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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Proteins (6) and DNMT3A Kits (3) and many more products for this protein.
Showing 10 out of 268 products:
Human Monoclonal DNMT3A Primary Antibody for ChIP, CyTOF - ABIN266067
Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002
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Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387881
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999
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Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951957
Park, Zeng, Steer: Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation. in Journal of cardiovascular translational research 2010
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Human Polyclonal DNMT3A Primary Antibody for EIA, WB - ABIN951956
Holz-Schietinger, Reich: The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. in The Journal of biological chemistry 2010
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Human Polyclonal DNMT3A Primary Antibody for IHC (p), WB - ABIN387882
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Polyclonal DNMT3A Primary Antibody for IF (p), IHC (p) - ABIN669336
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
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Human Polyclonal DNMT3A Primary Antibody for WB - ABIN387865
ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Antibodies), Dnmt3a, Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
we developed a CRISPR-Cas9-based tool for specific DNA methylation (show HELLS Antibodies) consisting of deactivated Cas9 (dCas9) nuclease (show DCLRE1C Antibodies) and catalytic domain of the DNA methyltransferase (show DNMT1 Antibodies) DNMT3A targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (show HELLS Antibodies) of a wider promoter region of the target loci IL6ST (show IL6ST Antibodies) and BACH2 (show BACH2 Antibodies) decreased their expression
TLR9 (show TLR9 Antibodies) upregulation in cases with episomal HPV16 was again higher among those with non-methylated immunostimulatory CpG motifs. Comparison of cases with HPV-negative controls revealed that DNMT3A was significantly downregulated only among integrated cases, DNMT3B (show DNMT3B Antibodies) was significantly overexpressed among both categories of cases, although at variable levels, while DNMT1 (show DNMT1 Antibodies) failed to show any deregulated expression among the cases
We identified frequent mutations of epigenetic modifiers, most notably mutations of DNMT3A, in 33% of adult MPAL (show SHCBP1 Antibodies) patients. Mutations of activated signaling pathways, tumor suppressors, and transcription factors were also frequent.
Participants with the high-risk genotype of DNMT1 (show DNMT1 Antibodies) rs8101626 and DNMT3A rs34048824 with concurrently high urinary total arsenic levels had even higher OR of clear cell renal cell carcinoma (show MOK Antibodies) in a dose-response manner
Findings suggest that hypomethylation is an initiating phenotype in acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) with DNMT3A(R882), while DNMT3A-dependent CpG island hypermethylation is a consequence of AML (show RUNX1 Antibodies) progression.
we demonstrate that persistence of DNMT3A R882 mutations during CR does not adversely impact long-term DFS (show FST Antibodies) and OS in AML (show RUNX1 Antibodies) patients.
the ability of TGF-beta1 (show TGFB1 Antibodies) to increase expression of both DNMT1 (show DNMT1 Antibodies) and DNMT3a demonstrates a novel means by which TGF-beta1 (show TGFB1 Antibodies) may regulate DNA methylation (show HELLS Antibodies) in these cells.
The de novo methyltransferases DNMT3A and 3B play a vital role in methylating the genome of the developing embryo in regions devoid of methylation marks.These observations suggest a potential interaction of G-quadruplexes with the DNA methylation (show HELLS Antibodies) machinery, which may be of epigenetic and biological significance
DNMT3A haploinsufficiency results in reversible epigenetic alterations that transform FLT3 (show FLT3 Antibodies)(ITD)-mutant myeloproliferative neoplasm into AML (show RUNX1 Antibodies).
DNMT1 (show DNMT1 Antibodies), DNMT3A and DNMT3B (show DNMT3B Antibodies) are highly expressed in human medulloblastoma samples
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Antibodies) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Antibodies) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Antibodies) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Antibodies) were associated with several beef quality traits.
this study shows that Dnmt3a enhances antiviral responses via a non-canonical mechanism to activate the kinase TBK1 (show TBK1 Antibodies) and the production of type I interferons in macrophages
While lens epithelial cell survival requires DNMT1 (show DNMT1 Antibodies), morphologically normal lenses develop in the absence of both DNMT3A and DNMT3B (show DNMT3B Antibodies).
observations suggested that Sept9 (show SEPT9 Antibodies) contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT (show DNMT1 Antibodies)-3a mediated methylation of Sept9 (show SEPT9 Antibodies)
Dnmt3a-cKO muscles exhibit fewer Pax7 (show PAX7 Antibodies)+ SCs (show TWIST1 Antibodies), which show increased expression of p57Kip2 (show CDKN1C Antibodies) protein
Study provides evidence that Arg882-mutated DNMT3A contributes to acute myeloid leukemia (show BCL11A Antibodies) pathogenesis through epigenetic activation of leukemia-related genes.
Dnmt3a is a haplo-insufficient (show TGFb Antibodies) tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 Antibodies)-G9a (show EHMT2 Antibodies)/GLP (show GOLGA6A Antibodies)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Antibodies) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML Antibodies)-RARA (show RARA Antibodies)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Antibodies) (APL (show FASL Antibodies)) required DNMT3A
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA