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Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Proteins (HSPA5)

The protein encoded by HSPA5 is a member of the heat shock protein 70 (HSP70) family. Additionally we are shipping GRP78 Antibodies (390) and GRP78 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSPA5 3309 P11021
HSPA5 14828 P20029
HSPA5 25617 P06761
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Top GRP78 Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 3 to 4 Days
$347.60
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$383.90
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,678.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,840.83
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$809.60
Details

HSPA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced GRP78 Proteins

  1. Human GRP78 Protein expressed in Escherichia coli (E. coli) - ABIN1686700 : Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998 (PubMed)
    Show all 10 references for ABIN1686700

  2. Human GRP78 Protein expressed in Escherichia coli (E. coli) - ABIN1686682 : Rechthand, Smith, Latker, Rapoport: Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus. in Journal of neuropathology and experimental neurology 1987 (PubMed)
    Show all 9 references for ABIN1686682

  3. Human GRP78 Protein expressed in Wheat germ - ABIN1307202 : Taylor, Gercel-Taylor, Parker: Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer. in Gynecologic oncology 2009 (PubMed)

More Proteins for Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) Interaction Partners

Xenopus laevis Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.

Human Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. The present data suggest that GRP78 plays a crucial role in the proliferation, migration, and invasion of pancreatic cancer cells and may be a suitable prognostic marker in pancreatic ductal adenocarcinoma.

  2. we report that GRP78 plays a crucial role in protecting renal cell carcinoma (show MOK Proteins) cells from hypoxic and hypoglycemic stress induced by anti-angiogenic therapy

  3. results provide new mechanistic insights into the understanding that deacetylation of HSPA5 by HDAC6 (show HDAC6 Proteins) facilitates GP78 (show AMFR Proteins)-mediated HSPA5 ubiquitination

  4. Data show that molecular chaperone (show HSP90AA1 Proteins) GRP78 and survivin (show BIRC5 Proteins) cooperatively conferred multi-drug resistance (MDR) by decreasing folate deficiency (FD)-induced reactive oxygen species (ROS (show ROS1 Proteins)) generation.

  5. GRP78 phosphorylation in sperm undergoes spatial reorganization during epididymal maturation.

  6. The protein chaperone GRP78 and the unfolded protein response were implicated as drivers of drug resistance. Preclinical studies show inhibiting GRP78 can reverse drug resistance. [review]

  7. stabilization of WASF3 (show WASF3 Proteins) function occurs through its interaction with ATAD3A (show ATAD3A Proteins) and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles

  8. The biological interaction of amelogenin (show AMELX Proteins) with Grp78 offers significant therapeutic potential for understanding the biological components and specific functions involved in the signal transduction of amelogenin (show AMELX Proteins)-induced periodontal tissue regeneration.

  9. STAT3 (show STAT3 Proteins) mediates GRP78-promoted breast cancer cell growth and migration.

  10. Inhibition of GRP78 functional activity disrupts autophagy and enhances the anti-myeloma effect of bortezomib.

Cow (Bovine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. This paper reports the localization of both GRP78 and HSP60 (show HSPD1 Proteins) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (show HSPD1 Proteins) in the sperm midpiece.

  2. BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death

Pig (Porcine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Over-expression of GRP78 enhances replication of Porcine Circovirus 2.

Mouse (Murine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. We show that chronic VPA treatment did not modify the ATXN3 (show ATXN3 Proteins) inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects

  2. these findings reveal a novel critical role of GRP78 in regulating ER stress-mediated apoptosis in cartilage development and the molecular mechanisms involved.

  3. ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src (show SRC Proteins) activation as well as induction of apoptosis

  4. BIP increased surface CD19 molecule (show CD19 Proteins) expression intensity and IL-10 (show IL10 Proteins)(+), PD-L1 (show CD274 Proteins)(hi) and FasL (show FASL Proteins)(hi) B cells induced by BIP share the CD19 (show CD19 Proteins)(hi) phenotype

  5. These studies demonstrate that BiP is critical for myelinating cell survival and contributes to the protective response of oligodendrocyte against inflammatory demyelination.

