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The protein encoded by CSF3R is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. Additionally we are shipping CSF3R Antibodies (136) and CSF3R Kits (25) and many more products for this protein.
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Human CSF3R Protein expressed in Human Cells - ABIN2002378
Germeshausen, Ballmaier, Welte: Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey. in Blood 2006
Show all 5 references for ABIN2002378
The Colony-Stimulating Factor (show CSF2 Proteins) 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK (show JAK3 Proteins) Inhibition, and Mimics T618I
CSF3R mutations, mechanisms of mutations, and their contributions to the myeloid malignancies (Review)
In conclusion, rhCSF3 can promote melanocyte proliferation through CSF3R without affecting tyrosinase (show TYR Proteins) activity
CSF3R mutations are associated with congenital neutropenia.
The leukemogenic potential of G-CSFRIV is associated with the Stat5 (show STAT5A Proteins)-dependent dysregulation of miR (show MLXIP Proteins)-155 and the target genes of this miRNA.
No CSF3R mutations were found in cases of MDS (show PAFAH1B1 Proteins), JMML or ET. The only mutation found in the CALR (show CALR Proteins) gene was a frameshift (p.L367 fs) in one ET patient.
The SETBP1 (show SETBP1 Proteins) and ASXL1 (show ASXL1 Proteins) mutations have pathogenetic roles in CSF3R-mutated chronic neutrophilic leukemia.
CSF3R polymorphisms are associated with chronic neutrophilic leukemia.
CSF3R T618I mutation as a disease-specific marker of atypical CML post allo-SCT in two patients.
the incorporation of CSF3R mutation testing can be a useful point-of-care diagnostic to evaluate the presence of a clonal myeloid disorder, as well as providing the potential for genetically informed therapy.
Thr (show TRH Proteins)-615 and Thr (show TRH Proteins)-618 sites of membrane-proximal mutations are part of an O-linked glycosylation cluster. Mutation at these sites prevents O-glycosylation of CSF3R and increases receptor dimerization.
Fbw7 (show FBXW7 Proteins) together with GSK3beta negatively regulates G-CSFR expression and its downstream signaling.
G-CSFR signaling interacts with retinoic acid receptors in the regulation of myeloid differentiation
Expression of truncated G-CSFR significantly shortens the latency of AML (show RUNX1 Proteins) in a G-CSF (show CSF3 Proteins)-dependent fashion and it is associated with a distinct AML (show RUNX1 Proteins) presentation characterized by higher blast counts and more severe myelosuppression.
G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance, ultimately leading to hematopoietic stem and progenitor cell mobilization.
Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF (show CSF3 Proteins)-induced expansion of myeloid progenitor cells.
murine granulocyte colony-stimulating factor receptor binds to a low molecular weight ligand
Mice with truncated G-CSF (show CSF3 Proteins) receptors have neutropenia, susceptibility to infection, and bone marrow maturation arrest similar to severe congenital neutropenic humans, suggesting a role of receptor truncation mutations in SCN (show SRI Proteins) pathology.
COOH-terminal truncation mutants of G-CSF-R, found in severe congenital neutropenia, lack internalization motifs and are completely defective in both spontaneous and ligand-induced internalization.
activation of both the Flt-3 (show FLT3 Proteins) and G-CSF (show CSF3 Proteins) receptors provides a high degree of radioprotection to the hematopoietic progenitor cell and stem cell compartment.
GCSF (show CSF3 Proteins)/GCSFR is a conserved signaling system for facilitating the production of multiple myeloid cell lineages, as well as for early myeloid cell migration.
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
granulocyte colony-stimulating factor receptor
, colony stimulating factor 3 receptor (granulocyte)
, granulocyte colony-stimulating factor receptor-like
, CD114 antigen
, G-CSF receptor
, granulocyte stimulating factor receptor