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Matrix Metallopeptidase 8 (Neutrophil Collagenase) Proteins (MMP8)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP8 Antibodies (144) and MMP8 Kits (86) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP8 17394 O70138
MMP8 63849 O88766
MMP8 4317 P22894
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Top MMP8 Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_CHO Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse Un-conjugated 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated 10 μg Log in to see 5 to 6 Days
$440.82
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Human Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$231.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

MMP8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,

Rat (Rattus) ,
,
Human , , , ,
,

Top referenced MMP8 Proteins

  1. Human MMP8 Protein expressed in HEK-293 - ABIN2666511 : Fang, Wen, Zhang, Lin, Moore, Wu, Ye, Xiao: An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo. in Cardiovascular research 2013 (PubMed)
    Show all 6 references for ABIN2666511

  2. Human MMP8 Protein expressed in Human Cells - ABIN2002436 : Belotti, Paganoni, Manenti, Garofalo, Marchini, Taraboletti, Giavazzi: Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. in Cancer research 2003 (PubMed)
    Show all 3 references for ABIN2002436

  3. Mouse (Murine) MMP8 Protein expressed in Human Cells - ABIN2007891 : Mira, Lacalle, Buesa, de Buitrago, Jiménez-Baranda, Gómez-Moutón, Martínez-A, Mañes: Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface. in Journal of cell science 2004 (PubMed)
    Show all 3 references for ABIN2007891

  4. Mouse (Murine) MMP8 Protein expressed in CHO Cells - ABIN2007889 : Ram, Sherer, Shoenfeld: Matrix metalloproteinase-9 and autoimmune diseases. in Journal of clinical immunology 2006 (PubMed)
    Show all 3 references for ABIN2007889

More Proteins for Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia.

  2. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.

  3. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.

  4. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin (show FMOD Proteins) and therefore increasing the bioavailability of TGF-beta (show TGFB1 Proteins).

  5. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL (show APOA Proteins)particles compared with wild-type (WT (show HSD11B1 Proteins)) mice. However, no differences were observed in the apoA-I levels.

  6. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha (show TNF Proteins) activity, which may explain neuroinflammation in septic mouse brain.

  7. MMP-13 (show MMP13 Proteins) prevails over MMP-8 in collagen degradation in atheromata.

  8. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10 (show ADAM10 Proteins), N-cadherin (show CDH2 Proteins), and beta-catenin (show CTNNB1 Proteins)-mediated pathway and plays an important role in neointima formation.

  9. Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo.

  10. MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions.

Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. Sputum, serum, and urine MMP-8 were not significantly changed in COPD (show ARCN1 Proteins) exacerbation compared to recovery values.

  2. EMMPRIN, MMP8, hyaluronan, beta-defensing-2, and neutrophil gelatinase-associated lipocalin (NGAL (show LCN2 Proteins)) are elevated in women with vaginal inflammation

  3. Suggest that MMP-8 polymorphism -799 C/T was a risk for developing chronic periapical lesions.

  4. The reciprocal positive interplay between MMP-8 and TGF-beta1 contributes to HCC invasion and metastasis by inducing EMT mainly through the PI3K/Akt/Rac1 pathway.

  5. increased levels in saliva (show RAG1AP1 Proteins) and serum in women with polycystic ovary syndrome, and is potentiated in the presence of gingivitis

  6. Positive results of the aMMP-8 test significantly correlate with generalized ChP (show CHP Proteins). The aMMP-8 test may be used by physicians to detect periodontitis in their patients.

  7. miR (show MLXIP Proteins)-539 plays a key role in inhibiting osteosarcoma cell invasion and migration and can regulate MMP8 expression in osteosarcoma cells.

  8. salivary levels of the analyzed biomarkers MMP-8, -9, MPO (show MPO Proteins) are associated with periodontal status. However, these biomarkers could not differentiate between patients with or without a MI.

  9. Moderate-strength STS (show STS Proteins) causes the highest TIMP-1 (show TIMP1 Proteins)/MMP-8 ratio, leading to appropriate conditions for reformation of the extracellular matrix

  10. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 (show MMP1 Proteins) and -8 in tuberculosis, but MMP-8 was a better discriminator for TB in men.

MMP8 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP8

  • matrix metallopeptidase 8 (neutrophil collagenase) (MMP8)
  • matrix metallopeptidase 8 (Mmp8)
  • matrix metallopeptidase 8 (neutrophil collagenase) (Mmp8)
  • matrix metalloproteinase 8 (LOC100339790)
  • BB138268 protein
  • CLG1 protein
  • HNC protein
  • MMP-8 protein
  • MMP8 protein
  • PMNL-CL protein

Protein level used designations for MMP8

matrix metallopeptidase 8 (neutrophil collagenase) , matrix metalloproteinase 8 , MMP-8 , collagenase 2 , collagenase-2 , matrix metalloproteinase-8 , neutrophil collagenase , neutrophil collagenease , PMNL collagenase , matrix metalloproteinase 8 (neutrophil collagenase)

GENE ID SPECIES
740516 Pan troglodytes
17394 Mus musculus
63849 Rattus norvegicus
4317 Homo sapiens
100724670 Cavia porcellus
100339790 Oryctolagus cuniculus
Selected quality suppliers for MMP8 Proteins (MMP8)
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