  6. These studies imply GRP78, but not GRP94 (show HSP90B1 Proteins), is required for mammary gland development.

  7. The expression of GRP78 and Bcl-2 (show BCL2 Proteins) was significantly higher in astrocytes pretreated with recombinant Shh (show SHH Proteins). These findings suggest that the expression of Shh (show SHH Proteins) may inhibit cell death by activating Bcl-2 (show BCL2 Proteins) through a GRP78-dependent pathway.

  8. A highly specific monoclonal antibody against GRP78 suppressed AKT (show AKT1 Proteins) activation and increased apoptosis in the cPten(f/f) tumors.

  9. AdGRP78 reduced expression of lipogenic genes and plasma triglycerides in the db/db (show LEPR Proteins) strain. Both G5 and G8 protein levels increased as did total biliary cholesterol

  10. Heterozygous mutant BiP mice revealed motor disabilities in aging.

Zebrafish Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.

GRP78 (HSPA5) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.

Gene names and symbols associated with HSPA5

  • 78 kDa glucose-regulated protein (CpipJ_CPIJ003550)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5)
  • 78 kDa glucose-regulated protein (grp78)
  • BiP/GRP78 (LOC100533358)
  • glucose-regulated protein 78 (BiP/grp78)
  • glucose-regulated protein 78 (Tc00.1047053506585.40)
  • glucose-regulated protein 78 (Tb11.02.5450)
  • glucose-regulated protein 78 (Tb11.02.5500)
  • glucose-regulated protein 78 (LmjF28.1200)
  • Hsp70 family ATPase KAR2 (KAR2)
  • glucose-regulated protein 78kDa (grp78)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (hspa5)
  • heat shock 70 kDa protein 5a (hspa5)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (Hspa5)
  • heat shock protein 5 (Hspa5)
  • heat shock protein 5 (hspa5)
  • AL022860 protein
  • AU019543 protein
  • baffled protein
  • Bip protein
  • cb865 protein
  • D2Wsu17e protein
  • D2Wsu141e protein
  • fb60h09 protein
  • fi36d04 protein
  • GRP-78 protein
  • Grp78 protein
  • Hsce70 protein
  • hspa5a protein
  • mBiP protein
  • MIF2 protein
  • SEZ-7 protein
  • Sez7 protein
  • wu:fb60h09 protein
  • wu:fi36d04 protein
  • zgc:55994 protein
  • zgc:77606 protein

Protein level used designations for HSPA5

78 kDa glucose-regulated protein , GRP-78 , heat shock 70 kDa protein 5 , Protein 1603 , 78 kDa glucose-regulated protein homolog , luminal-binding protein , glucose-regulated protein 78 , glucose-regulated protein 78kDa , heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) , GRP 78 , biP , heavy-chain binding protein BiP , immunoglobulin heavy chain-binding protein , endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 , glucose-regulated protein, 78kDa , XAP-1 antigen , glucose regulated protein, 78 kDa , heat shock 70kD protein 5 (glucose-regulated protein, 78kD) , heat shock 70kD protein 5 , heat shock 70kDa protein 5 (glucose-regulated protein) , steroidogenesis-activator polypeptide , bip

GENE ID SPECIES
6034961 Culex quinquefasciatus
100173944 Pongo abelii
100196613 Salmo salar
100533358 Aplysia californica
543957 Solanum lycopersicum
3540481 Trypanosoma cruzi strain CL Brener
3665880 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3665885 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5653331 Leishmania major strain Friedlin
853418 Saccharomyces cerevisiae S288c
100135840 Oncorhynchus mykiss
379756 Xenopus laevis
464733 Pan troglodytes
703193 Macaca mulatta
100015941 Monodelphis domestica
100599238 Nomascus leucogenys
397850 Xenopus laevis
3309 Homo sapiens
415113 Bos taurus
396487 Gallus gallus
100731108 Cavia porcellus
407060 Sus scrofa
480726 Canis lupus familiaris
780447 Ovis aries
14828 Mus musculus
25617 Rattus norvegicus
378848 Danio rerio
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