anti-Chromosome 12 Open Reading Frame 5 (C12orf5) Antibodies

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Additionally we are shipping Chromosome 12 Open Reading Frame 5 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
C12orf5 57103 Q9NQ88
C12orf5 319801 Q8BZA9
C12orf5    
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Top anti-Chromosome 12 Open Reading Frame 5 Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western Blot: TIGAR/C12orf5 Antibody  - Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE gel, diluted at 1:2000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 12 to 14 Days
$541.80
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 12 to 14 Days
$541.80
Details
Human Mouse Un-conjugated WB Western Blot analysis of C12orf5 expression in transfected 293T cell line by C12orf5 MaxPab polyclonal antibody.<br><br>Lane 1: C12orf5 transfected lysate(29.7 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 12 to 14 Days
$541.80
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 12 to 14 Days
$541.80
Details
Human Mouse Un-conjugated IP, WB   0.05 mg Log in to see 18 to 20 Days
$381.94
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB   0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB   0.025 mL Log in to see 7 to 9 Days
$148.31
Details
Human Rabbit Un-conjugated IHC (p), WB   0.025 mg Log in to see 7 to 9 Days
$148.31
Details

C12orf5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against Chromosome 12 Open Reading Frame 5 Interaction Partners

Human Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. High TIGAR expression was an independent predictor of poor survival and high incidence of relapse in adult patients with CN-AML (show RUNX1 Antibodies). TIGAR also showed high expression in multiple human leukemia cell lines and knockdown of TIGAR activated glycolysis through PFKFB3 (show PFKFB3 Antibodies) upregulation in human leukemia cells.

  2. the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation.

  3. TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine (show GFPT1 Antibodies) catabolism.

  4. we investigate the crosstalk between PFKFB3 (show PFKFB3 Antibodies) and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 (show PFKFB3 Antibodies) knockdown

  5. The study showed that miR (show MLXIP Antibodies)-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 (show PCSK1 Antibodies) cell line by decreasing NADPH (show NQO1 Antibodies) levels by throughly directly binding to 3'-UTR (show UTS2R Antibodies) of TIGAR mRNA and repressing TIGAR expression.

  6. This study demonstrated that a high p53 (show TP53 Antibodies) expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression.

  7. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  8. TIGAR knockdown reduced tumor growth rate.

  9. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (show TP53 Antibodies) mutation.

  10. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  2. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Antibodies) or TAp73 (show TP73 Antibodies).

  3. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  4. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (show TXN Antibodies) nuclear translocation.

  5. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  6. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  7. p53 (show TP53 Antibodies)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  8. p53 (show TP53 Antibodies) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (show TP53 Antibodies) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) Antigen Profile

Protein Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene names and symbols associated with C12orf5

  • TP53 induced glycolysis regulatory phosphatase (TIGAR) antibody
  • TP53 induced glycolysis regulatory phosphatase (tigar) antibody
  • TP53 induced glycolysis regulatory phosphatase S homeolog (tigar.S) antibody
  • Trp53 induced glycolysis repulatory phosphatase (Tigar) antibody
  • AA793651 antibody
  • AI595337 antibody
  • C12orf5 antibody
  • C79710 antibody
  • C85509 antibody
  • FR2BP antibody
  • Tigar antibody

Protein level used designations for C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPECIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
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