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Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Additionally we are shipping GPRC6A Kits (5) and and many more products for this protein.
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Human Polyclonal GPRC6A Primary Antibody for IHC (p) - ABIN270833
Harno, Edwards, Geraghty, Ward, Dodd, Dauban, Faure, Ruat, Weston: Evidence for the presence of GPRC6A receptors in rat mesenteric arteries. in Cell calcium 2008
Show all 2 Pubmed References
he nonrare polymorphism rs2274911 in the GPRC6A gene was associated with insulin (show INS Antibodies) resistance features, independently of the metabolic phenotype and osteocalcin (show BGLAP Antibodies) levels.
Genetic Variations in the Human G Protein-coupled Receptor (show ADRA1A Antibodies) Class C, Group 6, Member A (show CXCL14 Antibodies) (GPRC6A) Control Cell Surface Expression and Function
Osteocalcin (show BGLAP Antibodies) and Sex Hormone Binding Globulin (show SHBG Antibodies) Compete on a Specific Binding Site of GPRC6A.
results suggest that G protein-coupled receptor (show ADRA1A Antibodies) class C group 6 member A (show CXCL14 Antibodies)(GPRC6A) inactivation or sub-function contributes to reduced exposure to androgens, leading to cryptorchidism during fetal life and/or low sperm production in adulthood
association of the THADA, FOXP4 (show FOXP4 Antibodies), GPRC6A/RFX6 (show RFX6 Antibodies) and 8q24 genes with prostate cancer in Asian populations.
The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 (show MAPK1/3 Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway in arginine-mediated fibroblast survival.
Duox1 (show DUOX1 Antibodies) activity is stimulated by testosterone through GPRC6A in skin keratinocytes
The F464Y substitution in GPRC6A may be a cause of primary testicular failure.
Extracellular Ca2 (show CA2 Antibodies)+ activates the NLRP3 (show NLRP3 Antibodies) inflammasome via CaSR (show CASR Antibodies) and GPRC6A.
the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 (show GCG Antibodies) secretion
GPCR6A activation by Alum leads to the initiation of innate inflammatory responses whereas it is an important signal for the limitation of adaptive immune responses induced by Alum, partially explained by B cell IL-10 (show IL10 Antibodies).
the loss of osteocalcin (show BGLAP Antibodies)/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis
the GPRC6A receptor is involved in regulating exercise behaviour
Activation of GPRC6A by L-arginine (show GATM Antibodies) did not stimulate insulin (show INS Antibodies) secretion.
GPRC6A is a novel molecular target for regulating prostate growth and cancer progression.
These findings suggest that GPRC6A is a candidate for mediating the response to Ocn in the bone-pancreas endocrine loop regulating insulin (show INS Antibodies) signaling.
GPRC6A is functionally important in regulating non-genomic effects of androgens in multiple tissues.
Osteoblasts and BMSCs derived from GPRC6A(-/-) mice exhibited an attenuated response to extracellular calcium-stimulated extracellular signal-related kinase (ERK (show EPHB2 Antibodies)) activation, diminished alkaline phosphatase expression, and impaired mineralization ex vivo
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005
G protein-coupled receptor, family C, group 6, member A
, G-protein coupled receptor family C group 6 member A-like
, G-protein coupled receptor GPCR33
, G-protein coupled receptor family C group 6 member A
, predicted with SOSUI analysis
, seven transmembrane helix receptor