anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Antibodies

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Additionally we are shipping HUWE1 Kits (25) and HUWE1 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HUWE1 10075 Q7Z6Z7
HUWE1 59026 Q7TMY8
HUWE1 501546  
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Top anti-HUWE1 Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, PLA, WB Detection of Human Ureb1/Lasu1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 1/4 of IP loaded) from 293T cells. Antibodies: ABIN152075 used at 1 mcg/ml for WB (A and B) and at 3 mcg/mg lysate for IP (B). Ureb1/Lasu1 was less efficiently immunoprecipitated by another Ureb1/Lasu1 antibody, which is an affinity purified rabbit antibody to a downstream epitope from Ureb1/Lasu1. Detection: Chemiluminescence with an exposure time of 10 seconds. Immunohistochemistry-Paraffin: HUWE1 Antibody [ABIN152075] - FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit antiLasu1/Ureb1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB Counterstain: IHC Hematoxylin (blue). 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 10 to 12 Days
$375.38
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.45 KDa) . 50 μL Log in to see 11 to 12 Days
$298.57
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with HUWE1 antibody ABIN213933 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with HUWE1 antibody ABIN213933 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Goat Un-conjugated ELISA   0.1 mg Log in to see 7 to 9 Days
$317.63
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: HUWE1 Antibody [NBP1-76795] - Daudi cells with HUWE1 antibody at 5 ug/ml. Western Blot: HUWE1 Antibody [NBP1-76795] - Daudi cell lysate with HUWE1 antibody at 1 ug/ml. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$466.62
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

HUWE1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HUWE1 Antibodies

  1. Human Polyclonal HUWE1 Primary Antibody for ICC, IF - ABIN152075 : Hall, Kow, Nevis, Lu, Luce, Zhong, Cook: Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. in Molecular biology of the cell 2007 (PubMed)
    Show all 14 references for 152075

  2. Human Polyclonal HUWE1 Primary Antibody for ICC, ELISA - ABIN1001821 : Gallagher, Kefford, Rizos: The ARF tumour suppressor. in The international journal of biochemistry & cell biology 2006 (PubMed)
    Show all 4 references for 1001821

  3. Human Polyclonal HUWE1 Primary Antibody for ELISA - ABIN4222056 : Stankiewicz, Livingstone, Mohseni, Mosser: Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. in Cell death and differentiation 2009 (PubMed)

  4. Human Polyclonal HUWE1 Primary Antibody for ELISA, WB - ABIN564354 : Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. in Molecular & cellular proteomics : MCP 2014 (PubMed)

More Antibodies against HUWE1 Interaction Partners

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.

  2. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.

  3. The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (show CSNK1A1 Antibodies)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (show ATOH1 Antibodies) ubiquitylation and subsequent degradation.

  4. Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  5. Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.

  6. We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.

  7. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  8. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  9. TNF (show TNF Antibodies) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (show CDKN2A Antibodies). Inhibition of Mule phosphorylation by silencing Syk (show SYK Antibodies) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Antibodies)-induced JNK (show MAPK8 Antibodies) activation and cell death.

  10. HUWE1 and NEDD4-1 (show NEDD4 Antibodies) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (show ABCG1 Antibodies) and ABCG4 (show ABCG4 Antibodies) protein levels and cellular cholesterol export activity

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. Taken together, these data identify HUWE1 as a bona fide tumour suppressor gene in the intestinal epithelium and suggest a potential vulnerability of HUWE1-mutated tumours to DNA-damaging agents and inhibitors of anti-apoptotic proteins.

  2. Mule also regulates protein levels of the receptor tyrosine kinase (show ERBB3 Antibodies) EphB3 (show EPHB3 Antibodies) by targeting it for proteasomal and lysosomal degradation.

  3. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  4. TNF (show TNF Antibodies) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (show CDKN2A Antibodies). Inhibition of Mule phosphorylation by silencing Syk (show SYK Antibodies) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Antibodies)-induced JNK (show MAPK8 Antibodies) activation and cell death.

  5. expression level of miR (show MLXIP Antibodies)-98, which can regulate Caspase-3 (show CASP3 Antibodies), was significantly decreased. Huwe1, the host gene of miR (show MLXIP Antibodies)-98, was positively associated with miR (show MLXIP Antibodies)-98 expression after Silica NP exposure

  6. Thus, modulating the levels of both Huwe1 and USP10 (show USP10 Antibodies) appears to fine-tune the requisite degradation of TBP (show TBP Antibodies) during myogenesis.

  7. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  8. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  9. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (show MYC Antibodies)/Miz1 (show PIAS2 Antibodies) complexes that mediates p21 (show D4S234E Antibodies) and p15 (show CDKN2B Antibodies) down-regulation

  10. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

Cow (Bovine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. E3Histone is therefore a HECT domain E3 that likely plays an important role in the chromatin condensation

HUWE1 Antigen Profile

Protein Summary

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) antibody
  • HECT, UBA and WWE domain containing 1 (Huwe1) antibody
  • HECT, UBA and WWE domain containing 1 (HUWE1) antibody
  • HECT, UBA and WWE domain containing 1 (huwe1) antibody
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1) antibody
  • 5430439H10Rik antibody
  • arf-bp1 antibody
  • AU041296 antibody
  • C80292 antibody
  • C430014N20Rik antibody
  • Gm1718 antibody
  • hecth9 antibody
  • hspc272 antibody
  • Huwe1 antibody
  • ib772 antibody
  • lasu1 antibody
  • mule antibody
  • si:dkey-242a8.2 antibody
  • URE-B1 antibody
  • ureb1 antibody

Protein level used designations for HUWE1

ARF-binding protein 1 , BJ-HCC-24 tumor antigen , E3 ubiquitin-protein ligase HUWE1 , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , URE-binding protein 1 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1 , upstream regulatory element-binding protein 1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , upstream regulatory element binding protein 1 , HECT, UBA and WWE domain containing 1 , rp3-339a18.4 , e3 ubiquitin-protein ligase HUWE1-like

GENE ID SPECIES
10075 Homo sapiens
59026 Mus musculus
465650 Pan troglodytes
480931 Canis lupus familiaris
511826 Bos taurus
559439 Danio rerio
700136 Macaca mulatta
100060375 Equus caballus
100123214 Nasonia vitripennis
100126217 Xenopus (Silurana) tropicalis
100380641 Salmo salar
100483129 Ailuropoda melanoleuca
100563451 Anolis carolinensis
501546 Rattus norvegicus
Selected quality suppliers for anti-HUWE1 (HUWE1) Antibodies
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