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The protein encoded by CHIA degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. Additionally we are shipping Chitinase, Acidic Antibodies (51) and Chitinase, Acidic Kits (9) and many more products for this protein.
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loss of acidic chitinase expression is a promising marker for corpus atrophy
results showed that the expression of AMCase and CHIT-1 were differently modulated in monocyte macrophages at different stage of maturation. The behavior of these two active chitinase suggests that in the immune response their role is complementary.
study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study; also functional effect of the rs3818822 polymorphism on AMCase levels and activity was demonstrated
Report increased CSF chitinase levels in patients with neuromyelitis optica and relapsing remitting multiple sclerosis.
A ten base pair insertion in the second exon in the 5'UTR region of the AMCase gene may modify the gene expression and thus may affect the severity of asthma.
AMCase and eotaxin-3 (show CCL26 Proteins) may be important mediators in the pathogenesis of nasal polyps. The increased AMCase and eotaxin-3 (show CCL26 Proteins) might lead to nasal polyp formation and growth.
Results showed the presence of CHIT1 and AMCase mRNA in gastric mucosa and the correlation with the presence of H. pylori was significant only for CHIT1 but not for AMCase expression.
Environmental exposure to fungi does not modify the effect of CHIA SNPs on severe asthma exacerbations
The levels of expression of AMCase and chitotriosidase mRNAs and proteins were increased in allergic turbinate mucosa compared with normal turbinate mucosa.
Our study found no associations between single nucleotide polymorphisms in the genes CHIT1, CHIA, and CHI3L1 (show CHI3L1 Proteins) and asthma, changes in lung physiology, or allergy-related phenotypes in subjects with mild-to-moderate asthma
Data show that acidic mammalian chitinase (AMCase) functions as a critical initiator of protective type 2 responses to intestinal nematodes, but is largely dispensable for allergic responses in the lung.
AMCase expression was significantly decreased in experimental autoimmune encephalitis mice compared to PBS (show TSPO Proteins)-controls.
Protein A-mouse acidic mammalian chitinase-V5-His expressed in periplasmic space of Escherichia coli possesses chitinase functions comparable to CHO-expressed protein.
AMCase mRNA is a major transcript in mouse stomach acting as a digestive enzyme that breaks down polymeric chitin and as part of the host defense against chitin-containing pathogens in the gastric contents.
Although exposure to allergen stimulates the expression of AMCase and increased chitinolytic activity in murine airways, the overexpression or inhibition of AMCase exerts only a subtle impact on AAD.
findings show that acidic mammalian chitinase is induced via a T helper-2 (Th2)-specific, interleukin-13 (IL-13 (show IL13 Proteins))-mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model
AMCase provides the first positive molecular marker of distal Clara cell secretory protein (show SCGB1A1 Proteins)-expressing cells under these conditions.
lung epithelial cells secrete AMCase via an EGFR-dependent pathway that is activated by ADAM17 and mediates its effects via Ras.
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene.
, acidic mammalian chitinase-like
, acidic mammalian chitinase
, lung-specific protein TSA1902
, chitin-binding protein b04
, acidic chitinase
, eosinophil chemotactic cytokine
, small acid mammalian chitinase