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ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. Additionally we are shipping Arachidonate 15-Lipoxygenase B Proteins (8) and Arachidonate 15-Lipoxygenase B Kits (6) and many more products for this protein.
Showing 10 out of 68 products:
Human Polyclonal ALOX15B Primary Antibody for EIA, IHC (p) - ABIN950355
Wecksler, Kenyon, Garcia, Deschamps, van der Donk, Holman: Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. in Biochemistry 2009
Show all 2 references for ABIN950355
Cow (Bovine) Polyclonal ALOX15B Primary Antibody for WB - ABIN2777052
Soon, Libe, Benn, Gill, Shaw, Sywak, Groussin, Bertagna, Gicquel, Bertherat, McDonald, Sidhu, Robinson: Loss of heterozygosity of 17p13, with possible involvement of ACADVL and ALOX15B, in the pathogenesis of adrenocortical tumors. in Annals of surgery 2007
Cow (Bovine) Polyclonal ALOX15B Primary Antibody for WB - ABIN2777053
Subbarayan, Xu, Kim, Yang, Hoque, Sabichi, Llansa, Mendoza, Logothetis, Newman, Lippman, Menter: Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. in Neoplasia (New York, N.Y.) 2005
This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2.
The ALOX15B gene may be associated with coronary artery disease.
ALOX15 (show ALOX15 Antibodies) rs11568070 polymorphisms did not discriminate for the disease or its severity.
15-LOX2 expression inhibits Myc (show MYC Antibodies)-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia.
activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin (show F2 Antibodies) generation
Positive feedback-loop of TERT (show TERT Antibodies) and 15-lipoxygenase-2 promotes pulmonary hypertension.
Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain.
ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4 (show IL4 Antibodies), LPS (show IRF6 Antibodies) and hypoxia.
Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups.
Tumor-associated macrophages isolated from RCC (show XRCC1 Antibodies) tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid.
Knockdown of mouse Alox15b in vivo decreased plaque lipid content and markers of inflammation.
15-LOX2 expression in mouse prostate leads to hyperplasia and also induces cell senescence.
8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis.
Purified recombinant 8S-lipoxygenase can function as a potential 15-LOX (show ALOX15 Antibodies) by converting arachidonic acid exclusively to 8S-HPETE and then to (8S,15S)-dihydroperoxy-5Z,9E,11Z,13E-eicosatetraenoic acid (8S,15S-diHPETE).
Expression of 8S-LOX and 15S-LOX-2 (show ALOX5 Antibodies) suppresses CRD-BP/IMP-1 (show IGF2BP1 Antibodies) expression, resulting in inhibition of human prostate carcinoma PC-3 (show PCSK1 Antibodies) cell proliferation.
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
arachidonate 15-lipoxygenase, type B
, arachidonate 15-lipoxygenase, second type
, arachidonate 15-lipoxygenase 2
, arachidonate 15-lipoxygenase B
, arachidonate 15-lipoxygenase type II
, arachidonate omega(6) lipoxygenase
, 15-lipoxygenase 2