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CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Additionally we are shipping Caspase 14, Apoptosis-Related Cysteine Peptidase Antibodies (94) and Caspase 14, Apoptosis-Related Cysteine Peptidase Kits (45) and many more products for this protein.
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Mesotrypsin (show PRSS3 Proteins) generated saposins A-D from prosaposin (show PSAP Proteins), and mature caspase-14 contributed to this process by activating mesotrypsinogen (show PRSS3 Proteins) to mesotrypsin (show PRSS3 Proteins). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
caspase-14 overexpression is not the cause of utricle formation
Caspase-14-deficient mice are more prone to the development of parakeratosis.
Mere impairment of filaggrin (show FLG Proteins) degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis.
Caspase-14 is required for filaggrin (show FLG Proteins) degradation to natural moisturizing factors in the skin.
Transcript profiling studies identified caspase (show GATA3 Proteins)-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation (show GATA3 Proteins) and tumorigenesis.
We investigated whether cardiac autonomic control is impaired during sleep in ob/ob mice with morbid obesity caused by congenital leptin (show LEP Proteins) deficiency.
processing of caspase 14 in epidermal differentiation
SH2-B (show SH2B1 Proteins) dramatically enhanced leptin (show LEP Proteins)-stimulated tyrosine phosphorylation of IRS1 (show IRS1 Proteins) and IRS2 (show IRS2 Proteins) in human and mouse cells (this is supposed to be a NEWENTRY for mice--SH2-B (show SH2B1 Proteins)).
Caspase-14, but not caspase-3 (show CASP3 Proteins) activation coincides temporally and spatially with embryonic KC differentiation, suggesting a role for caspase-14 in terminally differentiated KC.
overexpression of S100A7 (show S100A7 Proteins) in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 (show GATA3 Proteins) and caspase-14
caspase-14 contributes to retinal pigment epithelium cell barrier disruption under hyperglycemic conditions.
Caspase-14 was decreased in inflammatory lesions compared to non-lesion in atopic dermatitis. The amount of caspase-14 in the lesions correlated with clinical severity as determined by eczema area and severity index score and the skin barrier functions.
partial loss of caspase 14 is not associated with dedifferentiation in neoplastic lesions of the oral mucosa
genetic polymorphisms in AICDA (show AICDA Proteins) and CASP14 are associated with risk for brain tumor in Korean children.
Suggest caspase-14 is a marker of human skin differentiation during development.
Results suggest that caspase-14 may interact with GCM1 (show GCM1 Proteins) to participate in syncytiotrophoblast differentiation during placental development.
ceramides, an important structural lipid, stimulate caspase-14 expression, coordinating formation of lipid lamellar membranes with the formation of corneocytes
Caspase-14 might play a significant role in the pathogenesis of diabetic retinopathy by accelerating retinal endothelial and epithelial cells death.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
, apoptosis-related cysteine protease
, caspase 14, apoptosis-related cysteine protease