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Left-Right Determination Factor 2 Proteins (LEFTY2)

LEFTY2 encodes a member of the TGF-beta family of proteins. Additionally we are shipping LEFTY2 Antibodies (58) and LEFTY2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LEFTY2 13590 Q64280
LEFTY2 7044 O00292
LEFTY2 289316  
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Top LEFTY2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

LEFTY2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced LEFTY2 Proteins

  1. Human LEFTY2 Protein expressed in Human Cells - ABIN2002430 : Meno, Saijoh, Fujii, Ikeda, Yokoyama, Yokoyama, Toyoda, Hamada: Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. in Nature 1996 (PubMed)
    Show all 4 references for ABIN2002430

More Proteins for Left-Right Determination Factor 2 (LEFTY2) Interaction Partners

Zebrafish Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  2. we find that Cyclops is specifically required for the maintenance of lefty1 (show LEFTY1 Proteins) and lefty2 transcription

  3. study reports that microRNA-430 (miR (show MYLIP Proteins)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (show TGFB1 Proteins) Nodal antagonist lefty

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. exogenous lefty1 (show LEFTY1 Proteins) administered to mice restored the endogenous expression levels of lefty1 (show LEFTY1 Proteins). The present study demonstrated that lefty1 (show LEFTY1 Proteins) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (show TGFB1 Proteins) signaling pathway

  2. Lefty-1 (show LEFTY1 Proteins) may prevent TGFB1 (show TGFB1 Proteins)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (show SMAD3 Proteins), JNK-3 (show MAPK10 Proteins), and BMP-5 (show BMP5 Proteins) signaling.

  3. The expression of lefty in RCC (show XRCC1 Proteins) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (show XRCC1 Proteins).

  4. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.

  5. Taken together, these results suggest that optimal expression of Lefty1 (show LEFTY1 Proteins) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

  6. Beta-catenin (show CTNNB1 Proteins) can recruit the H3K4me2/1 demethylase LSD1 (show KDM1A Proteins) to regulate the expression of the tumor suppressor Lefty1 (show LEFTY1 Proteins) in mouse embryonic stem cells.

  7. Lefty can antagonise TGF-beta1 (show TGFB1 Proteins) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

  8. Cerberus (show CER1 Proteins)-like and Lefty-1 (show LEFTY1 Proteins) function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak

  9. Regulated expression and spatial distribution of lefty in mouse endometrium confines its biological impact on tissues that undergo remodelling during estrous cycle and pregnancy.

  10. findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A (show PCSK5 Proteins)

Human Left-Right Determination Factor 2 (LEFTY2) interaction partners

  1. Lefty A may account for the tumor suppressive activity of human adult stem cells.

  2. Findings suggest that Lefty2 is negatively modulated by miR (show MLXIP Proteins)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  3. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression

  4. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells

  5. Addition of recombinant LEFTY-A to explants induced MMP-9 (show MMP9 Proteins) in most samples, a response prevented by ovarian steroids.

  6. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

LEFTY2 Protein Profile

Protein Summary

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with LEFTY2

  • lefty2 (lft2)
  • left-right determination factor 2 (LEFTY2)
  • left-right determination factor 2 (LOC100232580)
  • left right determination factor 1 (Lefty1)
  • left-right determination factor 2 (Lefty2)
  • Left-right determination factor 2 (Lefty2)
  • 6030463A22Rik protein
  • AI450052 protein
  • atv2 protein
  • AV214969 protein
  • cb720 protein
  • EBAF protein
  • Ebaf2 protein
  • fe38b03 protein
  • Lefta protein
  • Leftb protein
  • lefty protein
  • lefty-1 protein
  • LEFTY1 protein
  • LEFTYA protein
  • Stra3 protein
  • TGFB4 protein
  • wu:fe38b03 protein

Protein level used designations for LEFTY2

lefty , endometrial bleeding associated factor , left-right determination factor 1 , left-right determination factor 2 , left-right determination factor 2-like , TGF-beta-4 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , transforming growth factor beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , left-right determination factor B , left-right determination, factor A , protein lefty-B

GENE ID SPECIES
30146 Danio rerio
395529 Gallus gallus
457780 Pan troglodytes
490387 Canis lupus familiaris
699676 Macaca mulatta
100232580 Taeniopygia guttata
100435327 Pongo abelii
13590 Mus musculus
7044 Homo sapiens
320202 Mus musculus
289316 Rattus norvegicus
100337677 Sus scrofa
534018 Bos taurus
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