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Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. Additionally we are shipping CENPC1 Kits (12) and and many more products for this protein.
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Human Polyclonal CENPC1 Primary Antibody for EIA, WB - ABIN951465
Brown, Bifulco, Harris, Bridge: Life stress, chronic subclinical symptoms and vulnerability to clinical depression. in Journal of affective disorders 1986
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Human Polyclonal CENPC1 Primary Antibody for EIA, WB - ABIN951464
Gopalakrishnan, Sullivan, Trazzi, Della Valle, Robertson: DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. in Human molecular genetics 2009
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CENP-C specifically binds alpha satellite non-coding RNAs.
CENP-C and CENP-I (show CENPI Antibodies) are key factors connecting kinetochore to CENP-A (show CENPA Antibodies) assembly.
A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3 (show HIST3H3 Antibodies).
HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs.
We used a synthetic system to dissect how CenH3(CENP-A (show CENPA Antibodies)) contributes to the accumulation of CENP-C and CENP-T (show CENPT Antibodies), two key components that are necessary for the formation of functional kinetochores
CENP-C recruits the Ndc80 (show NDC80 Antibodies) complex through its interactions with KNL1 (show CASC5 Antibodies) and the Mis12 (show MIS12 Antibodies) complex at kinetochores during chromosome segregation.
The CENP-A (show CENPA Antibodies)/histone H3.3 (show H3F3A Antibodies) nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A (show CENPA Antibodies) overexpressing tumor cells.
CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores.
CENP-B (show CENPB Antibodies) directly binds both CENP-A's amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly
CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A (show CENPA Antibodies) from centromeres, indicating their collaboration in maintaining centromere identity.
Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
CENP-C works as an important factor for centromeric M18BP1 (show MIS18BP1 Antibodies) recruitment
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
Centromere protein C 1
, CENP-C 1
, centromere autoantigen C
, centromere autoantigen C1
, centromere protein C 1
, interphase centromere complex protein 7
, centromere protein C1
, CENTROMERE PROTEIN C (CENP-C) (CENTROMERE AUTOANTIGEN C)