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anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Antibodies

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Additionally we are shipping Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHFR 231600 Q810L3
CHFR 55743 Q96EP1
CHFR 288734  
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Top anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-CHFR Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB CHFR Antibody (C-term) (ABIN658352) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the CHFR antibody detected the CHFR protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184918 (2.5µg/ml) staining of paraffin embedded human brain (cerebellum). Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 μg of whole cell lysate) A:H1299 7.5% SDS PAGE antibody diluted at 1:1000 WB Image CHFR antibody detects CHFR protein by western blot analysis. Whole cell extracts (30 μg) was separated by 7.5 % SDS-PAGE, and blotted with CHFR antibody , diluted by 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to CHFR on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 2 ug/ml] Western blot analysis of CHFR over-expressed 293 cell line, cotransfected with CHFR Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with CHFR monoclonal antibody (M01), clone 1H3-A12. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated WB Western Blot analysis of CHFR expression in transfected 293T cell line by CHFR monoclonal antibody (M08), clone 2B11. Lane 1: CHFR transfected lysate(72.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of CHFR expression in transfected 293T cell line by CHFR monoclonal antibody (M01), clone 1H3-A12. Lane 1: CHFR transfected lysate(72.1 KDa). Lane 2: Non-transfected lysate. Western blot analysis of CHFR over-expressed 293 cell line, cotransfected with CHFR Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

CHFR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
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Rat (Rattus) , ,
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Top referenced anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Antibodies

  1. Human Monoclonal CHFR Primary Antibody for IHC (p), RNAi - ABIN565913 : Milne, Sitarz, Carvalho, Polak, Ligtenberg, Pauwels, Offerhaus, Weterman: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. in Human pathology 2007 (PubMed)
    Show all 7 references for ABIN565913

  2. Human Polyclonal CHFR Primary Antibody for WB - ABIN658352 : Soutto, Peng, Razvi, Ruemmele, Hartmann, Roessner, Schneider-Stock, El-Rifai: Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. in Cancer 2010 (PubMed)
    Show all 2 references for ABIN658352

  3. Cow (Bovine) Polyclonal CHFR Primary Antibody for IHC, WB - ABIN2774757 : Kang, Kim, Jang, Hong, Hwang, Shin, Park: Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk. in Cancer letters 2008 (PubMed)

  4. Human Polyclonal CHFR Primary Antibody for IHC, ELISA - ABIN184918 : Scolnick, Halazonetis: Chfr defines a mitotic stress checkpoint that delays entry into metaphase. in Nature 2000 (PubMed)

More Antibodies against Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Interaction Partners

Mouse (Murine) Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) interaction partners

  1. CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells.

  2. The interaction between CHFR and PARP-1 (show PARP1 Antibodies) plays an important role in cell cycle regulation and cancer therapeutic strategies.

  3. CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.

  4. RNF8 (show RNF8 Antibodies) and Chfr, function together to activate ATM (show ATM Antibodies) and maintain genomic stability in vivo.

  5. Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

  6. PML bodies control the distribution, dynamics and function of CHFR

  7. Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A (show AURKA Antibodies).

  8. Mice with deficiencies in both Chfr and Mlh1 (show MLH1 Antibodies) (the gene that encodes the DNA mismatch-repair protein Mlh1 (show MLH1 Antibodies)) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes.

Human Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) interaction partners

  1. Data show that hypermethylation of the CHFR promoter, frequent in acute myeloid leukemia (show BCL11A Antibodies), is associated with adverse outcome, and can thus be used for risk stratification.

  2. Small molecule inhibition of CHFR-PARP1 (show PARP1 Antibodies) interaction is a novel potential therapeutic approach to increase the efficacy of taxane-based chemotherapy in cancer.

  3. CHFR unmethylation is associated with oxaliplatin resistance in gastric cancer.

  4. CHFR methylation has a role in methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer

  5. CHFR promoter methylation is associated with colorectal cancer.

  6. CHFR-PAX5 (show PAX5 Antibodies) fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia.

  7. Aberrant methylation of CHFR may be associated with the pathogenesis, progression for B-cell non-Hodgkin lymphoma(B-NHL (show RTEL1 Antibodies)), which might be a novel molecular marker as prognosis and treatment for B-NHL (show RTEL1 Antibodies).

  8. Studies indicate that checkpoint with forkhead and ring finger domains (CHFR) promoter CpG island methylation as prognostic marker.

  9. CHFR ubiquitinates and regulates TOPK (show PBK Antibodies) levels, which is essential for its checkpoint function.

  10. CHFR methylation may have a role in chemosensitivity of paclitaxel in advanced gastric cancer

Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Antigen Profile

Protein Summary

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).

Gene names and symbols associated with CHFR

  • checkpoint with forkhead and ring finger domains (Chfr) antibody
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (CHFR) antibody
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (Chfr) antibody
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) antibody
  • 5730484M20Rik antibody
  • C230082M18 antibody
  • fc43f10 antibody
  • RNF116 antibody
  • RNF196 antibody
  • si:dkey-69h6.7 antibody
  • wu:fc43f10 antibody

Protein level used designations for CHFR

E3 ubiquitin-protein ligase CHFR , checkpoint with forkhead and RING finger domains protein , RING finger protein 196 , Checkpoint with forkhead and RING finger domains protein

GENE ID SPECIES
231600 Mus musculus
55743 Homo sapiens
100154400 Sus scrofa
614816 Bos taurus
288734 Rattus norvegicus
564271 Danio rerio
734287 Xenopus laevis
477434 Canis lupus familiaris
100171543 Pongo abelii
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