anti-Cytochrome B-245, beta Polypeptide (CYBB) Antibodies

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Additionally we are shipping CYBB Kits (9) and CYBB Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYBB 1536 P04839
CYBB 13058 Q61093
CYBB 66021  
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Top anti-CYBB Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CYBB Antibody Titration: 1.0ug/mlELISA Titer: 1:62500Positive Control: THP-1 cell lysate IHC Information: Lung, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreas labeled with Anti NOX2/gp91phox Polyclonal Antibody, Unconjugated (ABIN750688) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-NOX2/gp91phox Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Mouse Un-conjugated WB 0.1 mL Log in to see 7 to 8 Days
$455.84
Details
Human Mouse Un-conjugated ICC, IF, IHC (p), WB 0.1 mL Log in to see 7 to 8 Days
$455.84
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of gp91[phox] on mouse macrophage lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of gp91[phox] antibody. Immunofluorescent staining of mouse macrophage cells with gp91[phox] antibody. 50 μg Log in to see 6 to 8 Days
$154.07
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-NOX2/gp91phox antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: JURKAT Cell Lysate Lane 3: MCF-7 Cell Lysate Lane 4: SMMC Cell Lysate Anti-NOX2/gp91phox antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: CYBB/NOX2 Antibody [NBP2-13037] - Extracts from HT29cells. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Mouse Un-conjugated IHC (p), WB 0.25 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western Blot (WB) analysis of K562 cells using gp91-phox Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated ELISA, WB Western Blot (WB) analysis of specific cells using gp91-phox Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details

CYBB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CYBB Antibodies

  1. Human Polyclonal CYBB Primary Antibody for IF (cc), IF (p) - ABIN750688 : Dalaklioglu, Tasatargil, Kale, Tanriover, Dilmac, Erin: Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-? and NADPH oxidase. in Vascular pharmacology 2013 (PubMed)
    Show all 5 references for 750688

  2. Human Polyclonal CYBB Primary Antibody for IHC (p), WB - ABIN3044252 : Liao, Liu, Guo, Zhang, Zhang: Oxidative burst of circulating neutrophils following traumatic brain injury in human. in PLoS ONE 2013 (PubMed)
    Show all 4 references for 3044252

  3. Mouse (Murine) Monoclonal CYBB Primary Antibody for IF, WB - ABIN968523 : Jacobsen, Skalnik: YY1 binds five cis-elements and trans-activates the myeloid cell-restricted gp91(phox) promoter. in The Journal of biological chemistry 1999 (PubMed)
    Show all 4 references for 968523

  4. Human Polyclonal CYBB Primary Antibody for IHC, IHC (p) - ABIN4301440 : Rajtik, Carnicka, Szobi, Giricz, O-Uchi, Hassova, Svec, Ferdinandy, Ravingerova, Adameova: Oxidative activation of CaMKIIδ in acute myocardial ischemia/reperfusion injury: A role of angiotensin AT1 receptor-NOX2 signaling axis. in European journal of pharmacology 2016 (PubMed)
    Show all 3 references for 4301440

  5. Human Monoclonal CYBB Primary Antibody for ICC, IF - ABIN1042596 : Burritt, Quinn, Jutila, Bond, Jesaitis: Topological mapping of neutrophil cytochrome b epitopes with phage-display libraries. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for 1042596

  6. Human Monoclonal CYBB Primary Antibody for WB - ABIN1042597 : Baniulis, Burritt, Taylor, Dinauer, Heyworth, Parkos, Magnusson, Jesaitis: Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox. in European journal of haematology 2005 (PubMed)

  7. Human Polyclonal CYBB Primary Antibody for WB - ABIN2781794 : Fink, Duval, Martel, Soucy-Faulkner, Grandvaux: Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

More Antibodies against CYBB Interaction Partners

Zebrafish Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. The nox1 (show NOX1 Antibodies), nox2/cybb expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization

Rabbit Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that NADPH oxidase (show NOX1 Antibodies) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.

