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anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Antibodies

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. Additionally we are shipping CTLA4 Proteins (77) and CTLA4 Kits (44) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CTLA4 12477 P09793
CTLA4 1493 P16410
CTLA4 63835  
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Top anti-CTLA4 Antibodies at antibodies-online.com

Showing 10 out of 440 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Rat Mouse PE FACS Staining of rat CD152 transfected cell line following permeabilisation. 100 Tests Log in to see 6 to 8 Days
$511.50
Details
Human Rabbit Un-conjugated IHC (p), WB IDDM12 Antibody (N-term)  western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the IDDM12 antibody detected the IDDM12 protein (arrow). IDDM12 Antibody (N-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate  carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the IDDM12 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse FITC FACS 0.1 mg Log in to see 6 to 8 Days
$368.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin fixed and paraffin embedded human prostate carcinoma reacted with CD152 / CTLA4 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of CD152 / CTLA4 Antibody (N-term) in WiDr cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Rat Mouse FITC FACS   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Mouse lung lysate probed with Anti CTLA4 Polyclonal Antibody, Unconjugated (ABIN1714514) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 34kD. Observed band size: 34kD 100 μL Log in to see 14 to 21 Days
$307.45
Details
Rat Mouse Un-conjugated EIA, FACS, IHC (fro), WB   0.25 mg Log in to see 6 to 8 Days
$313.50
Details
Mouse Rat Fluorescein FACS 100 Tests Log in to see 6 to 7 Days
$315.00
Details
Mouse Rat Un-conjugated FACS, Neut, WB CTLA-4 Inhibition of B7-1/CD80-induced IL-2 Secretion and Neutralization by Mouse CTLA-4 Antibody. Recombinant Mouse CTLA-4 Fc Chimera. 100 μg Log in to see 6 to 7 Days
$367.50
Details
Human Mouse Biotin FACS   1 mL Log in to see 6 to 8 Days
$401.50
Details

CTLA4 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-CTLA4 Antibodies

  1. Human Polyclonal CTLA4 Primary Antibody for EIA, IHC (p) - ABIN951196 : Liu, Liang, Gao, Pan, Chen, Wang, Xue, Zhang, Zhang: CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. in Human immunology 2010 (PubMed)
    Show all 5 references for ABIN951196

  2. Rat (Rattus) Monoclonal CTLA4 Primary Antibody for EIA, FACS - ABIN119631 : Lin, Hünig: Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. in European journal of immunology 2003 (PubMed)
    Show all 2 references for ABIN119631

  3. Human Monoclonal CTLA4 Primary Antibody for FACS - ABIN1105901 : Saito, Sakurai, Ohata, Kohsaka, Hashimoto, Okumura, Abe, Azuma: Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 2 references for ABIN1105901

  4. Rat (Rattus) Monoclonal CTLA4 Primary Antibody for FACS - ABIN119633 : Elflein, Rodriguez-Palmero, Kerkau, Hünig: Rapid recovery from T lymphopenia by CD28 superagonist therapy. in Blood 2003 (PubMed)
    Show all 2 references for ABIN119633

  5. Human Monoclonal CTLA4 Primary Antibody for FACS - ABIN951193 : Vijayakrishnan, Slavik, Illés, Greenwald, Rainbow, Greve, Peterson, Hafler, Freeman, Sharpe, Wicker, Kuchroo: An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. in Immunity 2004 (PubMed)
    Show all 2 references for ABIN951193

  6. Mouse (Murine) Monoclonal CTLA4 Primary Antibody for FACS, Neut - ABIN4900291 : Kipnis, Cardon, Avidan, Lewitus, Mordechay, Rolls, Shani, Schwartz: Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 (PubMed)

  7. Mouse (Murine) Monoclonal CTLA4 Primary Antibody for FACS - ABIN4897502 : Al-Sadeq, Hamad, Abu-Elteen: Patterns of Expression of Vaginal T-Cell Activation Markers during Estrogen-Maintained Vaginal Candidiasis. in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2010 (PubMed)

  8. Human Polyclonal CTLA4 Primary Antibody for WB - ABIN1714514 : Tamaka, Seike, Hagiwara, Sato, Ohtsu: Histamine suppresses regulatory T cells mediated by TGF-? in murine chronic allergic contact dermatitis. in Experimental dermatology 2015 (PubMed)

More Antibodies against CTLA4 Interaction Partners

Mouse (Murine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Data suggest enhanced clinical benefit from combining CTLA-4 antigen blockade with poxvirus-based active immunotherapy.

  2. up-regulated expression correlates with the tolerogenic effect of syngeneic hematopoietic stem cell transplantation

  3. Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner

  4. CTLA-4 has a regulatory T cell-intrinsic role in limiting peripheral regulatory T cell expansion and activation, and in their capacity to control conventional T cells.

  5. The Ctla4 SNP (e2_77A/G) does not alter diabetes susceptibility, but does control mRNA alternative splicing.

  6. Sorafenib suppressed the expression of immunosuppressive factors in MDSCs. These data indicate that combination therapy of sorafenib and anti-CTLA-4 Ab may be effective in advanced kidney cancer patients.

