You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Deiodinase, Iodothyronine, Type II (DIO2) Antibodies

The protein encoded by DIO2 belongs to the iodothyronine deiodinase family. Additionally we are shipping DIO2 Kits (40) and DIO2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DIO2 13371 Q9Z1Y9
DIO2 1734 Q92813
DIO2 65162 P70551
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-DIO2 Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB AP17989PU-N DIO2 Antibody staining of Formalin Fixed and Paraffin Embedded Mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the mouse DIO2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of DIO2 Antibody (Center) in MCF-7 cell line lysates (35ug/lane). DIO2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated EIA, IHC (p) 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Goat Un-conjugated IHC, ELISA, WB ABIN190862 (2µg/ml) staining of cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of DIO2 Antibody (Center) (ABIN652664) in MCF-7 cell line lysates (35 µg/lane). DIO2 (arrow) was detected using the purified polyclonal antibody. DIO2 Antibody (Center) (ABIN652664) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (pfa), ELISA 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$396.00
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$418.00
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

DIO2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , , ,
,

, , , , , , , , , , ,
Human , , , ,
,

, , , , , , , , , , , , , ,
Rat (Rattus) , , , ,
,

, , , , , , , , , , ,

Top referenced anti-DIO2 Antibodies

  1. Human Polyclonal DIO2 Primary Antibody for EIA, IHC (p) - ABIN453620 : He, Li, Wang, Ju, Lu, Shi, He, Zhong: Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population. in Progress in neuro-psychopharmacology & biological psychiatry 2009 (PubMed)
    Show all 2 references for ABIN453620

  2. Mouse (Murine) Polyclonal DIO2 Primary Antibody for IHC, ELISA - ABIN190862 : Gumieniak, Perlstein, Williams, Hopkins, Brown, Raby, Williams: Ala92 type 2 deiodinase allele increases risk for the development of hypertension. in Hypertension 2007 (PubMed)
    Show all 2 references for ABIN190862

More Antibodies against DIO2 Interaction Partners

Zebrafish Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. This study investigated deiodinase 1 (Dio1 (show DIO1 Antibodies)), deiodinase 2 (Dio2), and deiodinase 3 (Dio3 (show DIO3 Antibodies)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.

Xenopus laevis Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.

Mouse (Murine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Mice subjected to a running regime have significant increased cartilage damage and synovitis scores. Lack of Dio2 protected against cartilage damage in this model and was reflected in a specific gene expression profile.

  2. Data show that type 2 deiodinase (Dio2) inactivation in skeletal myocytes preserves T3 thyroid hormone (show PTH Antibodies) content and only mildly disrupts thyroid hormone (show PTH Antibodies) signaling.

  3. These studies reveal that tissue-specific differences in D2 ubiquitination are an inherent property of the TRH/TSH feedback mechanism

  4. congenital severe reduction of thyrotroph Dio2 causes a major impairment of the TSH response to hypothyroidism

  5. Systemic changes in thyroid hormone (show PTH Antibodies) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type 4 and type 3 in tissues and their enhanced metabolism by deiodinase D3.

  6. Data indicate that deiodinase Dio2 was mainly localized in stroma cells before implantation, whereas deiodinase Dio3 (show DIO3 Antibodies) was highly expressed in stromal cells after implantation.

  7. Data suggest that hepatic deiodinase type 2 (D2) favors the innate immune response by specifically regulating cellular thyroid hormone (show PTH Antibodies) levels in macrophages.

  8. Data suggest that type 2 deiodinase is induced in inflammation of tanycytes (as in inflammation of periventricular area, arcuate nucleus, and median eminence of hypothalamus); this enzyme induction appears to involve NFkappaB signaling.

  9. Data suggest that type 2 deiodinase induction (and kinetics of induction) in animal models of inflammation of leptomeninges, choroid plexus, and brain blood vessels is tissue specific and species specific.

  10. assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone (show PTH Antibodies) regulation, is increased in resilience to stress-induced depressive syndrome

Human Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. the reduction of SAT DIO2 expression is negatively correlated with DBP and TG levels that are associated with the MetS. This might have an effect on developing MetS.

