anti-Chromobox Homolog 4 (CBX4) Antibodies

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Additionally we are shipping CBX4 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBX4 12418 O55187
CBX4 8535 O00257
CBX4 501403  
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Top anti-CBX4 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-CBX 4 Antibody Catalog Number: ARP30002 Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X WB Suggested Anti-CBX4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate CBX4 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 11 to 13 Days
$427.35
Details
Human Rabbit Un-conjugated WB The anti-CBX4 C-term Pab (ABIN389087) is used in Western blot to detect CBX4 in Jurkat cell lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-CBX4 N-term Pab (ABIN389086) is used in Western blot to detect CBX4 in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: CBX4 Antibody [NBP1-83225] - Staining of human stomach shows strong cytoplasmic and weak nuclear positivity in glandular cells. Immunocytochemistry/Immunofluorescence: CBX4 Antibody [NBP1-83225] Staining of human cell line A-431 shows positivity in nucleus but not nucleoli, cytoplasm & golgi apparatus. 0.1 mL Log in to see 7 to 9 Days
$439.69
Details
Human Rabbit Un-conjugated WB CBX4 Antibody (N-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CBX4 antibody detected the CBX4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 12 to 15 Days
$411.18
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details

CBX4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Rat (Rattus)


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Top referenced anti-CBX4 Antibodies

  1. Human Polyclonal CBX4 Primary Antibody for WB - ABIN389087 : Kagey, Melhuish, Wotton: The polycomb protein Pc2 is a SUMO E3. in Cell 2003 (PubMed)
    Show all 3 references for 389087

  2. Human Polyclonal CBX4 Primary Antibody for IHC (p), WB - ABIN389086 : Yang, Sharrocks: The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif. in Molecular and cellular biology 2010 (PubMed)
    Show all 3 references for 389086

  3. Human Polyclonal CBX4 Primary Antibody for EIA, IHC (p) - ABIN357750 : Satijn, Olson, van der Vlag, Hamer, Lambrechts, Masselink, Gunster, Sewalt, van Driel, Otte: Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. in Molecular and cellular biology 1997 (PubMed)
    Show all 2 references for 357750

  4. Human Polyclonal CBX4 Primary Antibody for ICC, IF - ABIN4288456 : Ismail, Gagné, Caron, McDonald, Xu, Masson, Poirier, Hendzel: CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. in Nucleic acids research 2012 (PubMed)
    Show all 2 references for 4288456

  5. Human Polyclonal CBX4 Primary Antibody for EIA, WB - ABIN357751 : Vincenz, Kerppola: Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

  6. Human Polyclonal CBX4 Primary Antibody for WB - ABIN2559520 : Han, Wang, Li, Dong, Zhang, Yan: HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells. in Graefe's archive for clinical and experimental ophthalmology 2015 (PubMed)

More Antibodies against CBX4 Interaction Partners

Mouse (Murine) Chromobox Homolog 4 (CBX4) interaction partners

  1. The Cbx4 plays a crucial role in the p63 (show CKAP4 Antibodies)-regulated program of epidermal differentiation, maintaining the epithelial identity and proliferative activity in KCs via repression of the selected nonepidermal lineage and cell cycle inhibitor (show CDKN2A Antibodies) genes.

  2. Data indicate an important role of chromobox homolog 4 protein CBX4 in production of high quality oocytes.

  3. Cbx4 is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.

  4. SUMO interaction motif 2 (SIM2 (show SIM2 Antibodies)) is crucial for many of the documented Pc2 functions, which converge on determining its E3 ligase activity.

  5. Our results suggest that Cbx4 functions as a SUMO E3 ligase for Dnmt3a and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification.

Human Chromobox Homolog 4 (CBX4) interaction partners

  1. provide evidence to show that CBX4 may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 (show HDAC3 Antibodies) to the Runx2 (show RUNX2 Antibodies) promoter to impede Runx2 (show RUNX2 Antibodies) expression

  2. Cbx4 is an independent prognostic factor for HCC (show FAM126A Antibodies) patients, and the patients with high Cbx4 expression should receive postoperative TACE (show ADAM17 Antibodies) treatment to improve their survival

  3. our study demonstrated that miR (show MLXIP Antibodies)-195 acts as a tumor suppressor by directly targeting CBX4 in hepatocellular carcinoma

  4. Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.

  5. The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  6. High cytoplasmic expression of CBX4 is associated with hepatocellular carcinoma.

  7. our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha (show HIF1A Antibodies) protein

  8. ASXL1 (show ASXL1 Antibodies) associates with the PRC2 and loss of ASXL1 (show ASXL1 Antibodies) in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.

  9. High Polycomb (show CBX2 Antibodies) repressive complex protein is associated with mesothelioma.

  10. Pc2 (show KRT6B Antibodies), methylation controls the protein's interaction with two distinct ncRNAs, TUG1 and NEAT2, which results in the exclusive subnuclear localization of methylated and unmethylated Pc2 (show KRT6B Antibodies) in Polycomb (show CBX2 Antibodies) bodies and interchromatin granules, respectively.

CBX4 Antigen Profile

Protein Summary

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene names and symbols associated with CBX4

  • chromobox homolog 4 (CBX4) antibody
  • chromobox 4 (Cbx4) antibody
  • chromobox homolog 4 (cbx4) antibody
  • chromobox homolog 4 (Cbx4) antibody
  • chromobox homolog 4 (Pc class homolog, Drosophila) (cbx4) antibody
  • cbx4-a antibody
  • im:6911625 antibody
  • MPc2 antibody
  • NBP16 antibody
  • PC2 antibody
  • XPolycomb antibody
  • zgc:158588 antibody

Protein level used designations for CBX4

chromobox homolog 4 , E3 SUMO-protein ligase CBX4 , chromobox protein homolog 4 , polycomb 2 homolog , NS5ATP1-binding protein 16 , Pc class 2 homolog , chromobox homolog 4 (Pc class homolog, Drosophila) , chromobox homolog 4 (Pc class homolog) , chromobox homolog 4 (Polycomb) , chromobox protein (CHCB3) , chromobox-like protein 4 , polycomb 2

GENE ID SPECIES
744720 Pan troglodytes
12418 Mus musculus
8535 Homo sapiens
394294 Xenopus laevis
395354 Gallus gallus
608556 Canis lupus familiaris
767865 Bos taurus
501403 Rattus norvegicus
573110 Danio rerio
Selected quality suppliers for anti-CBX4 (CBX4) Antibodies
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