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The protein encoded by FAF2 is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. Additionally we are shipping Fas Associated Factor Family Member 2 Proteins (8) and Fas Associated Factor Family Member 2 Kits (5) and many more products for this protein.
Showing 10 out of 53 products:
Human Polyclonal FAF2 Primary Antibody for WB - ABIN525021
Lee, Zhang, Feramisco, Gong, Ye: Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. in The Journal of biological chemistry 2008
Show all 3 references for ABIN525021
Human Polyclonal FAF2 Primary Antibody for ELISA, WB - ABIN185060
Imai, Nakada, Hashida, Sugita, Tanaka, Tsujimoto, Matsumoto, Akasawa, Saito, Oshida: Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. in Biochemical and biophysical research communications 2002
role of UBXD8 in cellular responses to excess fatty acids
the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids
UBXD8-mediated recruitment of p97/VCP (show vcp Antibodies) to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)), the rate-limiting enzyme in triacylglycerol hydrolysis.
Ubx2 and Ubxd8 regulates lipid droplet homeostasis.
These results indicate that ApoB (show APOB Antibodies) after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 (show DERL1 Antibodies) and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.
These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids.
These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP (show RASA1 Antibodies) proteins Ira2 (in yeast) and neurofibromin (show NF1 Antibodies) (in humans).
ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients
Depletion of UBXD8 in hepatocytes suppresses VLDL secretion, and could lead to periportal steatosis when mice are fed a high-fat diet.
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
Fas associated factor family member 2
, UBX domain containing 8
, FAS-associated factor 2-like
, FAS-associated factor 2
, UBX domain protein 3B
, UBX domain-containing protein 3B
, UBX domain-containing protein 8
, expressed in T-cells and eosinophils in atopic dermatitis
, protein expressed in T-cells and eosinophils in atopic dermatitis
, FAS-associated factor 2-A
, UBX domain-containing protein 8-A