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HLA-E belongs to the HLA class I heavy chain paralogues. Additionally we are shipping HLA Class I Histocompatibility Antigen, alpha Chain E Antibodies (131) and HLA Class I Histocompatibility Antigen, alpha Chain E Kits (8) and many more products for this protein.
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HLA-E regulates NKG2C (show KLRC2 Proteins)+ natural killer cell function through presentation of a restricted peptide repertoire
HLA-E is capable of presenting a highly conserved peptide from HIV-1 capsid (AISPRTLNA) that is not recognized by NKG2A (show KLRC1 Proteins)/CD94 (show KLRD1 Proteins).
over-expression of HLA-E is associated with melanoma
Peptide-induced HLA-E expression in human PBMCs is dependent on peptide sequence and the HLA-E genotype.
this study suggests that minor histocompatibility antigens presented by HLA-E can represent an additional risk factor following lung transplantation.
These results indicate that E*01:01 is a novel protective genetic factor in EBV-associated cHL and support a role for HLA-E recognition on the control of EBV infection and lymphomagenesis.
HLA-E molecules traffic differently from the HLA-class I (show MICA Proteins) molecules and can play a fundamental role in the protection against intracellular pathogens and susceptibility to several diseases.
Functional differences and the immunological impact of HLA-E allelic variant Arg107Gly
increased risk of recurrent miscarriage in mothers carrying HLA-E*01:01 allele; meta-analysis
The results derived from this study imply that HLA-E polymorphisms may influence RA susceptibility and affect clinical outcome of anti-TNF (show TNF Proteins) therapy in female RA patients.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
HLA class I histocompatibility antigen, E alpha chain
, HLA class I histocompatibility antigen, alpha chain E
, MHC HLA-E alpha-1
, MHC HLA-E alpha-2.1
, MHC class I antigen E
, lymphocyte antigen