anti-Fragile Histidine Triad (FHIT) Antibodies

FHIT, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Additionally we are shipping FHIT Proteins (37) and FHIT Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FHIT 2272 P49789
FHIT 60398 Q9JIX3
FHIT 14198 O89106
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Top anti-FHIT Antibodies at antibodies-online.com

Showing 10 out of 136 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-FHIT Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human kidney WB Suggested Anti-FHIT <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- FHIT Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti- FHIT Picoband antibody, Western blotting All lanes: Anti FHIT  at 0.5ug/ml WB: Recombinant Human FHIT Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FHIT (Phospho-Tyr114) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat kidney labeled with Anti-FHIT Polyclonal Antibody, Unconjugated (ABIN734198) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of FHIT on mouse liver lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-FHIT. Immunofluorescent staining of L6 cells. 50 μg Log in to see 6 to 8 Days
$220.08
Details
Human Mouse Un-conjugated WB FHIT monoclonal antibody (M01), clone 1E3 Western Blot analysis of FHIT expression in HL-60. Detection limit for recombinant GST tagged FHIT is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged FHIT is approximately 3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: FHIT Antibody [NBP1-89062] - Staining of human kidney shows strong cytoplasmic positivity in tubular cells. Western Blot: FHIT Antibody [NBP1-89062] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY419588) 0.1 mL Log in to see 10 to 13 Days
$439.69
Details

FHIT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FHIT Antibodies

  1. Mouse (Murine) Monoclonal FHIT Primary Antibody for IF, WB - ABIN968653 : Fong, Fidanza, Zanesi, Lock, Siracusa, Mancini, Siprashvili, Ottey, Martin, Druck, McCue, Croce, Huebner: Muir-Torre-like syndrome in Fhit-deficient mice. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FHIT Primary Antibody for IHC, IHC (p) - ABIN4311628 : Diaz, Guduk, Romagnuolo, Smith, Northcott, Shih, Berisha, Flanagan, Munoz, Cusimano, Pamir, Rutka: High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis. in Neoplasia (New York, N.Y.) 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal FHIT Primary Antibody for IF (p), IHC (p) - ABIN734198 : Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010 (PubMed)

More Antibodies against FHIT Interaction Partners

Human Fragile Histidine Triad (FHIT) interaction partners

  1. This study demonstrates that Fhit down-regulation is an early event in both multistep carcinogenic processes leading to pancreatic ductal adenocarcinoma

  2. The results have implications for the mechanism by which Fhit regulates TK1 (show TK1 Antibodies) mRNA, and more broadly, for its modulation of multiple functions as tumor suppressor/genome caretaker.

  3. RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings.

  4. The peptide was located within the 'disordered' region, which is invisible in the known crystal structures of Fhit.

  5. Both the 3p14.2 locus copy number and FHIT protein expression levels showed significant decreases when CIN (show PDXP Antibodies) transitioned to cervical cancer.

  6. Study indicate that the observed level of FHIT promoter methylation was not enough to suppress gene expression in non-small cell lung cancer (NSCLC). Lack of negative correlation between FHIT expression and methylation, or positive correlation between gene expression and immunoexpression suggest the role of another molecular mechanisms regulating FHIT expression on mRNA and protein levels in NSCLC patients.

  7. High methylation in the FHIT promoter region is associated with lung cancer.

  8. the expression profile of miRNAs that may be associated with expression of the FHIT gene in breast cancer, was examined.

  9. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential drug target of non-small cell lung cancer.

  10. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential diagnostic marker and drug target of non-small-cell lung carcinoma

Cow (Bovine) Fragile Histidine Triad (FHIT) interaction partners

  1. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors

Mouse (Murine) Fragile Histidine Triad (FHIT) interaction partners

  1. Fhit loss and subsequent thymidine kinase 1 (show TK1 Antibodies) inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo

  2. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient.

  3. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

  4. Fhit delocalizes annexin A4 (show ANXA4 Antibodies) from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

  5. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability.

  6. Loss of Fhit expression contributes to cell transformation.

  7. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance.

  8. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg (show PTPRG Antibodies) and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements

  9. Association of Fhit gene inactivation with increased survival after DNA damage, related to over-active checkpoints regulated by ATR/CHK1 pathway. Potential effects of Fhit-dependent DNA damage response on tumor progression.

  10. Fhit has a role in bladder cancer development

FHIT Antigen Profile

Protein Summary

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with FHIT

  • fragile histidine triad (FHIT) antibody
  • fragile histidine triad gene (FHIT) antibody
  • fragile histidine triad (Fhit) antibody
  • fragile histidine triad gene (fhit) antibody
  • fragile histidine triad gene (Fhit) antibody
  • fragile histidine triad (fhit) antibody
  • fragile histidine triad gene (LOC100223655) antibody
  • fragile histidine triad protein (PY07476) antibody
  • AP3Aase antibody
  • AW045638 antibody
  • FHIT antibody
  • FRA3B antibody
  • Fra14A2 antibody
  • LOC100223655 antibody
  • zgc:73176 antibody

Protein level used designations for FHIT

AP3A hydrolase , bis(5'-adenosyl)-triphosphatase , diadenosine 5',5'''-P1,P3-triphosphate hydrolase , dinucleosidetriphosphatase , tumor suppressor protein , AP3Aase , fragile histidine triad protein , fragile histidine triad gene , diadenosine triphosphate hydrolase , fragile histidine triad

GENE ID SPECIES
2272 Homo sapiens
100215999 Canis lupus familiaris
692183 Bos taurus
60398 Rattus norvegicus
100307043 Ovis aries
393713 Danio rerio
14198 Mus musculus
448702 Xenopus (Silurana) tropicalis
100223655 Taeniopygia guttata
3800584 Plasmodium yoelii yoelii 17XNL
416071 Gallus gallus
495983 Xenopus laevis
700974 Macaca mulatta
747260 Pan troglodytes
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