Human Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. NOX2, NOX4 (show NOX4 Antibodies), and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 (show ANGPT1 Antibodies) signaling and angiogenic responses in endothelial cells.

  2. PFK-2 (show PFKFB3 Antibodies) seems to be a strategic element that links NADPH oxidase (show NOX1 Antibodies) activation and glycolysis modulation, and, as such, is proposed as a potential therapeutic target in inflammatory diseases.

  3. data support NOX2 as a critical component of the suppressive machinery of CD8 (show CD8A Antibodies) Tregs and suggest that repairing NOX2 deficiency in these cells may protect older individuals from tissue-destructive inflammatory disease, such as large-vessel vasculitis.

  4. CD8 (show CD8A Antibodies)+ T cells in close contact with target T cells release NADPH oxidase 2-containing microvesicles that inhibit TCR activation by elevating ROS (show ROS1 Antibodies) and thereby reducing phosphorylation of the TCR-associated kinase ZAP70 (show ZAP70 Antibodies).

  5. Thioredoxin (show TXN Antibodies) attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2-NOX4 (show NOX4 Antibodies) activity.

  6. Nox4 (show NOX4 Antibodies)-derived H2O2 in part activates Nox2 to increase mitochondrial ROS (show ROS1 Antibodies) via pSer36-p66Shc (show SHC1 Antibodies), thereby enhancing VEGFR2 (show KDR Antibodies) signaling and angiogenesis in endothelial cells.

  7. Cytochrome b558 (show CYBA Antibodies) also traffics from a lysosomal pool to phagosomes and this is required to replenish oxidatively damaged NOX2.

  8. Nox4 (show NOX4 Antibodies) should contribute to the pathological processes insubarachnoid hemorrhage(SAH (show ACSM3 Antibodies))-induced early brain injury (EBI (show TBL1X Antibodies)), and there was not an overlay effect of Nox2 inhibition and Nox4 (show NOX4 Antibodies) inhibition on preventing SAH (show ACSM3 Antibodies)-induced EBI (show TBL1X Antibodies).

  9. NADPH oxidase (show NOX1 Antibodies) promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease

  10. TLR4 (show TLR4 Antibodies)- and TLR2 (show TLR2 Antibodies)-induced IRAK (show IRAK1 Antibodies)-ERK (show EPHB2 Antibodies) pathway cross-talks with p67phox (show NCF2 Antibodies)-Nox-2 for reactive oxygen species generation, thus regulating IL-1beta (show IL1B Antibodies) transcription and processing in monocytic cells.

Cow (Bovine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that the efficiency of NADPH oxidase (show NOX1 Antibodies) enzymatic activity is higher at endoplasmic reticulum (ER).

  2. A p47(phox) and Src kinase (show CSK Antibodies) activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (show PKC Antibodies)

Mouse (Murine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Redox-dependent regulation of EGFR (show EGFR Antibodies) activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 (show DUOX1 Antibodies) or NOX2.

  2. NOX2 signaling in macrophages participates in the pathogenesis of obesity, and reinforce a key role for macrophage inflammation in diet-induced metabolic and neurologic decline

  3. Studies in knockout and knock-in mice showed that the phospholipase A2 (show YWHAZ Antibodies) activity of peroxiredoxin 6 (show PRDX6 Antibodies) activates NOX2 in cultured pulmonary endothelial cells and alveolar macrophages, clarifying the metabolism of lysophosphatidyl chold to lysophosphatidic acid.

  4. NOX2 knockout mice had significantly lower blood pressure than littermate controls, with both endothelial cells and myeloid cells having a deficiency in NOX2.

  5. Data show that pan (show SUPT6H Antibodies)-NOX-inhibitor APX (show SHROOM1 Antibodies)-115 treatment decreased NADPH oxidase (show NOX1 Antibodies) (Nox) Nox1 (show NOX1 Antibodies), Nox2, and Nox4 (show NOX4 Antibodies) protein expression in the kidney.

