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Growth Differentiation Factor 9 Proteins (GDF9)

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Additionally we are shipping GDF9 Antibodies (123) and GDF9 Kits (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GDF9 2661 O60383
GDF9 14566 Q07105
GDF9 59304  
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Top GDF9 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$682.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$795.30
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,284.33
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,284.33
Details

GDF9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,
Rat (Rattus)

Top referenced GDF9 Proteins

  1. Human GDF9 Protein expressed in Wheat germ - ABIN1354976 : Lin, Li, Xu, Wang, Namgoong, Cui, Kim: Effects of growth differentiation factor 9 and bone morphogenetic protein 15 on the in vitro maturation of porcine oocytes. in Reproduction in domestic animals = Zuchthygiene 2014 (PubMed)

More Proteins for Growth Differentiation Factor 9 (GDF9) Interaction Partners

Zebrafish Growth Differentiation Factor 9 (GDF9) interaction partners

  1. GDF9 expression was highest in primary growth follicles and gradually decreased during follicular development. Lowest level was found in fully grown follicles. It was maintained through fertilization and early embryonic development until gastrulation.

Human Growth Differentiation Factor 9 (GDF9) interaction partners

  1. GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 (show BMP15 Proteins) rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population.

  2. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15 (show BMP15 Proteins). Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.

  3. GDF-9 and GDF-15 (show GDF15 Proteins) levels may influence bone parameters in polycystic ovary syndrome

  4. GDF9 and BMP15 (show BMP15 Proteins) expression is reduced in primordial, primary, and secondary follicles in ovarian tissues of PCOS patients.

  5. The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity.

  6. Eleven unique copy number changes are identified in a total of 11 patients, including a tandem duplication of 475 bp, containing part of the GDF9 gene promoter region.

  7. Data suggest up-regulation of mRNA for GDF9 and BMP15 (bone morphogenetic protein 15 (show BMP15 Proteins)) in cumulus granulosa cells serves as biomarker for oocyte maturation, fertilization, embryo quality, and pregnancy in couples undergoing ICSI for male infertility.

  8. These results suggest that COCs cultured with recombinant GDF9 in oocyte maturation medium improve oocyte developmental competence and subsequent developmental competence of cloned embryo in cattle.

  9. Reduced expression of growth and differentiation factor-9 is associated with aggressive behaviour of clear-cell renal cell carcinoma (show MOK Proteins).

  10. Oocyte-derived GDF9 does not alter gap junction intercellular communication activity between human granulosa cells.

Mouse (Murine) Growth Differentiation Factor 9 (GDF9) interaction partners

  1. In organogenesis of the ovary, production of Dhh (show DHH Proteins)/Ihh (show IHH Proteins) in granulosa cells requires growth differentiation factor 9 from the oocyte.

  2. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15 (show BMP15 Proteins). Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.

  3. The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity during heterodimer formation.

  4. modified oocyte glycoproteins alter GDF9:BMP15 (show BMP15 Proteins) expression modifying follicle development resulting in the generation of more follicles

  5. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha (show INHA Proteins)(-/-) mouse model.

  6. Embryo vitrification has no effect on ovarian morphology or expression of GDF9.

  7. The results show that chronic unpredictable stress suppresses GDF9 expression.

  8. show that purified mature regions of GDF9 and BMP15 (show BMP15 Proteins) synergistically interact in a specific manner which is not dependent on the presence of a pro-region.

  9. GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals

  10. Data indicate that GDF-9 is absent in follicles of obese anovulatory/PCOS ovaries; upon treatment by heterotopic transplantation of gonadal adipose tissue from lean mice, expression of GDF-9 and ovulation appear to resume.

Pig (Porcine) Growth Differentiation Factor 9 (GDF9) interaction partners

  1. These results show that GDF9 and BMP15 (show BMP15 Proteins) participate in cumulus expansion and that they stimulate MPF (show MSLN Proteins) and MAPK (show MAPK1 Proteins) activities in porcine oocytes during in vitro maturation.

  2. Report temporal regulation of GDF9 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

  3. injection of porcine GDF-9 gene resulted in an increase in the number of primary, secondary and tertiary ovarian follicles

  4. Porcine GDF9 gene was found to be highly expressed in immature oocytes and declined slowly during the oocyte maturation process

  5. GDF9 may be not associated with pig litter size in extensive populations as per the studies of allele distributions of the four polymorphisms and pilot association in four breeds.

Cow (Bovine) Growth Differentiation Factor 9 (GDF9) interaction partners

  1. Immunization against GDF9 and BMP15 (show BMP15 Proteins), alone or together, altered follicular development and ovulation rate in cattle.

  2. GDF9 expression in the oocytes of calf ovaries was significantly higher than in those of the adult ovaries

  3. GDF-9 mediates its effect through the pathway commonly activated by TGF beta and activin, but not that activated by many BMPs

  4. Maternal GDF9 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation.

  5. Oocyte- and granulosa cell-derived GDF9 may simultaneously promote theca cell proliferation and prevent premature differentiation of the theca interna during early follicle development.

Goat Growth Differentiation Factor 9 (GDF9) interaction partners

  1. Expression of BMP15 (show BMP15 Proteins) (p < 0.01) and GDF9 (p < 0.05) mRNAs was more abundant in the small than the large antral follicles of Black Bengal goat.

  2. GNRH1 (show GNRH1 Proteins) and GDF9 genes could serve as genetic markers for litter size in goat breeding.

  3. Mutation A959C in GDF9 gene has been associated with prolificacy.

  4. Expression levels of follicular GDF9 and total ovarian BMPR1B (show BMPR1B Proteins) were not different between the Lezhi black goat and the Tibetan goat.

  5. These results provide further evidence that the GDF9 gene may be significantly correlated with high prolificacy in goats.

GDF9 Protein Profile

Protein Summary

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily.

Gene names and symbols associated with GDF9

  • growth differentiation factor 9 (GDF9)
  • growth differentiation factor 9 (gdf9)
  • growth differentiation factor 9 (Gdf9)
  • Gdf-9 protein
  • zgc:123030 protein

Protein level used designations for GDF9

growth and differentiation factor 9 , growth/differentiation factor 9 , GDF-9 , growth differentiation factor-9

GENE ID SPECIES
100072822 Equus caballus
497643 Danio rerio
2661 Homo sapiens
14566 Mus musculus
59304 Rattus norvegicus
404533 Gallus gallus
100313495 Canis lupus familiaris
414285 Sus scrofa
282574 Bos taurus
100328727 Oryctolagus cuniculus
100735066 Cavia porcellus
100860859 Capra hircus
100217402 Ovis aries
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