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anti-Hairy and Enhancer of Split 6 (Drosophila) (HES6) Antibodies

HES6 encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Additionally we are shipping Hairy and Enhancer of Split 6 (Drosophila) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HES6 55927 Q9JHE6
HES6 55502 Q96HZ4
HES6 316626  
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Top anti-Hairy and Enhancer of Split 6 (Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-HES6  Antibody Titration: 1.25 µg/mL  Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of HES6 Antibody (N-term) in MCF-7 cell line lysates (35ug/lane). HES6 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells, using HES6 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of HES6 Antibody (N-term) (ABIN653462) in MCF-7 cell line lysates (35 µg/lane). HES6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Hes6 AntibodyTitration: 1.0 µg/mL  Positive Control: Mouse Stomach 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of HES6 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of HES6 expression in HepG2 (A), HeLa (B), MCF7 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry analysis of HES-6 antibody in paraffin-embedded human brain tissue. Western blot analysis of HES-6 antibody  in extracts from HeLa cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

HES6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human , ,
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Rat (Rattus)


Top referenced anti-Hairy and Enhancer of Split 6 (Drosophila) Antibodies

  1. Human Polyclonal HES6 Primary Antibody for EIA, WB - ABIN952723 : Glubb, Joyce, Kennedy: Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. in Neuroscience letters 2009 (PubMed)
    Show all 4 references for ABIN952723

  2. Human Polyclonal HES6 Primary Antibody for IHC, WB - ABIN2777651 : Kang, Seol, Kim: The conserved WRPW motif of Hes6 mediates proteasomal degradation. in Biochemical and biophysical research communications 2005 (PubMed)

  3. Human Polyclonal HES6 Primary Antibody for WB - ABIN653462 : Scheffer, Sage, Corey, Pingault: Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. in FEBS letters 2007 (PubMed)

  4. Human Polyclonal HES6 Primary Antibody for ELISA, WB - ABIN1534068 : Bae, Bessho, Hojo, Kageyama: The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. in Development (Cambridge, England) 2000 (PubMed)

More Antibodies against Hairy and Enhancer of Split 6 (Drosophila) Interaction Partners

Zebrafish Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. the PT enhancer with the 3'UTR (show UTS2R Antibodies) of hes6 responded to the inhibition of retinoic acid synthesis and fibroblast growth factor signaling in a manner similar to endogenous hes6.

  2. hes6, the clock gene that does not oscillate, responds to negative feedback

  3. Data define a network of Her/Hes (show ATCAY Antibodies) dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.

  4. Forms specific heterodimers with her1 (show EGFR Antibodies), which may directly be required for regulating further target genes.

Mouse (Murine) Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.

  2. Hes6 physically and functionally interacts with RelA (show NFkBP65 Antibodies)-containing NF-kappaB (show NFKB1 Antibodies) complexes in cortical progenitor cells to control cortical neurogenesis.

  3. Hes6 regulates myogenic differentiation.

  4. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.

  5. Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation.

  6. ATOH1 (show ATOH1 Antibodies) activates HES6 transcription through binding to three clustered E boxes of its promoter

  7. Data reveal a role for Ascl1 (show ASCL1 Antibodies) in the regulation of Hes6, a proneurogenic factor that inhibits Notch (show NOTCH1 Antibodies) signaling to promote neural rather than glial differentiation

Human Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. prostate cancer-specific up-regulation of NOTCH3 (show NOTCH3 Antibodies) and HES6, is reported.

  2. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer.

  3. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1 (show E2F1 Antibodies).

  4. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility.

  5. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.

  6. Data suggest that Hes-6 is a potential oncogene (show RAB1A Antibodies) overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.

  7. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.

  8. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation.

  9. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin (show INS Antibodies) expression

  10. Increased expression of Notch3 (show NOTCH3 Antibodies), Jagged1 (show JAG1 Antibodies), Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells.

Hairy and Enhancer of Split 6 (Drosophila) (HES6) Antigen Profile

Protein Summary

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with HES6

  • hairy and enhancer of split 6 (Drosophila) (hes6) antibody
  • hairy and enhancer of split 6 (Hes6) antibody
  • hairy and enhancer of split 6 (Drosophila) (HES6) antibody
  • hairy and enhancer of split 6 (Drosophila) (Hes6) antibody
  • AI326893 antibody
  • bHLHb41 antibody
  • bHLHc23 antibody
  • her13.2 antibody
  • HES-6 antibody
  • YF-30 antibody

Protein level used designations for HES6

hairy and enhancer of split 6 , transcription cofactor HES-6 , C-HAIRY1 , class B basic helix-loop-helix protein 41

GENE ID SPECIES
373116 Danio rerio
55927 Mus musculus
55502 Homo sapiens
316626 Rattus norvegicus
531384 Bos taurus
Selected quality suppliers for anti-Hairy and Enhancer of Split 6 (Drosophila) (HES6) Antibodies
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