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Actin, alpha 2, Smooth Muscle, Aorta Proteins (ACTA2)

The protein encoded by ACTA2 belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Additionally we are shipping Smooth Muscle Actin Antibodies (210) and Smooth Muscle Actin Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACTA2 59 P62736
ACTA2 11475 P62737
ACTA2 81633 P62738
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Top Smooth Muscle Actin Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Chicken His tag,T7 tag 100 μg Log in to see 9 to 11 Days
$683.10
Details
HOST_Wheat germ Human GST tag 25 μg Log in to see 9 Days
$591.43
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,030.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details

ACTA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,
,

Top referenced Smooth Muscle Actin Proteins

  1. Human Smooth Muscle Actin Protein expressed in Escherichia coli (E. coli) - ABIN1098398 : Regalado, Medrek, Tran-Fadulu, Guo, Pannu, Golabbakhsh, Smart, Chen, Shete, Kim, Stern, Braverman, Milewicz: Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms. in American journal of medical genetics. Part A 2011 (PubMed)
    Show all 2 references for ABIN1098398

More Proteins for Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) Interaction Partners

Xenopus laevis Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.

Human Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. ACTA2 mutations are associated with structural disruption and functional impairment of contractile proteins, and predispose to a variety of diffuse vascular diseases including TAAD, CAD, ischemic strokes, and Moyamoya disease. Vascular SMCs are also implicated in vascular remodeling in both physiological and pathological conditions.

  2. Parenchymal alphaSMA expression in hepatic tissue appeared to increase only among hepatitis C subjects with fibrosis 3-4.

  3. Multisystemic smooth muscle dysfunction syndrome secondary to an ACTA2 mutation.

  4. alpha-SMA expression, and MLC phosphorylation, whereas butaprost inhibited TGF-beta2-induced CPCG contraction, actin polymerization, and MLC phosphorylation.

  5. Genetic analysis revealed a missense mutation of the ACTA2 gene, encoding for a smooth muscle isoform of alpha-actin.

  6. NGF (show NGFB Proteins) has a role in modulating trkANGFR/p75NTR (show NGFR Proteins) in alphaSMA-expressing conjunctival fibroblasts from human ocular cicatricial pemphigoid

  7. increased level of alphaSMA, a hallmark of epithelial mesenchymal transition in lens epithelial cells, is associated with increased level of histone H4 acetylation at the promoter region of alphaSMA gene(ACTA2)

  8. Alpha-SMA (show SMN1 Proteins) overexpression induced YAP (show YAP1 Proteins) translocation to the nucleus and reduced the high clonogenicity and adipogenic potential of alpha-SMA (show SMN1 Proteins)-negative MSCs.

  9. The number and distribution of myofibroblasts and the expression levels of ACTA2 in the fetal membrane may be involved in the mechanisms of development, apoptosis and trophoblastmyofibroblast transformation of the fetal membrane.

  10. All the variants analyzed expressed alpha-SMA (show SMN1 Proteins) mildly or moderately, except for the follicular variant that either did not express alpha-SMA (show SMN1 Proteins) or expressed it mildly.

Mouse (Murine) Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta (show TGFB1 Proteins)/SMADS signaling pathway and down-regulating TGF-beta1 (show TGFB1 Proteins), SMAD2 (show SMAD2 Proteins)/3, and alpha-SMA (show SMN1 Proteins) expression.

  2. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 Proteins) during scleral chondrogenesis accompany myopia development.

  3. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.

  4. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A.

  5. The results suggest that the expression level of TGF-b1 and a-SMA in stromal fibroblasts may have prognostic significance in patients with clinical stage I-IIIA NSCLC after curative resection

  6. alphaSMA is a useful marker for further understanding the molecular and cellular characteristics of non-hematopoietic cells in the lymph nodes.

  7. This in vitro expression study revealed the additional profibrotic role of IL-6 (show IL6 Proteins) in fibroblast to myofibroblast transition and in alpha smooth muscle actin (show ACTG2 Proteins) induction.

  8. Data indicate that NRG-1beta up-regulated the gene expressions of Nkx2.5, GATA4, alpha-actin, MLC-2v, and ANF in a time-dependent regulation of ErbB/ERK1/2 pathways.

  9. these studies identify a pathway that culminates in the post-transcriptional regulation of utrophin A through increases in mRNA stability.

  10. sustained Akt1-induced alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin.

Rabbit Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) interaction partners

  1. TnT has a previously unrecognized role in forming the inactive state of regulated actin.

  2. The terminal pointed end subunit is tilted (show OTOP1 Proteins) towards the penultimate subunit, allowing specific and extra loop-to-loop inter-strand contacts between the two end subunits, which is not possible in other parts of the filament.

  3. There was no significant change in the expression of TGF-beta(2 (show TGFB2 Proteins)) and alpha-SMA (show SMN1 Proteins) after laser-assisted intrastromal scanning.

  4. The arrangement of actin subunits in an actin dimer assembled by tandem W domains resembles that of a long-pitch helix of the actin filament.

  5. The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction.

Smooth Muscle Actin (ACTA2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with ACTA2

  • actin, alpha 2, smooth muscle, aorta (acta2)
  • actin, alpha 2, smooth muscle, aorta (ACTA2)
  • actin, alpha 2, smooth muscle, aorta (Acta2)
  • 0610041G09Rik protein
  • a-SMA protein
  • AAT6 protein
  • ACT-4 protein
  • ACTA2 protein
  • actc1 protein
  • ACTSA protein
  • Actvs protein
  • alphaSMA protein
  • asma protein
  • MYMY5 protein
  • sm-actin protein
  • SMactin protein
  • SMalphaA protein
  • wu:fb63d03 protein

Protein level used designations for ACTA2

SM actin , alpha smooth muscle actin , alpha-SM-actin , actin, alpha 2, smooth muscle, aorta , actin alpha cardiac 1 , actin, aortic smooth muscle , vascular smooth muscle alpha-actin , alpha-smooth muscle actin , actin, aortic smooth muscle-like , alpha-cardiac actin , cell growth-inhibiting gene 46 protein , actin, alpha, vascular smooth muscle , alpha-actin-2 , alpha actin 2 , alpha-actin , smooth muscle alpha-actin , alpha actin

GENE ID SPECIES
431847 Xenopus laevis
477587 Canis lupus familiaris
496696 Xenopus (Silurana) tropicalis
733615 Sus scrofa
100074413 Ornithorhynchus anatinus
100173819 Pongo abelii
466148 Pan troglodytes
100062175 Equus caballus
100396597 Callithrix jacchus
100427024 Macaca mulatta
100579983 Nomascus leucogenys
59 Homo sapiens
11475 Mus musculus
322509 Danio rerio
515610 Bos taurus
423787 Gallus gallus
100009271 Oryctolagus cuniculus
81633 Rattus norvegicus
100722917 Cavia porcellus
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