anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Antibodies

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Proteins (6) and DNMT3A Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNMT3A 1788 Q9Y6K1
DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Top anti-DNMT3A Antibodies at antibodies-online.com

Showing 10 out of 273 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Dnmt3a Pab (ABIN387881) in T47-D cell lysate. Dnmt3a (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Lysates from thymus tissue after radiation were subjected to WB using antibody against DNMT3a. CT, control animals. FR, animals subjected to fractionated exposure. AC, acutely exposed animals. All sample loading was normalized to protein content. Representative Western blots from three independent experiments are shown. each lane represents a protein extract of a thymus of one animal. (Mol. Cancer Res. 2005 Oct 01.3(10):553-561) 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat cell line lysates (35 µg/lane).DNMT3A(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of DNMT3A Antibody (C-term) (ABIN387865) in HepG2 cell line lysates (35 µg/lane). DNMT3A (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Dnmt3a Antibody (N-term R46) (ABIN387883) in Jurkat cell line lysates (35 µg/lane). Dnmt3a(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Dnmt3a antibody (N-term R46) (ABIN387883), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DNMT3A Antibody (C-term) in CEM cell line lysates (35ug/lane). This demonstrates the DNMT3A antibody detected the DNMT3A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DNMT3A Antibody (Center) in HL-60 cell line lysates (35ug/lane).This demonstrates the DNMT3A antibody detected the DNMT3A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details

DNMT3A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-DNMT3A Antibodies

  1. Human Monoclonal DNMT3A Primary Antibody for ChIP, CyTOF - ABIN266067 : Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002 (PubMed)
    Show all 83 Pubmed References

  2. Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387881 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999 (PubMed)
    Show all 12 Pubmed References

  3. Human Polyclonal DNMT3A Primary Antibody for ICC, IF - ABIN151733 : Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003 (PubMed)
    Show all 10 Pubmed References

  4. Human Monoclonal DNMT3A Primary Antibody for ChIP, WB - ABIN2668262 : Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. in Biochemical pharmacology 2011 (PubMed)
    Show all 3 Pubmed References

  5. Mouse (Murine) Polyclonal DNMT3A Primary Antibody for IHC, WB - ABIN2668264 : Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. in Nature neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal DNMT3A Primary Antibody for IF (p), IHC (p) - ABIN669336 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387882 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal DNMT3A Primary Antibody for WB - ABIN387865 : ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012 (PubMed)

  9. Human Monoclonal DNMT3A Primary Antibody for FACS, ICC - ABIN252483 : Sato, Kondo, Arai: The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. in Biochemical and biophysical research communications 2006 (PubMed)

  10. Human Polyclonal DNMT3A Primary Antibody for WB - ABIN2668283 : Chang, Sun, Kokura, Horton, Fukuda, Espejo, Izumi, Koomen, Bedford, Zhang, Shinkai, Fang, Cheng: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. in Nature communications 2011 (PubMed)

More Antibodies against DNMT3A Interaction Partners

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a, Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. TP(thymidine phosphorylase (show TYMP Antibodies) ) curbed the expression of three proteins-IRF8 (show IRF8 Antibodies), RUNX2 (show RUNX2 Antibodies), and osterix (show SP7 Antibodies). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased the methyltransferase DNMT3A's expression.

  2. alterations in DNMT3A and TET2 (show TET2 Antibodies) may be associated with acute myeloid leukemia (show BCL11A Antibodies) prognosis

  3. Mutation in the DNMT3A gene is associated with acute myeloid leukemia (show BCL11A Antibodies) patients with lympho-myeloid clonal hematopoiesis.

  4. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

  5. This report represents the first documentation of the same variant (DNMT3A p.Arg882His) as both the constitutional mutation associated with TBRS and the somatic mutation hotspot of AML (show RUNX1 Antibodies).

  6. Significantly lower DNMT1 (show DNMT1 Antibodies) and DNMT3A transcript levels in systemic lupus erythematosus patients were observed compared with healthy controls.

  7. Mutations in genes associated with epigenetic regulations such as DNMT3A and ASXL1 (show ASXL1 Antibodies) seem to play an important role in the pathogenesis of CML (show BCR Antibodies) progression and TKI-resistance independent of ABL1 (show ABL1 Antibodies) KD mutations

  8. Dnmt3a2 is at the core of memory processes and represents a novel target for cognition-enhancing therapies to ameliorate anxiety and fear disorders and boost memory consolidation.

  9. Data indicate that DNMT3A allele G of rs1550117 was associated with an increased risk of non-small cell lung cancer (NSCLC) susceptibility and binding affinity of transcription repressor SP1 (show PSG1 Antibodies).

  10. The results show that DNMT3A mutations are associated with an unfavourable clinical outcome in our Southeast Asian AML (show RUNX1 Antibodies) patient cohort.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (show DNMT3B Antibodies) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

  2. Loss of DNMT3A expression is associated with development of malignancy.

  3. confirm the transformation potential of DNMT3A(R882H) Tet2 (show TET2 Antibodies)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (show TET2 Antibodies) inactivation driving lymphoid malignancies

  4. overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (show TFAP2A Antibodies) knockdown.

  5. These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.

  6. in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.

  7. Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (show FLT3 Antibodies) gene (Flt3 (show FLT3 Antibodies)(ITD)) and the nucleophosmin (show NPM1 Antibodies) gene (Npm1 (show GJA1 Antibodies)(c)) to induce AML (show RUNX1 Antibodies) in vivo, and promoted resistance to anthracycline chemotherapy.

  8. miR (show MLXIP Antibodies)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR (show UTS2R Antibodies)). Our data reveal a novel mechanism of miR (show MLXIP Antibodies)-29a/b/c in the regulation of adipogenesis

  9. DOT1L (show DOT1L Antibodies) may play a critical role in DNMT3A-mutant leukemia.

  10. Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation (show HELLS Antibodies) during postnatal neurological development.

DNMT3A Antigen Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) antibody
  • DNA methyltransferase 3A (dnmt3a) antibody
  • DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a) antibody
  • DNA methyltransferase 3A (Dnmt3a) antibody
  • DNMT3A antibody
  • DNMT3A2 antibody
  • M.HsaIIIA antibody
  • MmuIIIA antibody

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPECIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
Selected quality suppliers for anti-DNMT3A (DNMT3A) Antibodies
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