anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Antibodies

human homolog may play a role in regulation of transcription and splicing. Additionally we are shipping Cdc2-Related Kinase, Arginine/serine-Rich Kits (8) and Cdc2-Related Kinase, Arginine/serine-Rich Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRKRS 51755 Q9NYV4
CRKRS 69131 Q14AX6
CRKRS 192350 Q3MJK5
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Top anti-Cdc2-Related Kinase, Arginine/serine-Rich Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB The anti-CRK7 Pab is used in Western blot to detect CRK1 in mouse liver tissue lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: CrkRS Antibody [NLS7350] - Analysis of anti-CDK12 / CRKRS antibody with human breast carcinoma at 6 ug/ml. 0.05 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated WB The anti-CRK7 Pab (ABIN391769) is used in Western blot to detect CRK1 in mouse liver tissue lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated IHC (p) Anti-CDK12 / CRKRS antibody  ABIN1048421 IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Dog Rabbit Un-conjugated IHC (p) Anti-CDK12 / CRKRS antibody  ABIN1048422 IHC staining of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Mouse Un-conjugated ELISA, WB CRKRS monoclonal antibody (M02A), clone 2F6 Western Blot analysis of CRKRS expression in Hela S3 NE . Western Blot detection against Immunogen (36.63 KDa) . 200 μL Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: CrkRS Antibody [NBP1-85451] - Staining of human pancreas shows strong nuclear positivity in exocrine glandular cells and islet cells. Immunocytochemistry/Immunofluorescence: CrkRS Antibody [NBP1-85451] Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to CRKRS on HeLa cell. [antibody concentration 10 ug/ml] Detection limit for recombinant GST tagged CRKRS is 0.1 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$430.00
Details

CRKRS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cdc2-Related Kinase, Arginine/serine-Rich Antibodies

  1. Human Polyclonal CRKRS Primary Antibody for IP, WB - ABIN257745 : Eifler, Shao, Bartholomeeusen, Fujinaga, Jäger, Johnson, Luo, Krogan, Peterlin: Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts. in Molecular and cellular biology 2014 (PubMed)
    Show all 2 references for 257745

  2. Human Polyclonal CRKRS Primary Antibody for EIA, WB - ABIN359679 : Aaronson, Behrens: Ultrastructure of an unusual contractile vacuole in several chrysomonad phytoflagellates. in Journal of cell science 1974 (PubMed)

  3. Dog (Canine) Polyclonal CRKRS Primary Antibody for IHC (p) - ABIN271286 : Capra, Nuciforo, Confalonieri, Quarto, Bianchi, Nebuloni, Boldorini, Pallotti, Viale, Gishizky, Draetta, Di Fiore: Frequent alterations in the expression of serine/threonine kinases in human cancers. in Cancer research 2006 (PubMed)

More Antibodies against Cdc2-Related Kinase, Arginine/serine-Rich Interaction Partners

Fruit Fly (Drosophila melanogaster) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.

  2. CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.

  3. The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.

Human Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications

  2. Structures of CDK12/CycK (show CCNK Antibodies) complexes solved in the presence of AMP (show APRT Antibodies)-PNP (show NP Antibodies).

  3. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK (show CCNK Antibodies)) complex, rendering the kinase inactive.

  4. CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors

  5. CDK12 and CDK13 (show CDK13 Antibodies) losses in HCT116 cells preferentially affect expression of DNA damage response.

  6. CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts

  7. CDK12 has properties that should confirm interest in its use as a biomarker.

  8. many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers

  9. CDK12 interacts with cyclin K (show CCNK Antibodies) and is required to maintain embryonnic stem cell self-renewal.

  10. Cyclin (show PCNA Antibodies) K1 is the primary cyclin (show PCNA Antibodies) partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.

Mouse (Murine) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways

  2. The findings of this study suggest that Cdk12 and Cdk13 (show CDK13 Antibodies) regulate axonal elongation through a common signaling pathway that modulates Cdk5 (show CDK5 Antibodies) expression.

Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Antigen Profile

Protein Summary

human homolog may play a role in regulation of transcription and splicing

Gene names and symbols associated with CRKRS

  • CG7597 gene product from transcript CG7597-RB (Cdk12) antibody
  • Cdc2-related kinase, arginine/serine-rich (LOC100354313) antibody
  • cyclin-dependent kinase 12 (CDK12) antibody
  • cyclin-dependent kinase 12 (Cdk12) antibody
  • 1810022J16Rik antibody
  • AC017581 antibody
  • AI646528 antibody
  • anon-WO0140519.165 antibody
  • cg7597 antibody
  • Crk7 antibody
  • CRKR antibody
  • Crkrs antibody
  • D11Ertd752e antibody
  • dCDK12 antibody
  • Dmel\\CG7597 antibody
  • gi24668141 antibody
  • hCDK12 antibody
  • Pksc antibody

Protein level used designations for CRKRS

CG7597-PA , CG7597-PB , CG7597-PC , Cdk12-PA , Cdk12-PB , Cdk12-PC , Cdc2-related kinase, arginine/serine-rich , CDC2-related protein kinase 7 , cell division cycle 2-related protein kinase 7 , cell division protein kinase 12 , CDC2-related kinase 7 , CDC2-related kinase, arginine/serine-rich , protein kinase for splicing component , cyclin-dependent kinase 12 isoform , cyclin-dependent kinase 12 , Cell division protein kinase 12

GENE ID SPECIES
40385 Drosophila melanogaster
100354313 Oryctolagus cuniculus
51755 Homo sapiens
69131 Mus musculus
192350 Rattus norvegicus
511513 Bos taurus
100467815 Ailuropoda melanoleuca
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