  6. NOX2 regulates proinflammatory TLR signaling and alveolar remodeling induced by a single dose of lipopolysaccharides.

  7. a deficiency in MyD88 (show MYD88 Antibodies) or CybB is associated with impaired bacterial clearance and increased granuloma formation in the lung.

  8. NOX2 isoform was first discovered as a component of the oxidative burst in neutrophils and is a complex consisting of several cytosolic subunits (p47phox (show NCF1 Antibodies), p67phox (show NCF2 Antibodies), p40phox (show NCF4 Antibodies), and Rac1 or Rac2 (show RAC2 Antibodies)) and a membrane-associated cytochrome b558 (show CYBA Antibodies) reductase made up of gp91phox and p22phox (show CYBA Antibodies) subunits.

  9. Macrophage-produced HMGB1 (show HMGB1 Antibodies) leads to aortic inflammation and acts as a trigger for CD4 (show CD4 Antibodies)(+) T-cell-produced IL-17 (show IL17A Antibodies) during abdominal aortic aneurysm formation. HMGB1 (show HMGB1 Antibodies) release is dependent on Nox2 activation, which can be inhibited by MSCs leading to attenuation of proinflammatory cytokines and protection against AAA (show AAAS Antibodies) formation.

  10. NOX2 is important for ROS (show ROS1 Antibodies) generation induced by both the GPCR (show GPBAR1 Antibodies) and the GPVI (show GP6 Antibodies)/ITAM signaling pathways in blood platelets.

Pig (Porcine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Antibodies) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation

  2. Reactive oxygen species generated by NADPH oxidase (show NOX1 Antibodies) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

  3. Upregulation of PPAR-gamma (show PPARG Antibodies) and NADPH (show NQO1 Antibodies) oxidases are involved in restenosis.

CYBB Antigen Profile

Protein Summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene names and symbols associated with CYBB

  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (cybb) antibody
  • cytochrome b-245, beta polypeptide (cybb) antibody
  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (CYBB) antibody
  • cytochrome b-245, beta polypeptide (CYBB) antibody
  • cytochrome b-245 beta polypeptide (CYBB) antibody
  • cytochrome b-245, beta polypeptide (Cybb) antibody
  • NADPH oxidase heavy chain subunit (GP91-PHOX) antibody
  • AMCBX2 antibody
  • C88302 antibody
  • Cgd antibody
  • CGD91-phox antibody
  • CYBB antibody
  • Cyd antibody
  • GP91-1 antibody
  • Gp91-phox antibody
  • GP91PHOX antibody
  • NOX1 antibody
  • Nox2 antibody
  • p91-PHOX antibody
  • zgc:64144 antibody

Protein level used designations for CYBB

cytochrome b-245, beta polypeptide , gp91 , NADPH oxidase 2 , cytochrome b-245, beta polypeptide (chronic granulomatous disease) , Cytochrome b-245 heavy chain , NADPH oxidase heavy chain subunit , NADPH oxidase 1 , NADPH oxidase flavocytochrome b subunit , cytochrome b-245 heavy chain , gp91-phox , CGD91-phox , cytochrome b(558) subunit beta , cytochrome b558 subunit beta , heme-binding membrane glycoprotein gp91phox , neutrophil cytochrome b 91 kDa polypeptide , p22 phagocyte B-cytochrome , superoxide-generating NADPH oxidase heavy chain subunit , gp91-1 , endothelial type gp91-phox , predicted NADPH oxidase-2

GENE ID SPECIES
393386 Danio rerio
595081 Xenopus (Silurana) tropicalis
696542 Macaca mulatta
444353 Xenopus laevis
100036757 Ovis aries
100270807 Salmo salar
100008801 Oryctolagus cuniculus
1536 Homo sapiens
418581 Gallus gallus
281112 Bos taurus
13058 Mus musculus
66021 Rattus norvegicus
491825 Canis lupus familiaris
397108 Sus scrofa
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