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APOBEC3B is a member of the cytidine deaminase gene family. Additionally we are shipping APOBEC3B Proteins (4) and many more products for this protein.
Showing 10 out of 51 products:
Cow (Bovine) Polyclonal APOBEC3B Primary Antibody for WB - ABIN2782492
Bogerd, Wiegand, Doehle, Lueders, Cullen: APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells. in Nucleic acids research 2006
exposures to relevant environmental factors might induce APOBEC3A (show APOBEC3A Antibodies) or APOBEC3B expression above genotoxic levels and initiate tumorigenesis in a tissue-specific manner in the right cellular environment where ssDNA is available
APOBEC3B expression increased the incorporation of genomic uracil, invoked DNA damage response (DDR (show DDR1 Antibodies)) biomarkers and caused cell cycle arrest.
The findings demonstrate that covalently-closed circular DNA levels are significantly lower in hepatocellular carcinoma tissues, and that the lower levels are likely to stem in part from up-regulation of APOBEC3B.
Data suggest that heat shock proteins, in particular Hsp90 (show HSP90 Antibodies), stimulate APOBEC3 (show APOBEC3F Antibodies)-mediated DNA deamination activity toward hepatitis B viral DNA, suggesting a potential physiological role in mutagenesis/carcinogenesis and viral innate immunity; Hsp90 (show HSP90 Antibodies) stimulates deamination activity of APOBEC3G (show APOBEC3G Antibodies), APOBEC3B, and APOBEC3C (show APOBEC3C Antibodies) during co-expression in human liver HepG2 cells.
APOBEC3B mRNA levels are significantly higher in breast cancer metastases as compared to the corresponding estrogen receptor (show ESR1 Antibodies)-positive primary tumors.
tumour-infiltrating immune cells may be an important feature of breast cancers arising in women with APOBEC3B germline deletion, and that this may be of particular interest in Asian women where the germline deletion is more common.
the APOBEC3B deletion polymorphism has neither a prognostic nor a predictive value for breast cancer patients.
Single-strand DNA-specific cytidine deaminase APOBEC3B (A3B (show SGCB Antibodies)) damages tRNA genes at 1000-fold higher efficiency than other non-tRNA genomic regions in Saccharomyces cerevisiae. A3B (show SGCB Antibodies)-induced lesions in tRNA genes were predominantly located on non-transcribed strand, while no transcriptional strand bias was observed in protein coding genes. It suggests transcription-dependent mechanism for A3B (show SGCB Antibodies)-induced tRNA gene hypermutation
These data link oncogene (show RAB1A Antibodies), loss of tumour suppressor gene and drug-induced replication stress with APOBEC3B activity, providing new insights into how cytidine deaminase (show CDA Antibodies)-induced mutagenesis might be activated in tumourigenesis and limited therapeutically.
High APOBEC3B mRNA expression was related to the aggressive phenotypes of breast cancer, high frequency of TP53 (show TP53 Antibodies) mutation and poor prognosis, especially in ER-positive tumors.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
, probable DNA dC->dU-editing enzyme APOBEC-3B
, apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B
, DNA dC->dU-editing enzyme APOBEC-3B
, cytidine deaminase
, phorbolin 2
, phorbolin 3
, phorbolin-1-related protein
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
, DNA dC->dU-editing enzyme APOBEC3
, apolipoprotein B editing complex 3
, probable DNA dC->dU-editing enzyme APOBEC3