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MCF.2 Cell Line Derived Transforming Sequence Proteins (MCF2)

The oncogenic protein encoded by MCF2 is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Additionally we are shipping MCF2 Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCF2 4168 P10911
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Top MCF2 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days

MCF2 Proteins by Origin and Source

Origin Expressed in Conjugate

More Proteins for MCF.2 Cell Line Derived Transforming Sequence (MCF2) Interaction Partners

Human MCF.2 Cell Line Derived Transforming Sequence (MCF2) interaction partners

  1. Results support a role for Dbl oncogene (show RAB1A Proteins) in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF (show SLC2A4RG Proteins) deregulation in tumor onset and progression.

  2. Phosphoinositide 3-kinase C2beta regulates RhoA (show RHOA Proteins) and the actin cytoskeleton through an interaction with Dbl

  3. Dbl is regulated by hamartin (show TSC1 Proteins) through association with ezrin (show EZR Proteins).

  4. proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors

  5. data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene (show RAB1A Proteins) that show different tissue distributions and guanine nucleotide exchange factor (show RASGRF1 Proteins) specificities

  6. provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways

  7. These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 (show CDC42 Proteins) by Dbl is dependent on functional ERM (show ETV5 Proteins) proteins and is important for directional cell migration.

  8. Galphaq (show GNAQ Proteins) directly activates p63RhoGEF and Trio (show TRIO Proteins) via a conserved extension of the Dbl homology-associated pleckstrin (show PLEK Proteins) homology domain

  9. Nm23-H1 (show NME1 Proteins) can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 (show CDC42 Proteins) and possibly other Rho family members through interaction with Dbl-1

MCF2 Protein Profile

Protein Summary

The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.

Gene names and symbols associated with MCF2

  • MCF.2 cell line derived transforming sequence (MCF2)
  • ARHGEF21 protein
  • DBL protein

Protein level used designations for MCF2

Oncogene MCF2 (oncogene DBL) , proto-oncogene DBL , proto-oncogene MCF-2

4168 Homo sapiens
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