  7. The co-stimulatory molecule CTLA-4 mediates in vitro differentiation of iTreg cells.

  8. The bullseye immunological synapse formation is mediated by CTLA4, and may negatively control T-cell activation as a suppressive synapse.

  9. this study reports that regulatory T (Treg) cells orchestrate memory T cell quiescence by suppressing effector and proliferation programs through inhibitory receptor, cytotoxic- T-lymphocyte-associated protein-4 (CTLA-4).

  10. Short-term blockade with anti-CTLA-4 antibody in wild-type mice is sufficient to elicit follicular helper T cell generation and germinal center development. The latter occurs in a CD28 (show CD28 Antibodies)-dependent manner.

Human Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Immune checkpoint proteins are co-inhibitory factors that can diminish the antigen-specific immune responses by attenuating the regulatory role of cytotoxic T-lymphocyte-associated protein 4, programmed cell death-1 (show PDCD1 Antibodies), lymphocyte-activation gene 3 (show LAG3 Antibodies), and T-cell immunoglobulin mucin-3 (show HAVCR2 Antibodies).

  2. genetic polymorphisms in the immune genes IL-3 (show IL-3 Antibodies) rs181781 and CTLA4 rs4553808 may influence the TAC (show IL2RA Antibodies) dose-adjusted concentrations

  3. The results showed that CTLA4 was associated with both Graves disease and Hashimoto disease, and played an equivalent role in both adult and pediatric disease in Han Chinese population.

  4. this paper show that polymorphisms of CTLA-4 gene may influence the risk of developing recurrent pregnancy loss among Iranian women

  5. this study shows that the CTLA4 is not main factor contributing to determining common genetic basis among Graves disease and alopecia areata

  6. this study shows that CTLA4 gene polymorphism is associated wit the risk of allergic rhinitis in China

  7. This study showed that CTLA-4 affects the expression of the key regulators of G1 phase progression in chronic lymphocytic leukaemia cells as well as in normal B lymphocytes.

  8. There is an association between systemic inflammatory markers, oxidative stress and the cytotoxic T lymphocyte antigen-4 G-1661A GG+AG genotypes, malondialdehyde and neopterin which are the most conventional risk factors for coronary heart disease.

  9. genetic association studies in an Egyptian population: Data suggest an SNP in the promoter region of CTLA4 (rs5742909, -318C/T) is associated with rheumatoid arthritis in the population studied; severity of the disease does not appear to be associated with this SNP.

  10. It failed to show any association between CTLA-4 -318C/T polymorphism and the risk of malignant bone tumors.

Pig (Porcine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (show CD80 Antibodies)-positive cells.

Cow (Bovine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (show ZAP70 Antibodies) were decreased in CD4 (show CD4 Antibodies)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

  2. These results suggested that the expression level of CTLA-4 in CD4 (show CD4 Antibodies)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.

  3. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (show FOXP3 Antibodies) and CTLA4.

CTLA4 Antigen Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Gene names and symbols associated with CTLA4

  • cytotoxic T-lymphocyte-associated protein 4 precursor (CTLA-4) antibody
  • cytotoxic T-lymphocyte-associated protein 4 (CTLA4) antibody
  • cytotoxic T-lymphocyte-associated protein 4 (LOC100222727) antibody
  • cytotoxic T-lymphocyte-associated protein 4 (Ctla4) antibody
  • CD antibody
  • Cd152 antibody
  • CELIAC3 antibody
  • Ctla-4 antibody
  • CTLA4 antibody
  • GRD4 antibody
  • GSE antibody
  • IDDM12 antibody
  • Ly-56 antibody
  • sCTLA4 antibody

Protein level used designations for CTLA4

cytotoxic T-lymphocyte-associated protein 4 precursor , CD152 protein , cytotoxic T-lymphocyte protein 4 , cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM , cytotoxic T-lymphocyte-associated protein 4 , costimulatory molecule B7 receptor , cytotoxic T lymphocyte-associated antigen 4 , CD152 antigen , cytotoxic T-lymphocyte-associated antigen 4 , CD152 isoform , celiac disease 3 , cytotoxic T lymphocyte associated antigen 4 short spliced form , cytotoxic T-lymphocyte antigen 4 , cytotoxic T-lymphocyte-associated serine esterase-4 , ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 , soluble form , transmembrane form , CTLA-4 , cytotoxic T lymphocyte-associated protein 4 , costimulatory molecule B7 receptor CD152

GENE ID SPECIES
443040 Ovis aries
705673 Macaca mulatta
100222727 Taeniopygia guttata
424106 Gallus gallus
470619 Pan troglodytes
493743 Felis catus
100126716 Papio anubis
12477 Mus musculus
1493 Homo sapiens
63835 Rattus norvegicus
100009412 Oryctolagus cuniculus
397286 Sus scrofa
403696 Canis lupus familiaris
281732 Bos taurus
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