Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ALPL Protein (His tag)

ALPL Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7318146
  • Target See all ALPL Proteins
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    Protein Type
    Recombinant
    Origin
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    Human
    Source
    • 8
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This ALPL protein is labelled with His tag.
    Purpose
    Recombinant Human Alkaline Phosphatase/ALPL Protein (His Tag)
    Sequence
    Leu18-Ser502
    Characteristics
    Recombinant Human Alkaline Phosphatase, Tissue-Nonspecific Isozyme is produced by our Mammalian expression system and the target gene encoding Leu18-Ser502 is expressed with a 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product ALPL Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, 2 mM MgSO4, 0.1 mM ZnCl2, pH 7.5.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    Alternative Name
    Alkaline Phosphatase/ALPL (ALPL Products)
    Synonyms
    ALP Protein, iap Protein, alpl Protein, AP-TNAP Protein, APTNAP Protein, HOPS Protein, TNAP Protein, TNSALP Protein, Akp-2 Protein, Akp2 Protein, PHOA Protein, TNS-AP Protein, alkaline phosphatase, liver/bone/kidney L homeolog Protein, alkaline phosphatase, liver/bone/kidney Protein, alkaline phosphatase, intestinal, gene 2 Protein, alkaline phosphatase, liver/bone/kidney pseudogene Protein, alpl.L Protein, ALPL Protein, alpi.2 Protein, LOC100031702 Protein, Alpl Protein
    Background

    Background: Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) is a cell membrane protein which belongs to the alkaline phosphatase family. There are at least four distinct but related alkaline phosphatases in humans: intestinal AP (IAP), placental AP(PLAP), germ cell AP (GCAP) and their genes are clustered on chromosome 2, tissue-nonspecific isozyme (TNAP) which gene is located on chromosome 1. Alkaline phosphatases (APs) are dimeric enzymes, it catalyze the hydrolysis of phosphomonoesters with release of inorganic phosphate. The native ALPL is a glycosylated homodimer attached to the membrane through a GPI-anchor. This isozyme may play a role in skeletal mineralization. Mutations in ALPL gene have been linked directly to different forms of hypophosphatasia,characterized by poorly mineralized cartilage and bones, and this disorder can vary depending on the specific mutation since this determines age of onset and severity of symptoms.

    Synonym: Alkaline Phosphatase, Tissue-Nonspecific Isozyme, AP-TNAP, TNSALP, Alkaline Phosphatase Liver/Bone/Kidney Isozyme, ALPL,HOPS,TNAP

    Molecular Weight
    54.5 kDa
    UniProt
    P05186
You are here: