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Cytotoxic and Regulatory T Cell Molecule Proteins (CRTAM)

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009].. Additionally we are shipping CRTAM Antibodies (57) and CRTAM Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRTAM 56253 O95727
CRTAM 54698  
Rat CRTAM CRTAM 300649  
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Top CRTAM Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$280.50
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_HEK-293 Cells Cynomolgus Fc Tag   100 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$460.85
Details

CRTAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Cytotoxic and Regulatory T Cell Molecule (CRTAM) Interaction Partners

Human Cytotoxic and Regulatory T Cell Molecule (CRTAM) interaction partners

  1. These results reveal that CRTAM is critical to instruct the differentiation of CD4 (show CD4 Proteins)(+)CTL through the induction of Eomes (show EOMES Proteins) and CTL-related gene.

  2. CRTAM is negatively regulated by ZEB1 in T cells.

  3. Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 (show RASGRF2 Proteins) genes.

  4. The cell adhesion molecule (show MCAM Proteins) Necl-2 (show CADM1 Proteins) competitively binds the immune receptor CRTAM.

  5. The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 (show CADM1 Proteins) on tumor cells.

  6. Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level.

  7. Results show that CRTAM is a molecule involved in epithelial cell adhesion.

  8. Necl2 (show CADM1 Proteins)/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system

  9. NK cells and T8 cells recognize Necl-2 (show CADM1 Proteins) through CRTAM, expressed only on activated cells. CRTAM-Necl-2 (show CADM1 Proteins) interactions promote cytotoxicity of NK cells and IFN-gamma (show IFNG Proteins) secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 (show CADM1 Proteins)

  10. CRTAM expression is driven by the JNK (show MAPK8 Proteins)-AP-1 (show FOSB Proteins) signaling pathway.

Mouse (Murine) Cytotoxic and Regulatory T Cell Molecule (CRTAM) interaction partners

  1. These results reveal that CRTAM is critical to instruct the differentiation of CD4 (show CD4 Proteins)(+)CTL through the induction of Eomes (show EOMES Proteins) and CTL-related gene.

  2. During pathogenic infection, Crtam-Cadm1 (show CADM1 Proteins) interactions regulate the dynamic equilibrium between newly formed CD4 (show CD4 Proteins)(+) T cells and their retention in the gut (show GUSB Proteins).

  3. TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1 (show CADM1 Proteins)) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells.

  4. In reciprocal crosses involving alcohol-preferring and alcohol-avoiding mouse strains, Crtam is identified as a candidate gene for alcohol preference.

  5. show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development.

  6. Necl2 (show CADM1 Proteins)/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system

  7. NK cells and T8 cells recognize Necl-2 (show CADM1 Proteins) through CRTAM, expressed only on activated cells. CRTAM-Necl-2 (show CADM1 Proteins) interactions promote cytotoxicity of NK cells and IFN-gamma (show IFNG Proteins) secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 (show CADM1 Proteins)

  8. CRTAM expression is critical for the accumulation of antigen-specific cytotoxic T lymphocytes and their subsequent proliferation within the draining lymph node.

CRTAM Protein Profile

Protein Summary

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008

Gene names and symbols associated with CRTAM

  • cytotoxic and regulatory T cell molecule (CRTAM)
  • cytotoxic and regulatory T cell molecule (crtam)
  • cytotoxic and regulatory T cell molecule (Crtam)
  • CD355 protein
  • CRTAM protein
  • cTADS protein
  • MGC82176 protein
  • TAD protein

Protein level used designations for CRTAM

cytotoxic and regulatory T-cell molecule , thymocyte activation and development protein , thymocyte activation and developmental protein , cytotoxic and regulatory T cell molecule , class-I MHC-restricted T cell associated molecule , cytotoxic and regulatory T-cell molecule-like , class I MHC restricted T cell associated molecule , class-I MHC-restricted T-cell-associated molecule , class I-restricted T cell-associated molecule

GENE ID SPECIES
395342 Gallus gallus
446606 Xenopus laevis
610296 Canis lupus familiaris
707560 Macaca mulatta
736196 Pan troglodytes
100390057 Callithrix jacchus
100461531 Pongo abelii
100606471 Nomascus leucogenys
56253 Homo sapiens
781864 Bos taurus
54698 Mus musculus
300649 Rattus norvegicus
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