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The protein encoded by LRP1 is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. Additionally we are shipping LRP1 Kits (28) and LRP1 Proteins (11) and many more products for this protein.
Showing 10 out of 163 products:
Hamster Monoclonal LRP1 Primary Antibody for FACS, IHC (fro) - ABIN125951
Basu, Binder, Ramalingam, Srivastava: CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. in Immunity 2001
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Human Monoclonal LRP1 Primary Antibody for FACS, IHC (fro) - ABIN125959
Coukos, Gåfvels, Wisel, Ruelaz, Strickland, Strauss, Coutifaris: Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts. in The American journal of pathology 1994
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Human Monoclonal LRP1 Primary Antibody for FACS, IHC (fro) - ABIN125958
Wolf, Lopes, VandenBerg, Gonias: Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. in The American journal of pathology 1992
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Human Polyclonal LRP1 Primary Antibody for EIA, IHC (p) - ABIN358150
Yu, Rux, Ma, Bdeir, Sachais: Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner. in Blood 2005
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Human Polyclonal LRP1 Primary Antibody for IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
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Human Monoclonal LRP1 Primary Antibody for FACS - ABIN119414
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
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Human Monoclonal LRP1 Primary Antibody for EIA, FACS - ABIN119413
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
Show all 2 references for ABIN119413
Human Polyclonal LRP1 Primary Antibody for ELISA, WB - ABIN1533132
Van Leuven, Stas, Hilliker, Lorent, Umans, Serneels, Overbergh, Torrekens, Moechars, De Strooper: Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. in Genomics 1995
Considering that LRP-1, by mediating the clearance of matrix metalloproteinases, is involved in the regulation of extracellular matrix remodeling and cell migration, we conclude that a decreased expression of LRP-1 could be involved with the increasing activity of MMPs shown in cancers.
These data suggest that the Rho/ROCK signaling pathway is involved in HIV-1 Tat (show TAT Antibodies)-mediated changes in occludin (show OCLN Antibodies), RAGE (show AGER Antibodies), and LRP1 in human cerebral microvascular endothelial cells cells.
Studies demonstrate a role for ADAM10 (show ADAM10 Antibodies) in the ectodomain shedding of LRP1 in the brain and the clearance of Abeta (show APP Antibodies) across the blood-brain barrier, which may provide a novel strategy for attenuating Abeta (show APP Antibodies) accumulation in the AD brain
Results provide evidence that TTR (show TTR Antibodies) acts as a carrier of Abeta (show APP Antibodies) at the blood-brain-barrier and liver, using LRP1.
Studies show the ability of LRP1 to promote endocytosis and deliver cell signaling suggesting multiple roles in tumorigenesis and tumor progression. In addition, LRP1 has dual effects on tumor cell invasion and migration. Moreover, LRP1 can be regulated via methylation of its CpG islands. [review]
Study demonstrated that 1,25(OH)2D3, the active form of vitamin D, plays an important role in increasing Abeta1-40 vectorial transport from the brain to blood and systemic clearance from peripheral circulation through increasing LRP1 levels both in vivo and in vitro, and reducing RAGE (show AGER Antibodies) level in the blood-brain barrier model in vitro
Circulating soluble LRP1 concentrations were associated with the occurrence of carotid atherosclerosis in a hypercholesterolemia population.
LRP1 as a pathogenic gene for autosomal recessive Keratosis pilaris atrophicans and keratosis pilaris
Suggest role for LRP1/PARP1 (show PARP1 Antibodies) signaling in endothelial cell proliferation and retinal neovascularization induced by hypoxia.
it was suggested that a cell surface-expressed beta-galactoside binding protein, galectin-8, was involved in factor V endocytosis.
A critical role was determined for astrocytic LRP1 in brain for clearing amyloid-beta accumulation.
Findings provide evidence for a central role of LRP1 in overall energy homeostasis, and specifically liver glucose and fatty acid metabolism. Its somatic inactivation in the liver predisposes to diet-induced insulin (show INS Antibodies) resistance with dyslipidemia and non-alcoholic hepatic steatosis.
extracellular (alpha) chain (show FCGRT Antibodies) of LRP1 mediates TGFbeta (show TGFB1 Antibodies)-induced enhancement of Wnt5a (show WNT5A Antibodies), which limits intracellular cholesterol accumulation.
conclude that LRP1, NFkappaB, and miR (show MLXIP Antibodies)-155 function as members of a previously unidentified system that has the potential to inhibit or sustain inflammation
This study demonstrated that bexarotene rescues aging-related declines of synaptic proteins through a neural LRP1-mediated pathway presumably by increasing apoE (show APOE Antibodies) levels and lipidation.
LRP1 interacts with beta1-integrin mediating integrin internalization and thus correlates with downstream signaling of beta1-integrin such as focal adhesion dynamics.
Selective deletion of Lrp1 in the brain endothelium of C57BL/6 mice strongly reduced brain efflux of injected [125I] Abeta (show APP Antibodies)(1-42).
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, low-density lipoprotein receptor-related protein 1