Alkaline Phosphatase, Liver/bone/kidney Proteins (ALPL)

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Additionally we are shipping ALPL Antibodies (224) and ALPL Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ALPL Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Human Cells Mouse Fc Tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$345.35
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Mouse Un-conjugated   10 μg Log in to see 2 to 3 Days
$157.50
Details

ALPL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine) , , ,
,
Rat (Rattus)

Top referenced ALPL Proteins

  1. Human ALPL Protein expressed in Human Cells - ABIN3216384 : Harris: The human alkaline phosphatases: what we know and what we don't know. in Clinica chimica acta; international journal of clinical chemistry 1990 (PubMed)
    Show all 5 references for 3216384

  2. Mouse (Murine) ALPL Protein expressed in Human Cells - ABIN2008674 : Henthorn, Raducha, Fedde, Lafferty, Whyte: Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 5 references for 2008674

More Proteins for Alkaline Phosphatase, Liver/bone/kidney (ALPL) Interaction Partners

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. His ALPL gene mutation came from c.228delG mutation in his mother and c.407G>A compound heterozygous mutation in his father

  2. Both PPARgamma (show PPARG Proteins) gene expression and TNALP activity increased during intracellular lipid accumulation in HepG2 and 3T3-L1 cells. Inhibition of TNALP blocked intracellular lipid accumulation but did not alter expression of the PPARgamma (show PPARG Proteins) gene.

  3. ALPL is a major contributor to the pathogenesis of Prostate cancer progression.

  4. ALPL expression is significantly upregulated in human masticatory mucosa during wound healing

  5. serum ALP (show ALP Proteins) levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.

  6. In conclusion, serum levels of BSP (show KLK6 Proteins), ALP (show ALP Proteins), ICTP, and PSA (show PLAG1 Proteins) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  7. results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.

  8. One-half of adult individuals with unexplained low serum ALP (show ALP Proteins) carried an ALPL mutation. The presence of a mutated allele was associated with tooth loss, slightly lower levels of serum ALP (show ALP Proteins), higher levels of pyridoxal phosphate and phosphoethanolamine, as well as mildly increased serum phosphate.

  9. Dynamic changes of ALP (show ALP Proteins), LDH and PSA (show PLAG1 Proteins) during Abiraterone-therapy are associated with best clinical benefit and OS in bone metastatic castration resistant prostate cancer

  10. Analysis of a series of multiple N-glycan depletion mutants in TNSALP revealed that three N-glycans on N230, N271 and N303 were the minimal requirement for the structure and function of TNSALP and a prerequisite for its stable expression in a cell.

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. These analyses revealed that TNAP deficient mice present an increased proliferation of neural precursors, an altered neuronal morphology, and an augmented neuronal activity. We found that these alterations were associated with a partial downregulation of the purinergic P2X7 receptor (P2X7R (show P2RX7 Proteins)).

  2. Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.

  3. Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.

  4. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  5. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (show SFRP2 Proteins).

  6. p107 (show RBL1 Proteins) is required for the efficient recruitment of an activating SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) chromatin-remodeling complex, an essential event in Alpl induction.

  7. Inhibition of rhBMP-2-induced ALP (show CCL21A Proteins) activity by intracellular delivery of SMURF1 (show SMURF1 Proteins) in murine calvarial preosteoblast cells.

  8. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (show HPR Proteins), including true bony craniosynostosis in the context of severely diminished bone mineralization

  9. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (show TMPRSS5 Proteins) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.

  10. TNAP plays a role in governing the phosphorylation status of phospholamban (show PLN Proteins) in the sarcoplasmic reticulum.

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri (show PLIN1 Proteins)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (show PHB2 Proteins)) and urinary deoxypyridinoline (DPD (show DPYD Proteins)) in dairy cattle are reported.

  2. GPI (show GPI Proteins)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

ALPL Protein Profile

Protein Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney (alpl)
  • alkaline phosphatase, liver/bone/kidney (ALPL)
  • alkaline phosphatase, intestinal, gene 2 (alpi.2)
  • alkaline phosphatase, liver/bone/kidney (Alpl)
  • Akp-2 protein
  • Akp2 protein
  • ALP protein
  • alpl protein
  • AP-TNAP protein
  • APTNAP protein
  • HOPS protein
  • iap protein
  • PHOA protein
  • TNAP protein
  • TNS-AP protein
  • TNSALP protein

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
Selected quality suppliers for ALPL Proteins (ALPL)
Did you look for something else?