anti-Dedicator of Cytokinesis 8 (DOCK8) Antibodies

DOCK8 encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOCK8 81704 Q8NF50
DOCK8 76088 Q8C147
DOCK8 499337  
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Top anti-DOCK8 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: dedicator of cytokinesis 8 Antibody [NBP1-90452] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY404295) Immunocytochemistry/Immunofluorescence: dedicator of cytokinesis 8 Antibody [NBP1-90452] - Staining of human cell line U-2 OS shows positivity in nucleus, nucleus but not nucleoli & cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated IF, WB 100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemistry: dedicator of cytokinesis 8 Antibody (12D7) [NBP2-46470] - Analysis of Human liver tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Western Blot: dedicator of cytokinesis 8 Antibody (12D7) [NBP2-46470] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY cytokinesis 8. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated IHC Immunohistochemistry: dedicator of cytokinesis 8 Antibody (4F3) [NBP2-46469] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: dedicator of cytokinesis 8 Antibody (4F3) [NBP2-46469] - Analysis of Human pancreas tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB   100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB   100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p)   100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 16 Days
$460.63
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μg Log in to see 7 to 9 Days
$537.17
Details

DOCK8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , ,
,
,
Mouse (Murine)


Rat (Rattus)


Top referenced anti-DOCK8 Antibodies

  1. Human Polyclonal DOCK8 Primary Antibody for IHC, IHC (p) - ABIN4304781 : Jabara, McDonald, Janssen, Massaad, Ramesh, Borzutzky, Rauter, Benson, Schneider, Baxi, Recher, Notarangelo, Wakim, Dbaibo, Dasouki, Al-Herz, Barlan, Baris, Kutukculer, Ochs, Plebani, Kanariou et al.: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. ... in Nature immunology 2012 (PubMed)
    Show all 2 references for 4304781

More Antibodies against DOCK8 Interaction Partners

Human Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. Sequence analysis identified two copies of missense mutation, c.4346C > T, in the coding region of the DOCK8 gene in a family with 3 patients with autosomal recessive Hyper-IgE syndrome.

  2. Our results showed that DOCK8-deficient patients have a profound defect in TH17 differentiation related to decreased STAT3 (show STAT3 Antibodies) phosphorylation, translocation to the nucleus, and transcriptional activity

  3. The CD4 (show CD4 Antibodies)+ T-cell compartment is greatly altered in the absence of DOCK8. Specifically, DOCK8-deficient patients have increased TH2 cells and defects in TH1 (show TH1L Antibodies) and TH17 cell differentiation

  4. comparative study provides a long-term observation of DOCK8- and STAT3-hyper-IgE syndrome patients with regard to clinical and laboratory findings, and assesses the activation and cytokine secretion of lymphocytes after in vitro stimulation

  5. mutations in Chinese patients with hyper-IgE syndrome

  6. Letter/Case Report: DOCK8 homozygous mutation leading to primary immune deficiency.

  7. DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels.

  8. CD147 has a role in promoting Src (show SRC Antibodies)-dependent activation of Rac1 signaling through STAT3 (show STAT3 Antibodies)/DOCK8 during the motility of hepatocellular carcinoma cells

  9. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  10. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

Mouse (Murine) Dedicator of Cytokinesis 8 (DOCK8) interaction partners

  1. DOCK8 and WASp are in the same signaling pathway that links T-cell receptors (TCRs) to the actin cytoskeleton in TCR-driven actin assembly.

  2. LRCH1 (show LRCH1 Antibodies) as a novel effector to restrain PKCalpha (show PKCa Antibodies)-DOCK8-Cdc42 (show CDC42 Antibodies) module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).

  3. found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain

  4. DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4 (show CD4 Antibodies)(+) T-cell infiltration into HSV-infected skin.

  5. DOCK8 expression in the haematopoietic compartment is required for protective immunity and its deficiency results in drastic reduction of RORgammat+ innate lymphoid cells in the GI tract

  6. conclude that DOCK8 is an important regulator of DC migration during an immune response and is prone to mutations that disrupt its crucial function

  7. DOCK8-regulated shape integrity of lymphocytes prevents cytothripsis and promotes antiviral immunity in the skin.

  8. DOCK8 is required for the development and survival of mature NKT (show CTSL1 Antibodies) cells.

  9. DOCK8 regulates interstitial DC migration by controlling Cdc42 (show CDC42 Antibodies) activity spatially.

  10. Characterisation of the DOCK8-deficient mouse revealed T-cell lymphopenia, with increased T-cell turnover and decreased survival.

DOCK8 Antigen Profile

Protein Summary

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with DOCK8

  • dedicator of cytokinesis 8 (dock8) antibody
  • dedicator of cytokinesis 8 (DOCK8) antibody
  • dedicator of cytokinesis 8 (Dock8) antibody
  • 1200017A24Rik antibody
  • 5830472H07Rik antibody
  • A130095G14Rik antibody
  • AI461977 antibody
  • im:7154406 antibody
  • MRD2 antibody
  • si:dkey-91m11.1 antibody
  • ZIR8 antibody

Protein level used designations for DOCK8

dedicator of cytokinesis 8 , dedicator of cytokinesis protein 8-like , 1200017A24Rik , dedicator of cytokinesis protein 8

GENE ID SPECIES
403040 Danio rerio
427348 Gallus gallus
473156 Pan troglodytes
476333 Canis lupus familiaris
100050677 Equus caballus
100225500 Taeniopygia guttata
100295817 Bos taurus
100354750 Oryctolagus cuniculus
100393468 Callithrix jacchus
100463658 Ailuropoda melanoleuca
100153522 Sus scrofa
100565160 Anolis carolinensis
81704 Homo sapiens
76088 Mus musculus
499337 Rattus norvegicus
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