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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Proteins (6) and DNMT3A Kits (2) and many more products for this protein.
Showing 10 out of 273 products:
Human Monoclonal DNMT3A Primary Antibody for ChIP, CyTOF - ABIN266067
Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002
Show all 83 Pubmed References
Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387881
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999
Show all 12 Pubmed References
Human Polyclonal DNMT3A Primary Antibody for ICC, IF - ABIN151733
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003
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Human Monoclonal DNMT3A Primary Antibody for ChIP, WB - ABIN2668262
Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. in Biochemical pharmacology 2011
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Mouse (Murine) Polyclonal DNMT3A Primary Antibody for IHC, WB - ABIN2668264
Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. in Nature neuroscience 2015
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Human Polyclonal DNMT3A Primary Antibody for IF (p), IHC (p) - ABIN669336
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
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Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387882
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Polyclonal DNMT3A Primary Antibody for WB - ABIN387865
ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012
Human Monoclonal DNMT3A Primary Antibody for FACS, ICC - ABIN252483
Sato, Kondo, Arai: The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. in Biochemical and biophysical research communications 2006
Human Polyclonal DNMT3A Primary Antibody for WB - ABIN2668283
Chang, Sun, Kokura, Horton, Fukuda, Espejo, Izumi, Koomen, Bedford, Zhang, Shinkai, Fang, Cheng: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. in Nature communications 2011
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a, Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
TP(thymidine phosphorylase (show TYMP Antibodies) ) curbed the expression of three proteins-IRF8 (show IRF8 Antibodies), RUNX2 (show RUNX2 Antibodies), and osterix (show SP7 Antibodies). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased the methyltransferase DNMT3A's expression.
alterations in DNMT3A and TET2 (show TET2 Antibodies) may be associated with acute myeloid leukemia (show BCL11A Antibodies) prognosis
Mutation in the DNMT3A gene is associated with acute myeloid leukemia (show BCL11A Antibodies) patients with lympho-myeloid clonal hematopoiesis.
These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.
This report represents the first documentation of the same variant (DNMT3A p.Arg882His) as both the constitutional mutation associated with TBRS and the somatic mutation hotspot of AML (show RUNX1 Antibodies).
Significantly lower DNMT1 (show DNMT1 Antibodies) and DNMT3A transcript levels in systemic lupus erythematosus patients were observed compared with healthy controls.
Mutations in genes associated with epigenetic regulations such as DNMT3A and ASXL1 (show ASXL1 Antibodies) seem to play an important role in the pathogenesis of CML (show BCR Antibodies) progression and TKI-resistance independent of ABL1 (show ABL1 Antibodies) KD mutations
Dnmt3a2 is at the core of memory processes and represents a novel target for cognition-enhancing therapies to ameliorate anxiety and fear disorders and boost memory consolidation.
Data indicate that DNMT3A allele G of rs1550117 was associated with an increased risk of non-small cell lung cancer (NSCLC) susceptibility and binding affinity of transcription repressor SP1 (show PSG1 Antibodies).
The results show that DNMT3A mutations are associated with an unfavourable clinical outcome in our Southeast Asian AML (show RUNX1 Antibodies) patient cohort.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Antibodies) were associated with several beef quality traits.
Loss of DNMT3A expression is associated with development of malignancy.
confirm the transformation potential of DNMT3A(R882H) Tet2 (show TET2 Antibodies)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (show TET2 Antibodies) inactivation driving lymphoid malignancies
overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (show TFAP2A Antibodies) knockdown.
These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.
in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.
Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (show FLT3 Antibodies) gene (Flt3 (show FLT3 Antibodies)(ITD)) and the nucleophosmin (show NPM1 Antibodies) gene (Npm1 (show GJA1 Antibodies)(c)) to induce AML (show RUNX1 Antibodies) in vivo, and promoted resistance to anthracycline chemotherapy.
miR (show MLXIP Antibodies)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR (show UTS2R Antibodies)). Our data reveal a novel mechanism of miR (show MLXIP Antibodies)-29a/b/c in the regulation of adipogenesis
DOT1L (show DOT1L Antibodies) may play a critical role in DNMT3A-mutant leukemia.
Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation (show HELLS Antibodies) during postnatal neurological development.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA