IHC, ELISA - ABIN968946
Salas, Bartoli, Deville, Gaudart, Fina, Calisti, Bollini, Curvale, Gentet, Duffaud, Figarella-Branger, Bouvier: Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. in Virchows Archiv : an international journal of pathology 2007
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Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
ACTA2 mutations are associated with structural disruption and functional impairment of contractile proteins, and predispose to a variety of diffuse vascular diseases including TAAD, CAD (show CAD Antibodies), ischemic strokes, and Moyamoya disease. Vascular SMCs are also implicated in vascular remodeling in both physiological and pathological conditions.
Parenchymal alphaSMA expression in hepatic tissue appeared to increase only among hepatitis C subjects with fibrosis 3-4.
Multisystemic smooth muscle dysfunction syndrome secondary to an ACTA2 mutation.
alpha-SMA expression, and MLC phosphorylation, whereas butaprost inhibited TGF-beta2-induced CPCG contraction, actin polymerization, and MLC phosphorylation.
Genetic analysis revealed a missense mutation of the ACTA2 gene, encoding for a smooth muscle isoform of alpha-actin.
NGF (show NGFB Antibodies) has a role in modulating trkANGFR/p75NTR (show NGFR Antibodies) in alphaSMA-expressing conjunctival fibroblasts from human ocular cicatricial pemphigoid
increased level of alphaSMA, a hallmark of epithelial mesenchymal transition in lens epithelial cells, is associated with increased level of histone H4 acetylation at the promoter region of alphaSMA gene(ACTA2)
Alpha-SMA (show SMN1 Antibodies) overexpression induced YAP (show YAP1 Antibodies) translocation to the nucleus and reduced the high clonogenicity and adipogenic potential of alpha-SMA (show SMN1 Antibodies)-negative MSCs.
The number and distribution of myofibroblasts and the expression levels of ACTA2 in the fetal membrane may be involved in the mechanisms of development, apoptosis and trophoblastmyofibroblast transformation of the fetal membrane.
All the variants analyzed expressed alpha-SMA (show SMN1 Antibodies) mildly or moderately, except for the follicular variant that either did not express alpha-SMA (show SMN1 Antibodies) or expressed it mildly.
Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta (show TGFB1 Antibodies)/SMADS signaling pathway and down-regulating TGF-beta1 (show TGFB1 Antibodies), SMAD2 (show SMAD2 Antibodies)/3, and alpha-SMA (show SMN1 Antibodies) expression.
The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 Antibodies) during scleral chondrogenesis accompany myopia development.
Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.
The results suggest that the expression level of TGF-b1 and a-SMA in stromal fibroblasts may have prognostic significance in patients with clinical stage I-IIIA NSCLC after curative resection
alphaSMA is a useful marker for further understanding the molecular and cellular characteristics of non-hematopoietic cells in the lymph nodes.
This in vitro expression study revealed the additional profibrotic role of IL-6 (show IL6 Antibodies) in fibroblast to myofibroblast transition and in alpha smooth muscle actin (show ACTG2 Antibodies) induction.
Data indicate that NRG-1beta up-regulated the gene expressions of Nkx2.5 (show NKX2-5 Antibodies), GATA4 (show GATA4 Antibodies), alpha-actin, MLC-2v (show MYL2 Antibodies), and ANF (show HESX1 Antibodies) in a time-dependent regulation of ErbB (show EGFR Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) pathways.
these studies identify a pathway that culminates in the post-transcriptional regulation of utrophin (show UTRN Antibodies) A through increases in mRNA stability.
sustained Akt1 (show AKT1 Antibodies)-induced alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin (show MYOCD Antibodies).
TnT has a previously unrecognized role in forming the inactive state of regulated actin.
The terminal pointed end subunit is tilted (show OTOP1 Antibodies) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.
There was no significant change in the expression of TGF-beta(2 (show TGFB2 Antibodies)) and alpha-SMA (show SMN1 Antibodies) after laser-assisted intrastromal scanning.
The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.
The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, alpha smooth muscle actin
, actin, alpha 2, smooth muscle, aorta
, actin alpha cardiac 1
, actin, aortic smooth muscle
, vascular smooth muscle alpha-actin
, alpha-smooth muscle actin
, actin, aortic smooth muscle-like
, alpha-cardiac actin
, cell growth-inhibiting gene 46 protein
, actin, alpha, vascular smooth muscle
, alpha actin 2
, smooth muscle alpha-actin
, alpha actin