Matrix Metallopeptidase 8 (Neutrophil Collagenase) Proteins (MMP8)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP8 Antibodies (181) and MMP8 Kits (92) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP8 17394 O70138
MMP8 63849 O88766
MMP8 4317 P22894
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Top MMP8 Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_CHO Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Mouse Un-conjugated 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
HOST_Human Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$195.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag   1 U Log in to see 2 to 3 Days
$190.93
Details

MMP8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,

Rat (Rattus) ,
,
Human , , , ,
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More Proteins for Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) Interaction Partners

Mouse (Murine) Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3 (show CLDN3 Proteins)

  2. These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression.

  3. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia.

  4. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.

  5. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.

  6. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin (show FMOD Proteins) and therefore increasing the bioavailability of TGF-beta (show TGFB1 Proteins).

  7. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL (show HSD11B1 Proteins) particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I (show APOA1 Proteins) levels.

  8. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha (show TNF Proteins) activity, which may explain neuroinflammation in septic mouse brain.

  9. MMP-13 (show MMP13 Proteins) prevails over MMP-8 in collagen degradation in atheromata.

  10. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10 (show ADAM10 Proteins), N-cadherin (show CDH2 Proteins), and beta-catenin (show CTNNB1 Proteins)-mediated pathway and plays an important role in neointima formation.

Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. Our study provides evidence for the tumour-suppressive mechanisms of MMP-8 in OTSCC by interplay with TGF-b1 and VEGF-C (show VEGFC Proteins).

  2. These results provide the first evidence that MMP8 SNP at the rs11225394 locus is associated with the increased risk of osteonecrosis of the femoral head in Chinese Han population.

  3. Low MMP-8/TIMP-1 (show TIMP1 Proteins) reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 (show TIMP1 Proteins) may help to differentiate it from acute coronary syndrome

  4. Plasma levels of MMP-1 (show MMP1 Proteins), MMP-8, and MMP-9 (show MMP9 Proteins) are associated with COPD (show ARCN1 Proteins) severity and can be used as a biomarker to better understand the characteristics of COPD (show ARCN1 Proteins) patients.

  5. there is a negative correlation between blood MMP8 and HDL (show HSD11B1 Proteins)-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in acne inversa

  6. plasma concentrations of MMP-7 (show MMP7 Proteins), MMP-8, -9 and TIMP-1 (show TIMP1 Proteins) within 96 h from the onset of acute pancreatitis symptoms are elevated in acute pancreatitis patients compared with healthy controls

  7. MMP-8 is a vital component of the myoepithelial tumour-suppressor function. It restores MEC (show CCL28 Proteins) interaction with the matrix, opposes TGF-beta (show TGFB1 Proteins) signalling and MMP-9 (show MMP9 Proteins) proteolysis, which contributes to inhibition of tumour cell invasion.

  8. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO (show MPO Proteins), CEACAM8, CRISP3 (show CRISP3 Proteins), MS4A3 (show MS4A3 Proteins), CEACAM6, HEMGN, and MMP8

  9. Obesity is associated with elevated circulating MMP-8 in young adults. MMP-8 is also increased in smokers.

  10. infiltrative pulmonary tuberculosis is characterized by impairements in the system MMP/inhibitors: the levels of MMP-1 (show MMP1 Proteins), -9 increased, MMP-3 (show MMP3 Proteins), -8, TIMP-1 (show TIMP1 Proteins) remained at the reference values and a 2-macroglobulin was low.

MMP8 Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP8

  • matrix metallopeptidase 8 (neutrophil collagenase) (MMP8)
  • matrix metallopeptidase 8 (Mmp8)
  • matrix metallopeptidase 8 (neutrophil collagenase) (Mmp8)
  • matrix metalloproteinase 8 (LOC100339790)
  • BB138268 protein
  • CLG1 protein
  • HNC protein
  • MMP-8 protein
  • MMP8 protein
  • PMNL-CL protein

Protein level used designations for MMP8

matrix metallopeptidase 8 (neutrophil collagenase) , matrix metalloproteinase 8 , MMP-8 , collagenase 2 , collagenase-2 , matrix metalloproteinase-8 , neutrophil collagenase , neutrophil collagenease , PMNL collagenase , matrix metalloproteinase 8 (neutrophil collagenase)

GENE ID SPECIES
740516 Pan troglodytes
17394 Mus musculus
63849 Rattus norvegicus
4317 Homo sapiens
100724670 Cavia porcellus
100339790 Oryctolagus cuniculus
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