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anti-Docking Protein 7 (DOK7) Antibodies

The protein encoded by DOK7 is essential for neuromuscular synaptogenesis. Additionally we are shipping DOK7 Proteins (3) and DOK7 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOK7 285489 Q18PE1
DOK7 231134 Q18PE0
DOK7 305448  
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Top anti-DOK7 Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated WB DOK7 Antibody (N-term) (ABIN657491) western blot analysis in mouse spleen tissue lysates (35 µg/lane). This demonstrates the DOK7 antibody detected the DOK7 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from mouse brain cells, using DOK7 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DOK7 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IF, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK7. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-DOK7 mouse monoclonal antibody (ABIN2455816) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DOK7 (RC219267). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK7. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK7. Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-DOK7 mouse monoclonal antibody. (ABIN2455815) 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC219267 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DOK7 antibody (ABIN2455833), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK7. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC219267 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DOK7 antibody (ABIN2455843), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK7. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-DOK7 mouse monoclonal antibody (ABIN2455821) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DOK7 (RC219267). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOK7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DOK7. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details

DOK7 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine) ,
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Rat (Rattus)

Top referenced anti-DOK7 Antibodies

  1. Mouse (Murine) Polyclonal DOK7 Primary Antibody for WB - ABIN657491 : Bergamin, Hallock, Burden, Hubbard: The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. in Molecular cell 2010 (PubMed)
    Show all 2 references for ABIN657491

  2. Human Polyclonal DOK7 Primary Antibody for IF, IHC - ABIN1533938 : Beeson, Higuchi, Palace, Cossins, Spearman, Maxwell, Newsom-Davis, Burke, Fawcett, Motomura, Müller, Lochmüller, Slater, Vincent, Yamanashi: Dok-7 mutations underlie a neuromuscular junction synaptopathy. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 2 references for ABIN1533938

More Antibodies against DOK7 Interaction Partners

Zebrafish Docking Protein 7 (DOK7) interaction partners

  1. Dok-7 promotes slow muscle integrity as well as neuromuscular junction formation in a zebrafish model of congenital myasthenic syndromes.

Human Docking Protein 7 (DOK7) interaction partners

  1. Individuals with DOK7 congenital myasthenic syndrome displayed stridor and feeding difficulties at birth or progressive weakness despite normal milestones in infancy pointing to a diagnosis and should lead to neurophysiological and genetic investigation

  2. this study demonistrated that Salbutamol is an effective treatment in patient wity congenital myasthenic syndrome due to DOK7 mutation.

  3. DOK7 limb-girdle myasthenic syndrome can mimick congenital muscular dystrophy.

  4. Hypermethylation of DOK7 occurs years before tumor diagnosis, suggesting a role as a powerful epigenetic blood-based biomarker as well as providing insights into breast cancer pathogenesis

  5. In contrast to AChR deficiency due to epsilon subunit (show CHRNE Antibodies) mutations, onset of DOK7 CMS (show Cd2ap Antibodies) tends to be later--ages two to three years--and in DOK7 CMS (show Cd2ap Antibodies) eye movements are usually spared and anticholinesterases can exacerbate the weakness

  6. The DOK7 gene is highly polymorphic, and within these many variants, a spectrum of mutations that can underlie DOK7 Congenital myasthenic syndromes that will inform in managing this disorder, were defined.

  7. Sequencing of DOK-7 in seronegative myasthenia gravis patients reveals no mutations.

  8. 6 CMS (show Cd2ap Antibodies) patients with DOK7 mutations had congenital stridor, bilateral vocal cord palsy and difficulty with feeding

  9. This study demonistreated that DOK7 mutation casused congenital myasthenic syndrome in French Canadians.

  10. these findings demonstrate that missense mutations in MUSK (show MUSK Antibodies) can result in a severe form of congenital myasthenic syndrome and indicate that the inability of MuSK (show MUSK Antibodies) mutants to interact with Dok-7.

Mouse (Murine) Docking Protein 7 (DOK7) interaction partners

  1. Protein kinase CK2 (show CSNK2A1 Antibodies) interacts at the neuromuscular synapse with Rapsyn (show RAPSN Antibodies), Rac1, 14-3-3gamma (show YWHAG Antibodies), and Dok-7 proteins and phosphorylates the latter two.

  2. Sp1 (show SP1 Antibodies) plays a crucial role in the regulation of the dok-7 gene.

  3. Data show a critical role for Crk (show CRK Antibodies) and Crk (show CRK Antibodies)-L downstream from Dok-7 in presynaptic and postsynaptic differentiation.

  4. The crystal structure of the Dok7 PH-PTB (show PTBP1 Antibodies) domains in complex with a phosphopeptide representing the Dok7-binding site on MuSK (show MUSK Antibodies), is presented.

  5. Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK (show MUSK Antibodies)

  6. the COOH-terminal NES (show NES Antibodies) and Src (show SRC Antibodies) homology 2 target motifs play key roles in Dok-7/MuSK (show MUSK Antibodies) signaling for neuromuscular synaptogenesis.

DOK7 Antigen Profile

Protein Summary

The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with DOK7

  • docking protein 7 (DOK7) antibody
  • docking protein 7 (dok7) antibody
  • docking protein 7 (Dok7) antibody
  • downstream of tyrosine kinase 7 (dok7) antibody
  • A930013K19Rik antibody
  • AW049091 antibody
  • C4orf25 antibody
  • CMS1B antibody
  • dok-7 antibody
  • EF-12 antibody
  • Oit5 antibody
  • RGD1566416 antibody
  • si:ch211-164d19.2 antibody
  • si:dkey-180b4.3 antibody

Protein level used designations for DOK7

docking protein 7 , downstream of tyrosine kinase 7 , protein Dok-7 , oncoprotein induced transcript 5

GENE ID SPECIES
422875 Gallus gallus
488794 Canis lupus familiaris
524590 Bos taurus
557881 Danio rerio
750536 Pan troglodytes
285489 Homo sapiens
231134 Mus musculus
305448 Rattus norvegicus
724073 Takifugu rubripes
Selected quality suppliers for anti-DOK7 (DOK7) Antibodies
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