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HES6 encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Additionally we are shipping Hairy and Enhancer of Split 6 (Drosophila) Proteins (4) and many more products for this protein.
Showing 10 out of 61 products:
Human Polyclonal HES6 Primary Antibody for EIA, WB - ABIN952723
Glubb, Joyce, Kennedy: Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. in Neuroscience letters 2009
Show all 4 references for ABIN952723
Human Polyclonal HES6 Primary Antibody for IHC, WB - ABIN2777651
Kang, Seol, Kim: The conserved WRPW motif of Hes6 mediates proteasomal degradation. in Biochemical and biophysical research communications 2005
Human Polyclonal HES6 Primary Antibody for WB - ABIN653462
Scheffer, Sage, Corey, Pingault: Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. in FEBS letters 2007
Human Polyclonal HES6 Primary Antibody for ELISA, WB - ABIN1534068
Bae, Bessho, Hojo, Kageyama: The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. in Development (Cambridge, England) 2000
the PT enhancer with the 3'UTR (show UTS2R Antibodies) of hes6 responded to the inhibition of retinoic acid synthesis and fibroblast growth factor signaling in a manner similar to endogenous hes6.
hes6, the clock gene that does not oscillate, responds to negative feedback
Data define a network of Her/Hes (show ATCAY Antibodies) dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.
Forms specific heterodimers with her1 (show EGFR Antibodies), which may directly be required for regulating further target genes.
Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.
Hes6 physically and functionally interacts with RelA (show NFkBP65 Antibodies)-containing NF-kappaB (show NFKB1 Antibodies) complexes in cortical progenitor cells to control cortical neurogenesis.
Hes6 regulates myogenic differentiation.
Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.
Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation.
ATOH1 (show ATOH1 Antibodies) activates HES6 transcription through binding to three clustered E boxes of its promoter
Data reveal a role for Ascl1 (show ASCL1 Antibodies) in the regulation of Hes6, a proneurogenic factor that inhibits Notch (show NOTCH1 Antibodies) signaling to promote neural rather than glial differentiation
prostate cancer-specific up-regulation of NOTCH3 (show NOTCH3 Antibodies) and HES6, is reported.
HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer.
HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1 (show E2F1 Antibodies).
HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility.
HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.
Data suggest that Hes-6 is a potential oncogene (show RAB1A Antibodies) overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.
Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation.
Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin (show INS Antibodies) expression
Increased expression of Notch3 (show NOTCH3 Antibodies), Jagged1 (show JAG1 Antibodies), Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells.
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.
hairy and enhancer of split 6
, transcription cofactor HES-6
, class B basic helix-loop-helix protein 41