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Growth Factor Independent 1B Transcription Repressor Proteins (GFI1B)

Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Additionally we are shipping GFI1B Antibodies (31) and GFI1B Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GFI1B 14582 O70237
GFI1B 8328 Q5VTD9
Rat GFI1B GFI1B 311832  
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Top GFI1B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,911.33
Details

GFI1B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Growth Factor Independent 1B Transcription Repressor (GFI1B) Interaction Partners

Mouse (Murine) Growth Factor Independent 1B Transcription Repressor (GFI1B) interaction partners

  1. these results identify Rgs18 (show RGS18 Proteins) as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.

  2. Gfi1b is a regulator of embryonic globin expression and embryonic and adult erythroid maturation.

  3. results, supported by evidence from mouse models, identify GFI1 (show ZNF163 Proteins) and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer

  4. Gfi1 (show ZNF163 Proteins) and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro.

  5. GFI1B, EVI5, MYB (show MYB Proteins) are additional mouse genes that cooperate with the human BCL6 (show BCL6 Proteins) gene to promote the development of lymphomas.

  6. There is direct yet differential regulation of meis1 (show MEIS1 Proteins) transcription by Gfi1b in distinct hematopoietic lineages.

  7. GFI1 (show ZNF163 Proteins) and GFI1B are able to trigger, in the absence of RUNX1 (show RUNX1 Proteins), the down-regulation of endothelial markers and the formation of round cells, a morphologic change characteristic of endothelial to hematopoietic transition.

  8. Gfi family members are essential for normal B cell development and play an important role in modulating expression of the V(D)J recombinase (show RAG1 Proteins).

  9. The transcription factor Gfi1b defines the brush cell lineage and its progenitors, and with Hes1 and Atoh1 (show ATOH1 Proteins) forms a fate-determining Notch (show NOTCH1 Proteins) signaling driven ternary switch in the developing intestinal epithelium.

  10. adult mice conditionally deficient for Gfi1b show a significant expansion of functional HSCs in the bone marrow and blood

Human Growth Factor Independent 1B Transcription Repressor (GFI1B) interaction partners

  1. SPI1 (show SPI1 Proteins)-GFI1B transcriptional network is an important regulatory axis in acute myeloid leukemia (show BCL11A Proteins) as well as in the development of erythroid versus myelomonocytic cell fate

  2. Gfi1b functions as a transcriptional repressor by recruiting histone-modifying enzymes to promoters and enhancers of target genes. Mutations are associated with certain bleeding disorders. Review.

  3. a mutation in GFI1B causes a platelet disorder; GFI1B has a role a critical regulator of platelet shape, number, and function

  4. results, supported by evidence from mouse models, identify GFI1 (show ZNF163 Proteins) and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer

  5. TAL1 (show TAL1 Proteins) is involved in regulating H3K27me3 variations in collaboration with GFI1B

  6. Silencing of both BCR-ABL (show ABL1 Proteins) siRNA and GFI1B siRNA is associated with an additive antileukemic effect against K562 cells.

  7. Our studies show that GFI1B, in addition to being causally related to the gray platelet syndrome, is key to megakaryocyte and platelet development.

  8. Gfi-1B p32, a Gfi-1B isoform, is essential for erythroid differentiation

  9. GFI1B regulatory elements behave as activators and repressors, consistent with a model in which GFI1B binds to its own promoter and to the conserved non-coding elements as its levels rise.

  10. Results reveal the presence of different protein complexes, including GATA-1 (show GATA1 Proteins) and Oct-1 (show POU2F1 Proteins), involved in Gfi1b regulation.

GFI1B Protein Profile

Protein Summary

Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Gene names and symbols associated with GFI1B

  • growth factor independent 1B transcription repressor (GFI1B)
  • growth factor independent 1B transcription repressor (gfi1b)
  • Zinc finger protein Gfi-1b (gfi1b)
  • growth factor independent 1B (Gfi1b)
  • growth factor independent 1B transcription repressor (Gfi1b)
  • GFI protein
  • Gfi-1B protein
  • GFI1B protein
  • MGC80648 protein
  • znf544 protein

Protein level used designations for GFI1B

zinc finger protein Gfi-1b , zinc finger protein 544 , growth factor independent protein 1B , growth factor independent 1B transcription repressor , growth factor independent 1B (potential regulator of CDKN1A, translocated in CML) , Zinc finger protein Gfi-1b , potential regulator of CDKN1A translocated in CML , growth factor independent 1B-like protein , growth factor-independent protein 1B

GENE ID SPECIES
100514698 Sus scrofa
446835 Xenopus laevis
473080 Pan troglodytes
100195098 Salmo salar
14582 Mus musculus
8328 Homo sapiens
491281 Canis lupus familiaris
537773 Bos taurus
311832 Rattus norvegicus
395977 Gallus gallus
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