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IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and k. Additionally we are shipping Insulin-Degrading Enzyme Kits (39) and Insulin-Degrading Enzyme Proteins (12) and many more products for this protein.
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Human Polyclonal IDE Primary Antibody for IHC (p), WB - ABIN388241
Radulescu, Fischer, Stange, Schulze: Promoting scientific standards in Germany. in Science (New York, N.Y.) 2010
Show all 6 references for ABIN388241
Human Polyclonal IDE Primary Antibody for IHC (p), IHC - ABIN261102
Zhao, Xiang, Haroutunian, Buxbaum, Stetka, Pasinetti: Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. in Neurobiology of aging 2007
This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.
Findings show a key role of Pla2g3 (show PLA2G3 Antibodies) on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 (show PLA2G3 Antibodies) is involved in the initiation and/or progression of Alzheimer disease.
Abeta (show APP Antibodies) level reduction by CALHM1 (show CALHM1 Antibodies) could be explained by an increase in extracellular Abeta (show APP Antibodies) degradation by insulin-degrading enzyme.
Data suggest that protein restriction down-regulates expression of insulysin (insulin degrading enzyme) in liver and subsequently reduced insulin (show INS Antibodies) clearance.
IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta (show APP Antibodies) and RAGE (show AGER Antibodies), and higher serum cholesterol in male, Ldlr (show LDLR Antibodies)(-/-) mice.
The type 2 diabetes-associated gene ide is required for insulin (show INS Antibodies) secretion and suppression of alpha-synuclein (show SNCA Antibodies) levels in beta-cells.
this study identified an upstream promoter element which blocks the reverse transcription of mouse IDE.
Data show that in the absence of insulin-degrading enzyme (IDE), full-length calcitonin gene-related peptide (CGRP (show CALCA Antibodies)) levels are elevated in vivo.
role played by somatostatin (show SST Antibodies) in preventing Abeta (show APP Antibodies) accumulation by partially restoring IDE activity
These data suggest that NOS2 (show NOS2 Antibodies) upregulation impairs amyloid beta degradation through negative regulation of insulin degrading enzyme
the mechanistic and molecular features of IDE-26S proteasome (show Psmd4 Antibodies) interaction in a cell experimental model, is reported.
No significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with Alzheimer disease.
results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with late-onset Alzheimer disease susceptibility in the Xinjiang Han population
Cognitive impairment is more frequent among those exposed to the C allele of the rs2209972 SNP of the insulin degrading enzyme gene.
IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.
using combinational in silico investigations, study identified that pathogenic nonsynonymous mutations corresponding to p.I54F, p.P122T, p.T533R, p.P581A and p.Y609A have more potential role in structural and functional deviations of IDE activity
Our study provided evidence to IDE, PON1 (show PON1 Antibodies), WFS1 (show WFS1 Antibodies), POU2F1 (show POU2F1 Antibodies), IL1alpha (show IL1A Antibodies) and IL1beta (show IL1B Antibodies) associated with T2D in Pakistanis.
An upstream promoter element which blocks the antisense transcription of the human IDE promoter, was identified.
Both IDE and type 2 diabetes are associated with executive function levels in older adults
Conformational changes in IDE, including a swinging-door mechanism that permits the entry of short peptides into the catalytic chamber, governs the selective destruction of amyloidogenic peptides.
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
, insulin-degrading enzyme
, insulin-degrading enzyme-like
, insulin protease
, Abeta-degrading protease