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Lecithin-Cholesterol Acyltransferase Proteins (LCAT)

LCAT encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. Additionally we are shipping LCAT Antibodies (110) and LCAT Kits (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LCAT 16816 P16301
LCAT 24530  
LCAT 3931 P04180
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Top LCAT Proteins at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$3,035.21
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK293 Human DYKDDDDK Tag   1 mg Log in to see 3 to 4 Days
$6,240.93
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,449.33
Details
Yeast Aeromonas spp. His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,080.00
Details

LCAT Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,

Human , , , , ,
, ,

Top referenced LCAT Proteins

  1. Human LCAT Protein expressed in Escherichia coli (E. coli) - ABIN1098743 : Clay, Pyle, Rye, Barter: Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase. in The Journal of biological chemistry 2000 (PubMed)

More Proteins for Lecithin-Cholesterol Acyltransferase (LCAT) Interaction Partners

Mouse (Murine) Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. increased cholesterol esterification by LCAT is atheroprotective

  2. Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.

  3. DYRK1A (show DYRK1A Proteins) overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I (show APOA1 Proteins) levels.

  4. adrenal glucocorticoid function in LCAT knockout (KO) mice

  5. a novel function of apoA-IV (show APOA4 Proteins) in the biogenesis of discrete HDL (show HSD11B1 Proteins)-A-IV particles with the participation of ABCA1 (show ABCA1 Proteins) and LCAT

  6. Studies suggest that absence of lecithin cholesterol acyltransferase (LCAT) may protect against insulin (show INS Proteins) resistance, diabetes and obesity.

  7. Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (show SPTLC2 Proteins))+/- and sphingomyelin synthase 2 (Sms2 (show SGMS2 Proteins))-/- mice, but markedly lower in ApoE (show APOE Proteins)-/- and Ldlr (show LDLR Proteins)-/- mice.

  8. LCAT deficiency confers gender-specific protection against diet-induced obesity and insulin (show INS Proteins) resistance at least in part through regulation in UPR, white adipose tissue adipogenesis, and brown adipocyte partitioning

  9. Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E (show APOE Proteins) knockout background in association with a reduction in atherosclerosis

  10. LCAT contributes significantly to the cholesteryl ester (CE) fatty acid pool of apoB (show APOB Proteins) lipoprotein and is the only source of plasma long chain polyunsaturated CE in LDL receptor (show LDLR Proteins) and apoE (show APOE Proteins) knockout mice.

Human Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. Mapping the naturally occurring mutations onto the structure provides insight into how they may affect LCAT enzymatic activity.

  2. Report slightly reduction in LCAT that would probably reflect a delay in reverse cholesterol transport occurring in MetS.

  3. rs5923 polymorphism is not associated with low high-density lipoprotein cholesterol(HDL (show HSD11B1 Proteins)-C)levels in Iranian population

  4. increased cholesterol esterification by LCAT is atheroprotective

  5. The data indicate that this novel apoA-I (show APOA1 Proteins) missense is associated with markedly decreased levels of HDL (show HSD11B1 Proteins) cholesterol and very large alpha-1 HDL (show HSD11B1 Proteins), as well as decreased serum cellular cholesterol efflux and LCAT activity

  6. A robust all-atom model for LCAT generated by homology modeling

  7. This study investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of high-density lipoproteins.

  8. A synonymous H287H mutation in the coding region of exon 6 of the lecithin cholesterol acyltransferase gene was observed in an individual with HDLC levels of 75 mg/dl.

  9. Cosyntropin testing in an unselected subgroup of 8 ABCA1 (show ABCA1 Proteins) mutation carriers and 3 LCAT mutation carriers did not reveal differences between carriers and controls.

  10. The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits its toxic effect on cultured neurons.

Pig (Porcine) Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. The 1,434 bp mRNA sequence of porcine LCAT including the full coding region and encoding a protein of 472 amino acids, was obtained.

Rabbit Lecithin-Cholesterol Acyltransferase (LCAT) interaction partners

  1. LCAT cholesterol esterification is associated with the increase of ApoE (show APOE Proteins)/ApoA-I (show APOA1 Proteins) ratio during atherosclerosis progression in rabbit.

LCAT Protein Profile

Protein Summary

This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.

Gene names and symbols associated with LCAT

  • lecithin-cholesterol acyltransferase (LCAT)
  • lecithin-cholesterol acyltransferase (lcat)
  • lecithin cholesterol acyltransferase (Lcat)
  • lecithin-cholesterol acyltransferase (Lcat)
  • AI046659 protein
  • D8Wsu61e protein
  • LCAT protein
  • MGC82035 protein
  • MGC88964 protein

Protein level used designations for LCAT

lecithin-cholesterol acyltransferase , lecithin cholesterol acyltransferase , phosphatidylcholine-sterol acyltransferase , lecithin-cholesterol acyltransferase Lcat , phospholipid-cholesterol acyltransferase , Lecithin-cholesterol acyltransferase

GENE ID SPECIES
100053753 Equus caballus
114449 Danio rerio
447501 Xenopus laevis
448241 Xenopus (Silurana) tropicalis
743056 Pan troglodytes
100126664 Papio anubis
100389625 Callithrix jacchus
100469078 Ailuropoda melanoleuca
100528492 Ictalurus punctatus
16816 Mus musculus
24530 Rattus norvegicus
3931 Homo sapiens
479680 Canis lupus familiaris
100303723 Sus scrofa
510960 Bos taurus
100008978 Oryctolagus cuniculus
100727686 Cavia porcellus
396136 Gallus gallus
100302343 Ovis aries
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