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HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Additionally we are shipping HUWE1 Kits (9) and HUWE1 Proteins (2) and many more products for this protein.
Showing 10 out of 70 products:
Human Polyclonal HUWE1 Primary Antibody for ICC, IF - ABIN152075
Hall, Kow, Nevis, Lu, Luce, Zhong, Cook: Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. in Molecular biology of the cell 2007
Show all 13 references for ABIN152075
Human Polyclonal HUWE1 Primary Antibody for ICC, ELISA - ABIN1001821
Gallagher, Kefford, Rizos: The ARF tumour suppressor. in The international journal of biochemistry & cell biology 2006
Show all 4 references for ABIN1001821
Human Polyclonal HUWE1 Primary Antibody for EIA, IF - ABIN499331
Zhong, Gao, Du, Wang: Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. in Cell 2005
Show all 3 references for ABIN499331
Human Polyclonal HUWE1 Primary Antibody for ELISA - ABIN4222056
Stankiewicz, Livingstone, Mohseni, Mosser: Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. in Cell death and differentiation 2009
Human Polyclonal HUWE1 Primary Antibody for ELISA, WB - ABIN564354
Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. in Molecular & cellular proteomics : MCP 2014
this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.
TNF (show TNF Antibodies) activates Mule by inducing the dissociation of Mule from its inhibitor ARF (show CDKN2A Antibodies). Inhibition of Mule phosphorylation by silencing Syk (show SYK Antibodies) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Antibodies)-induced JNK (show MAPK8 Antibodies) activation and cell death.
expression level of miR (show MLXIP Antibodies)-98, which can regulate Caspase-3 (show CASP3 Antibodies), was significantly decreased. Huwe1, the host gene of miR (show MLXIP Antibodies)-98, was positively associated with miR (show MLXIP Antibodies)-98 expression after Silica NP exposure
Thus, modulating the levels of both Huwe1 and USP10 (show USP10 Antibodies) appears to fine-tune the requisite degradation of TBP (show TBP Antibodies) during myogenesis.
Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.
The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.
data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (show MYC Antibodies)/Miz1 (show PIAS2 Antibodies) complexes that mediates p21 (show D4S234E Antibodies) and p15 (show CDKN2B Antibodies) down-regulation
an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.
Mule regulates the ATM (show ATM Antibodies)-p53 (show TP53 Antibodies) axis to maintain B cell homeostasis under both steady-state and stress conditions.
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site.
Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.
We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.
Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.
miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.
HUWE1 and NEDD4-1 (show NEDD4 Antibodies) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (show ABCG1 Antibodies) and ABCG4 (show ABCG4 Antibodies) protein levels and cellular cholesterol export activity
Our findings highlight the importance of microduplications at Xp11.22 to ID, even in sporadic cases, and reveal new clinical and molecular insight into HUWE1 copy number gains.
we show that HUWE1 stimulates human lung cancer cell invasion through regulating TIAM1 (show TIAM1 Antibodies) stability. Finally, we demonstrate that HUWE1 and TIAM1 (show TIAM1 Antibodies) protein levels are inversely correlated in human lung carcinomas
Inhibition of HUWE1 stabilizes MIZ1 (show ZBTB17 Antibodies) and induces global accumulation of MIZ1 (show ZBTB17 Antibodies) on MYC (show MYC Antibodies)-bound target genes.
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.
E3 ubiquitin-protein ligase HUWE1
, HECT, UBA and WWE domain-containing protein 1
, Mcl-1 ubiquitin ligase
, URE-binding protein 1
, upstream regulatory element binding protein 1
, upstream regulatory element-binding protein 1
, ARF-binding protein 1
, BJ-HCC-24 tumor antigen
, HECT domain protein LASU1
, Mcl-1 ubiquitin ligase E3
, homologous to E6AP carboxyl terminus homologous protein 9
, large structure of UREB1