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Farnesyl-Diphosphate Farnesyltransferase 1 Proteins (FDFT1)

FDFT1 encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. Additionally we are shipping FDFT1 Antibodies (99) and FDFT1 Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FDFT1 14137 P53798
FDFT1 29580 Q02769
FDFT1 2222 P37268
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Top FDFT1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$745.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$806.30
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details

FDFT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Rat (Rattus)

Human , , ,
, ,

More Proteins for Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) Interaction Partners

Mouse (Murine) Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) interaction partners

  1. This study demonistrated that fdft1 is regulate the neuronal cholesterol synthesis during neurite outgrowth.

  2. Result provides the first in vivo evidence that SS plays a regulatory role in cholesterol metabolism through modulation of HMG-CoA reductase (show HMGCR Proteins) activity and cholesterol biosynthesis.

  3. VEGF (show VEGFA Proteins) expression, APOPTOSIS, AND ANGIOGENESIS in squalene synthase -ablated neural stem cells wERE strongly upregulated

Human Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) interaction partners

  1. The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C.

  2. Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor (show TNFRSF1A Proteins) 1 and nuclear factor-kappaB activation and matrix metallopeptidase (show ECEL1 Proteins) 1 expression.

  3. Several critical residues that are involved in binding of NADPH (show NQO1 Proteins) have been identified in the active site of squalene synthase.

  4. HCV infection increases FDFT1 protein level but not FDFT1 mRNA level.

  5. ABHD5 (show ABHD5 Proteins), PGRMC1 (show PGRMC1 Proteins) and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features.

  6. FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes.

  7. CTSB (show CTSB Proteins) and FDFT1 are excluded as candidates for keratolytic winter erythema

  8. NASH (show SAMSN1 Proteins) is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.

  9. In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin (show HBB Proteins), the NAFLD activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1)

  10. Results report the high-resolution x-ray structures of human farnesyl pyrophosphate synthase (show FDPS Proteins) in complexes with risedronate and zoledronate, two of the leading nitrogen-containing bisphosphonates in clinical use.

FDFT1 Protein Profile

Protein Summary

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

Gene names and symbols associated with FDFT1

  • farnesyl-diphosphate farnesyltransferase 1 (FDFT1)
  • farnesyl-diphosphate farnesyltransferase 1 (fdft1)
  • farnesyl-diphosphate farnesyltransferase 1 (LOC100217567)
  • farnesyl diphosphate farnesyl transferase 1 (Fdft1)
  • farnesyl-diphosphate farnesyltransferase 1 (Fdft1)
  • si:ch73-107c13.2 (si:ch73-107c13.2)
  • DGPT protein
  • DKFZp459C1712 protein
  • ERG9 protein
  • fdft1 protein
  • SQS protein
  • SS protein

Protein level used designations for FDFT1

farnesyl-diphosphate farnesyltransferase 1 , squalene synthase , SS , SQS , Squalene synthetase , FPP:FPP farnesyltransferase , squalene synthase-like , farnesyl-diphosphate farnesyltransferase , squalene synthetase , farnesyl diphosphate farnesyltransferase , presqualene-di-diphosphate synthase

GENE ID SPECIES
696396 Macaca mulatta
740684 Pan troglodytes
100029000 Monodelphis domestica
100173463 Pongo abelii
100216201 Xenopus (Silurana) tropicalis
100479603 Ailuropoda melanoleuca
100560926 Anolis carolinensis
100603333 Nomascus leucogenys
100217567 Taeniopygia guttata
14137 Mus musculus
29580 Rattus norvegicus
422038 Gallus gallus
2222 Homo sapiens
477362 Canis lupus familiaris
100312971 Sus scrofa
281767 Bos taurus
100345480 Oryctolagus cuniculus
100714445 Cavia porcellus
101119109 Ovis aries
571911 Danio rerio
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