  2. In subjects who are alcohol dependent, the rs225014 DIO2 gene was associated with significant differences in the amount of naturalistic alcohol drinking.

  3. Data provide evidence in humans that genetic predisposition combined with early osteoarthritis-related changes results in loff of epigenetic silencing of DIO2.

  4. DIO2 gene plays a role in the etiology of recurrent depressive disorder.Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder.

  5. DIO2 gene polymorphisms may play a role in the incidence of MCI (show MCIN Antibodies) in male patients.

  6. conversion of T4 to T3 by D2 is required for TRalpha1/PI3K (show PIK3CA Antibodies)-mediated nongenomic actions of T4 in HUVECs, including stimulation of Akt (show AKT1 Antibodies) phosphorylation and Rac (show AKT1 Antibodies) activation, which result in cell migration.

  7. Thyroid hormone (show PTH Antibodies) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Antibodies) exposure.

  8. The rs225017 polymorphism in the 3'UTR (show UTS2R Antibodies) of the human DIO2 gene is associated with increased insulin (show INS Antibodies) resistance.

  9. Identification of two heterozygous nonsynonymous mutations in the thyroid hormone (show PTH Antibodies) activating type 2 deiodinase.

  10. Molecular genetic markers of predisposition to the development of thyroid disease are: GG genotype and allele G gene DIO2 (274A > G), CT and CC genotypes of the gene CYP1A1 (show CYP1A1 Antibodies) (-3798T > C), associated with the development of nodular goiter

Pig (Porcine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

Cow (Bovine) Deiodinase, Iodothyronine, Type II (DIO2) interaction partners

  1. Increased expression of mammary TRbeta1 (show THRB Antibodies) and DIO2, and decreased RXRalpha (show RXRA Antibodies), provide a mechanism to increase thyroid hormone (show PTH Antibodies) activity within the mammary gland during lactation.

DIO2 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DIO2

  • deiodinase, iodothyronine, type II (DIO2) antibody
  • deiodinase, iodothyronine, type II (dio2) antibody
  • type II iodothyronine deiodinase (LOC100135896) antibody
  • deiodinase, iodothyronine, type II (LOC100224791) antibody
  • deiodinase, iodothyronine, type II (LOC100354221) antibody
  • type II iodothyronine deiodinase (dio2-A) antibody
  • deiodinase, iodothyronine, type 2 (dio2) antibody
  • deiodinase, iodothyronine, type II (Dio2) antibody
  • 5DII antibody
  • AI324267 antibody
  • cb684 antibody
  • D2 antibody
  • Deio2 antibody
  • DIO2 antibody
  • dio2-A antibody
  • DIOII antibody
  • SelY antibody
  • TXDI2 antibody

Protein level used designations for DIO2

type II iodothyronine deiodinase , D2 , deiodinase, iodothyronine, type II , iodothyronine type II deiodinase , deiodinase 2 , deiodinase, iodothyronine, type 2 , type 2 deiodinase , type 2 DI , type-II 5' deiodinase , type-II 5'-deiodinase , thyroxine deiodinase, type II , type 2 iodothyronine deiodinase , type-II 5'deiodinase , 5DII , DIOII

GENE ID SPECIES
100052547 Equus caballus
352937 Danio rerio
467521 Pan troglodytes
707484 Macaca mulatta
100101569 Oryctolagus cuniculus
100135896 Oncorhynchus mykiss
100224791 Taeniopygia guttata
100310793 Ovis aries
100354221 Oryctolagus cuniculus
373842 Xenopus laevis
100036737 Xenopus (Silurana) tropicalis
13371 Mus musculus
1734 Homo sapiens
414379 Sus scrofa
65162 Rattus norvegicus
490813 Canis lupus familiaris
494548 Bos taurus
373903 Gallus gallus
100721073 Cavia porcellus
Selected quality suppliers for anti-DIO2 (DIO2) Antibodies
Did you look for something else?