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Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 Proteins (GGA3)

GGA3 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Additionally we are shipping GGA3 Antibodies (56) and GGA3 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GGA3 260302 Q8BMI3
Rat GGA3 GGA3 360658  
GGA3 23163 Q9NZ52
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Top GGA3 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GGA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) Interaction Partners

Mouse (Murine) Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) interaction partners

  1. depletion of GGA1 (show GGA1 Proteins) and GGA3 engender a rapid and robust elevation of BACE1 (show BACE Proteins) in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 (show BACE Proteins) solely depends on GGA3 levels in the subacute phase of injury

  2. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery

Human Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) interaction partners

  1. This work identifies GGA3 as a key player in a novel DXXLL-mediated endosomal sorting machinery that targets TrkA (show NTRK1 Proteins) to the plasma membrane, where it prolongs the activation of Akt (show AKT1 Proteins) signaling and survival responses.

  2. role of GGA3 in the cell surface export of alpha2B (show ADRA2B Proteins)-adrenergic receptor

  3. These data indicate that clathrin is required for the function of AP-1 (show FOSB Proteins)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  4. GGA3 is involved in the cellular processes relevant for Alzheimer's disease pathogenesis.

  5. Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP (show APP Proteins).

  6. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery

  7. structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors

  8. These results indicate that GGA3-S is predominantly expressed in human tissues except the brain and in cell lines.

  9. RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor (show IGF2R Proteins) and internalized epidermal growth factor (EGF (show EGF Proteins)) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF (show EGF Proteins).

  10. found that the human GGA3 protein GAT domain contains two ubiquitin binding motifs that bind to the same surface of ubiquitin

GGA3 Protein Profile

Protein Summary

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.

Gene names and symbols associated with GGA3

  • golgi associated, gamma adaptin ear containing, ARF binding protein 3 (Gga3)
  • golgi-associated, gamma adaptin ear containing, ARF binding protein 3 (GGA3)
  • C230037M19Rik protein
  • mKIAA0154 protein

Protein level used designations for GGA3

ADP-ribosylation factor-binding protein GGA3 , golgi-localized, gamma ear-containing, ARF-binding protein 3 , Golgi-localized, gamma ear-containing, ARF-binding protein 3 , golgi associated, gamma adaptin ear containing, ARF binding protein 3 , ADP-ribosylation factor binding protein 3

GENE ID SPECIES
260302 Mus musculus
360658 Rattus norvegicus
23163 Homo sapiens
483310 Canis lupus familiaris
454877 Pan troglodytes
100172741 Pongo abelii
100525777 Sus scrofa
510539 Bos taurus
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