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LIPA encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). Additionally we are shipping Lipase A Proteins (11) and Lipase A Kits (9) and many more products for this protein.
Showing 10 out of 91 products:
Human Monoclonal Lipase A Primary Antibody for ELISA, WB - ABIN969484
Drebber, Andersen, Kasper, Lohse, Stolte, Dienes: Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: a case report. in World journal of gastroenterology : WJG 2005
Show all 2 Pubmed References
Human Monoclonal Lipase A Primary Antibody for ELISA, WB - ABIN966473
Boldrini, Devito, Biselli, Filocamo, Bosman: Wolman disease and cholesteryl ester storage disease diagnosed by histological and ultrastructural examination of intestinal and liver biopsy. in Pathology, research and practice 2004
Show all 2 Pubmed References
Human Polyclonal Lipase A Primary Antibody for ICC, IF - ABIN4331092
Lettieri Barbato, Tatulli, Aquilano, Ciriolo: FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment. in Cell death & disease 2013
Human Polyclonal Lipase A Primary Antibody for WB - ABIN517528
Roszell, Tao, Yu, Huang, Bates: Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung. in American journal of physiology. Lung cellular and molecular physiology 2012
Horse (Equine) Polyclonal Lipase A Primary Antibody for WB - ABIN611571
Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998
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Cholesterol esterase shows enantioselective inhibition for enantiomers of exo (show PHM Antibodies)- and endo-2-norbornyl-N-n-butylcarbamates.
Use CRISPR/Cas9 techniques to knockout LIPA in human induced pluripotent stem cells and differentiate them to macrophages.
LIPA associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
Study demonstrates that liver cirrhosis from any etiology is characterized by a significant reduction of LAL activity but no known c.894G>A SNP, which is likely on an acquired base and independent from the etiology of hepatic disease.
Coronary artery disease-associated coding variant rs1051338 causes reduced lysosomal LAL protein and activity because of increased LAL degradation.
results indicate that LAL is the major acid RE hydrolase and required for functional retinoid homeostasis.
These findings suggest a strong association between impaired LAL activity and Non-alcoholic fatty liver disease.
lyso (show LIPF Antibodies)somal acid lipase in hepatocytes is a critical metabolic enzyme in controlling neutral lipid metabolism
The observed loss-of-function phenotype in cholesteryl ester storage disease patients with the His295Tyr (H295Y) mutation in the LAL gene might arise from a combination of protein destabilization and the shift to a non-functional soluble aggregate.
Case Report: Mexican sisters with heterozygous mutations in exon 4: c.253C>A and c.294C>G resulting in lysosomal acid lipase deficiency.
To our knowledge, this is the first pediatric case of genetically and biopsy confirmed CESD without hepatomegaly, suggesting that this diagnosis can be easily missed.
The activity of lysosomal acid lipase was also decreased on treatment of macrophages with each modified LDL.
hLAL (show LIPF Antibodies) expression reduced tumor-promoting myeloid-derived suppressive cells in the liver of lal(-/-) mice
Results indicate that LAL has a critical role in regulating MDSCs' ability to directly stimulate cancer cell proliferation and overcome immune rejection of cancer metastasis in allogeneic mice through modulation of the mTOR (show FRAP1 Antibodies) pathway.
effect the loss of SOAT2 (show SOAT2 Antibodies) function has on tissue esterified cholesterol sequestration in lysosomal acid lipase-deficient mice in a model of cholesteryl ester storage disease
Lipolysis of triacylglycerol substrates by LAL is important for M2 macrophage activation, and its inhibition suppresses M2 activation.
LAL regulates endothelial cell function through interaction with myeloid-derived suppressor cells and modulation of the mTOR (show FRAP1 Antibodies) pathway, which provide mechanistic basis for targeting MDSCs or mTOR (show FRAP1 Antibodies) to rejuvenate EC functions in LAL deficiency-related diseases
These results indicate a crucial role of LAL-regulated mTOR signaling in the production and function of CD11b(+)Ly6G(+) cells.
SR-BI (show SCARB1 Antibodies)-delivered HDL (show HSD11B1 Antibodies)-CEs are hydrolyzed by hepatic CEH (show EPHX2 Antibodies) and utilized for bile acid synthesi
FoxO1 (show FOXO1 Antibodies) is upregulated by nutrient restriction (NR) in adipocytes and exerts the transcriptional control of lipid catabolism via the induction of lysosomal acid lipase
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)
, lysosomal acid lipase/cholesteryl ester hydrolase
, lipase A, lysosomal acid, cholesterol esterase
, lysosomal acid lipase/cholesteryl ester hydrolase-like
, acid cholesteryl ester hydrolase
, cholesterol ester hydrolase
, cholesteryl esterase
, lysosomal acid lipase
, sterol esterase
, Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25
, lysosomal acid lipase 1
, lysosomal acid lipase A
, pancreatic cholesterol esterase
, lipase A