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Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. Additionally we are shipping DMBT1 Kits (8) and DMBT1 Proteins (2) and many more products for this protein.
Showing 10 out of 51 products:
Data suggest that DMBT1 is secreted by oviduct epithelium and plays role in sperm-ovum interactions during in vitro fertilization.
a novel role for interleukin-27 (IL-27 (show IL27 Antibodies)) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1 (show IDO1 Antibodies)
DMBT1 functions as an important endothelium-derived ECM (show MMRN1 Antibodies) protein that is able to bind angiogenic factors and promote adhesion, migration, proliferation, and angiogenesis as well as vascular repair.
Data show that deletion of hensin from intercalated cells results in the absence of typical alpha-intercalated cells and the consequent development of complete distal renal tubular acidosis (dRTA).
Carboxyl-terminal Asp (show C3 Antibodies)(D) -3, Thr (show TRH Antibodies)(T) -2, Lys (show LYZ Antibodies)(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 (show SLC9A3R1 Antibodies) and PDZK1/CAP70 (show PDZK1 Antibodies).
binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D (show SFTPD Antibodies)
Muclin is a Golgi cargo receptor that binds to regulated secretory proteins under the mildly acidic pH conditions that exist in the trans-Golgi network
Mouse embryonic stem cells seeded on hensin formed hemispheric epithelial structures whose outermost layer terminally differentiated to an epithelium that resembled the visceral endoderm.
The results identify a novel mammary tumor susceptibility locus in mice and support a role for DMBT1 in suppression of mammary tumors in both mice and women.
Dmbt1(-/-) mice display enhanced susceptibility to dextran sulfate sodium-induced colitis and elevated Tnf (show TNF Antibodies), Il6 (show IL6 Antibodies), and Nod2 (show NOD2 Antibodies) expression levels during inflammation.
Muclin deficiency impairs trafficking of regulated proteins to a stimulus-releasable pool in the exocrine pancreas
SALSA, together with fibronectin (show FN1 Antibodies) and C1q, may be involved in the containment of injured placental structures into fibrinoids.
The DMBT1 may play a role in epithelial differentiation and local innate immunity during neonatal inflammatory bowel processes.
Data indicate that DMBT1 promotes VEGF (show VEGFA Antibodies) and suppresses IL-6 (show IL6 Antibodies) production in alveolar tissues, which could point to DMBT1 having a possible role in the transition from inflammation to regeneration.
Gp340 expression patterns at these sites were also distinct.
multiallelic copy number variation (CNV) within DMBT1 is extensive across all populations.
gp340 exhibits varying functions in the different mucosal locations.
Oral streptococci adhere to tooth-immobilized glycoprotein 340 (GP340) via the surface protein antigen I/II as the first step in pathogenesis. Calcium increases the conformational stability of the scavenger-rich cysteine repeat domains of GP340.
A novel functional role of rs2981804 in regulating DMBT1 expression.
interaction between DMBT1(gp340) and trefoil (show TFF3 Antibodies) TFFs proteins was investigated using an ELISA assay. DMBT1(gp340) bound to solid-phase bound recombinant dimeric TFF3 (show TFF3 Antibodies) in a calcium dependent manner
Up-regulated DMBT1 and complement activation in cardiac amyloidosis may be part of the activated pathways induced by protein aggregation and the consecutive inflammatory reaction
Involvement of AKAP4 (show AKAP4 Antibodies) in the formation of the fibrous sheath on boar precursor sperm cells and the phosphorylation of pro-AKAP4 (show AKAP4 Antibodies) as an early step in the signal transduction pathway gated by DMBT1 that leads to sperm selection through acrosome alteration.
Demonstrate that galectin-3 (show LGALS3 Antibodies) plays a critical role in hensin ECM (show MMRN1 Antibodies) assembly by oligomerizing secreted monomeric hensin.
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.
deleted in malignant brain tumors 1
, hypothetical protein
, deleted in malignant brain tumors 1 protein
, deleted in malignant brain tumors 1 pseudogene
, glycoprotein 300
, mucin-like glycoprotein
, glycoprotein 340
, salivary agglutinin
, surfactant pulmonary-associated D-binding protein