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The protein encoded by DIO2 belongs to the iodothyronine deiodinase family. Additionally we are shipping DIO2 Kits (40) and DIO2 Proteins (8) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal DIO2 Primary Antibody for EIA, IHC (p) - ABIN453620
He, Li, Wang, Ju, Lu, Shi, He, Zhong: Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population. in Progress in neuro-psychopharmacology & biological psychiatry 2009
Show all 2 references for ABIN453620
Mouse (Murine) Polyclonal DIO2 Primary Antibody for IHC, ELISA - ABIN190862
Gumieniak, Perlstein, Williams, Hopkins, Brown, Raby, Williams: Ala92 type 2 deiodinase allele increases risk for the development of hypertension. in Hypertension 2007
Show all 2 references for ABIN190862
This study investigated deiodinase 1 (Dio1 (show DIO1 Antibodies)), deiodinase 2 (Dio2), and deiodinase 3 (Dio3 (show DIO3 Antibodies)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.
Mice subjected to a running regime have significant increased cartilage damage and synovitis scores. Lack of Dio2 protected against cartilage damage in this model and was reflected in a specific gene expression profile.
Data show that type 2 deiodinase (Dio2) inactivation in skeletal myocytes preserves T3 thyroid hormone (show PTH Antibodies) content and only mildly disrupts thyroid hormone (show PTH Antibodies) signaling.
These studies reveal that tissue-specific differences in D2 ubiquitination are an inherent property of the TRH/TSH feedback mechanism
congenital severe reduction of thyrotroph Dio2 causes a major impairment of the TSH response to hypothyroidism
Systemic changes in thyroid hormone (show PTH Antibodies) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type 4 and type 3 in tissues and their enhanced metabolism by deiodinase D3.
Data indicate that deiodinase Dio2 was mainly localized in stroma cells before implantation, whereas deiodinase Dio3 (show DIO3 Antibodies) was highly expressed in stromal cells after implantation.
Data suggest that hepatic deiodinase type 2 (D2) favors the innate immune response by specifically regulating cellular thyroid hormone (show PTH Antibodies) levels in macrophages.
Data suggest that type 2 deiodinase is induced in inflammation of tanycytes (as in inflammation of periventricular area, arcuate nucleus, and median eminence of hypothalamus); this enzyme induction appears to involve NFkappaB signaling.
Data suggest that type 2 deiodinase induction (and kinetics of induction) in animal models of inflammation of leptomeninges, choroid plexus, and brain blood vessels is tissue specific and species specific.
assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone (show PTH Antibodies) regulation, is increased in resilience to stress-induced depressive syndrome
In subjects who are alcohol dependent, the rs225014 DIO2 gene was associated with significant differences in the amount of naturalistic alcohol drinking.
Data provide evidence in humans that genetic predisposition combined with early osteoarthritis-related changes results in loff of epigenetic silencing of DIO2.
DIO2 gene plays a role in the etiology of recurrent depressive disorder.Association of the DIO2 gene single nucleotide polymorphisms with recurrent depressive disorder.
DIO2 gene polymorphisms may play a role in the incidence of MCI (show MCIN Antibodies) in male patients.
conversion of T4 to T3 by D2 is required for TRalpha1/PI3K (show PIK3CA Antibodies)-mediated nongenomic actions of T4 in HUVECs, including stimulation of Akt (show AKT1 Antibodies) phosphorylation and Rac (show AKT1 Antibodies) activation, which result in cell migration.
Thyroid hormone (show PTH Antibodies) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (show PTH Antibodies) exposure.
The rs225017 polymorphism in the 3'UTR (show UTS2R Antibodies) of the human DIO2 gene is associated with increased insulin (show INS Antibodies) resistance.
Identification of two heterozygous nonsynonymous mutations in the thyroid hormone (show PTH Antibodies) activating type 2 deiodinase.
Molecular genetic markers of predisposition to the development of thyroid disease are: GG genotype and allele G gene DIO2 (274A > G), CT and CC genotypes of the gene CYP1A1 (show CYP1A1 Antibodies) (-3798T > C), associated with the development of nodular goiter
[review] D2 variants correlate with thyroid hormone (show PTH Antibodies) levels, insulin (show INS Antibodies) resistance, bipolar mood disorder, psychological well-being, mental retardation, hypertension, and risk for osteoarthritis.
Increased expression of mammary TRbeta1 (show THRB Antibodies) and DIO2, and decreased RXRalpha (show RXRA Antibodies), provide a mechanism to increase thyroid hormone (show PTH Antibodies) activity within the mammary gland during lactation.
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
type II iodothyronine deiodinase
, deiodinase, iodothyronine, type II
, iodothyronine type II deiodinase
, deiodinase 2
, deiodinase, iodothyronine, type 2
, type 2 deiodinase
, type 2 DI
, type-II 5' deiodinase
, type-II 5'-deiodinase
, thyroxine deiodinase, type II
, type 2 iodothyronine deiodinase
, type-II 5'deiodinase