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Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Additionally we are shipping GFI1B Antibodies (30) and GFI1B Kits (10) and many more products for this protein.
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these results identify Rgs18 (show RGS18 Proteins) as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.
Gfi1b is a regulator of embryonic globin expression and embryonic and adult erythroid maturation.
results, supported by evidence from mouse models, identify GFI1 (show ZNF163 Proteins) and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene (show RAB1A Proteins) activation in a childhood cancer
Gfi1 (show ZNF163 Proteins) and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro.
GFI1B, EVI5, MYB (show MYB Proteins) are additional mouse genes that cooperate with the human BCL6 (show BCL6 Proteins) gene to promote the development of lymphomas.
There is direct yet differential regulation of meis1 (show MEIS1 Proteins) transcription by Gfi1b in distinct hematopoietic lineages.
GFI1 (show ZNF163 Proteins) and GFI1B are able to trigger, in the absence of RUNX1 (show RUNX1 Proteins), the down-regulation of endothelial markers and the formation of round cells, a morphologic change characteristic of endothelial to hematopoietic transition.
Gfi family members are essential for normal B cell development and play an important role in modulating expression of the V(D)J recombinase (show RAG1 Proteins).
The transcription factor Gfi1b defines the brush cell lineage and its progenitors, and with Hes1 and Atoh1 (show ATOH1 Proteins) forms a fate-determining Notch (show NOTCH1 Proteins) signaling driven ternary switch in the developing intestinal epithelium.
adult mice conditionally deficient for Gfi1b show a significant expansion of functional HSCs in the bone marrow and blood
SPI1 (show SPI1 Proteins)-GFI1B transcriptional network is an important regulatory axis in acute myeloid leukemia (show BCL11A Proteins) as well as in the development of erythroid versus myelomonocytic cell fate
Gfi1b functions as a transcriptional repressor by recruiting histone-modifying enzymes to promoters and enhancers of target genes. Mutations are associated with certain bleeding disorders. Review.
a mutation in GFI1B causes a platelet disorder; GFI1B has a role a critical regulator of platelet shape, number, and function
TAL1 (show TAL1 Proteins) is involved in regulating H3K27me3 variations in collaboration with GFI1B
Silencing of both BCR-ABL (show ABL1 Proteins) siRNA and GFI1B siRNA is associated with an additive antileukemic effect against K562 cells.
Our studies show that GFI1B, in addition to being causally related to the gray platelet syndrome, is key to megakaryocyte and platelet development.
Gfi-1B p32, a Gfi-1B isoform, is essential for erythroid differentiation
GFI1B regulatory elements behave as activators and repressors, consistent with a model in which GFI1B binds to its own promoter and to the conserved non-coding elements as its levels rise.
Results reveal the presence of different protein complexes, including GATA-1 (show GATA1 Proteins) and Oct-1 (show POU2F1 Proteins), involved in Gfi1b regulation.
Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
zinc finger protein Gfi-1b
, zinc finger protein 544
, growth factor independent protein 1B
, growth factor independent 1B transcription repressor
, growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)
, Zinc finger protein Gfi-1b
, potential regulator of CDKN1A translocated in CML
, growth factor independent 1B-like protein
, growth factor-independent protein 1B