C-Type Lectin Domain Family 6, Member A Proteins (CLEC6A)

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Additionally we are shipping C-Type Lectin Domain Family 6, Member A Antibodies (166) and C-Type Lectin Domain Family 6, Member A Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC6A 56620 Q9JKF4
CLEC6A 93978 Q6EIG7
CLEC6A 514979 Q3LUH2
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Top C-Type Lectin Domain Family 6, Member A Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_HEK-293 Cells Mouse Fc Tag   50 μg Log in to see 5 to 8 Days
$362.25
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,379.67
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,392.50
Details

CLEC6A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human ,
, ,
Cow (Bovine)

Top referenced C-Type Lectin Domain Family 6, Member A Proteins

  1. Human CLEC6A Protein expressed in Human Cells - ABIN2002432 : Beutler, Jiang, Georgel, Crozat, Croker, Rutschmann, Du, Hoebe: Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. in Annual review of immunology 2006 (PubMed)

More Proteins for C-Type Lectin Domain Family 6, Member A (CLEC6A) Interaction Partners

Mouse (Murine) C-Type Lectin Domain Family 6, Member A (CLEC6A) interaction partners

  1. a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells

  2. Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.

  3. activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk (show SYK Proteins)-dependent manner.

  4. this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance

  5. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (show TLR4 Proteins) responses through interaction with Dectin-2.

  6. Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 (show HAND1 Proteins) differentiation.

  7. this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis

  8. The results indicate differential roles for Dectin-2 and Mincle (show CLEC4E Proteins) in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice.

  9. Dectin-2 may oppose the Th2 response and IL-4 (show IL4 Proteins)-dependent mucin (show SLC13A2 Proteins) production in the lungs after infection with C. neoformans, and it may not be required for the production of Th1 (show HAND1 Proteins), Th17, and proinflammatory cytokines or for clearance of this fungal pathogen.

  10. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.

Human C-Type Lectin Domain Family 6, Member A (CLEC6A) interaction partners

  1. Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin (show MBL2 Proteins) domain containing 6A)

  2. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 (show TLR4 Proteins) responses through interaction with Dectin-2.

  3. This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis.

  4. human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2

  5. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.

  6. The Dectin-2 possess a single extracellular conserved C-type lectin (show MBL2 Proteins)-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.

  7. Thus, dectin-1 (show CLEC7A Proteins) and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1 (show MALT1 Proteins)-dependent activation of c-Rel (show NFkBP65 Proteins).

  8. human DECTIN-2 has a role in innate immunity

C-Type Lectin Domain Family 6, Member A (CLEC6A) Protein Profile

Protein Summary

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functionnal receptor for alpha-mannans on C. albicans hypheas. Plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. Recognizes also, in a manose dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway.

Gene names and symbols associated with CLEC6A

  • C-type lectin domain family 6, member A (CLEC6A)
  • C-type lectin domain family 4, member n (Clec4n)
  • CLEC4N protein
  • Clec6a protein
  • CLECSF10 protein
  • Nkcl protein

Protein level used designations for CLEC6A

C-type lectin domain family 6, member A , C-type lectin domain family 6 member A , dectin-2 , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10 , C-type lectin superfamily member 10 , DC-associated C-type lectin 2 , dendritic cell-associated C-type lectin 2 , natural killer complex lectin , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 , dectin 2

GENE ID SPECIES
678675 Ovis aries
735479 Pan troglodytes
56620 Mus musculus
93978 Homo sapiens
514979 Bos taurus
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