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Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (By simi. Additionally we are shipping Exostoses (Multiple)-Like 2 Proteins (7) and and many more products for this protein.
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Human Polyclonal EXTL2 Primary Antibody for EIA, WB - ABIN952146
Kaidonis, Liaw, Roberts, Ly, Anson, Byers: Gene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses. in European journal of human genetics : EJHG 2010
Show all 2 references for ABIN952146
EXTL2 controls liver regeneration and aortic calcification through xylose kinase (show FAM20B Antibodies)-dependent regulation of glycosaminoglycan biosynthesis.[review]
EXTL2-mediated regulation of glycosaminoglycans synthesis is important for tissue regeneration processes following liver injury.
EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase (show FAM20B Antibodies) and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans
crystal structure of EXTL2
Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL2 gene silencing.
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (By similarity).
EXT-related protein 2
, alpha-1,4-N-acetylhexosaminyltransferase EXTL2
, alpha-GalNAcT EXTL2
, exostoses-like 2
, exostosin-like 2
, exotoses (multiple)-like 2
, glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
, exostoses (multiple)-like 2
, processed exostosin-like 2