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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP2 Kits (121) and MMP2 Proteins (45) and many more products for this protein.
Showing 10 out of 371 products:
Chicken Polyclonal MMP2 Primary Antibody for ICC, IF - ABIN152329
Krekoski, Neubauer, Graham, Muir: Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
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Human Monoclonal MMP2 Primary Antibody for ICC, IHC (fro) - ABIN152258
Locke, Royce, Wainewright, Samuel, Tang: Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. in American journal of respiratory cell and molecular biology 2007
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Human Monoclonal MMP2 Primary Antibody for Func, IHC (p) - ABIN180364
Soini, Hurskainen, Höyhtyä, Oikarinen, Autio-Harmainen: 72 KD and 92 KD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994
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Human Monoclonal MMP2 Primary Antibody for IHC (p), IP - ABIN180365
Autio-Harmainen, Karttunen, Hurskainen, Höyhtyä, Kauppila, Tryggvason: Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors. in Laboratory investigation, a journal of technical methods and pathology 1993
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Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN707426
Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014
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Guinea Pig Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN152257
Rork, Hadzimichalis, Kappil, Merrill: Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. in Journal of molecular and cellular cardiology 2006
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Human Polyclonal MMP2 Primary Antibody for WB - ABIN657616
Shi, Shang, Pan, Wang, Jiang, Hao, Zhang, Cai, Xu, Zhan, Wang: Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1 expression via STAT5A. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
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Human Monoclonal MMP2 Primary Antibody for ELISA, WB - ABIN1098146
Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. in British journal of cancer 2012
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Human Polyclonal MMP2 Primary Antibody for ELISA, WB - ABIN1533350
Matsumoto, Niimi, Kohyama: Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis. in Cellular immunology 2012
Cow (Bovine) Polyclonal MMP2 Primary Antibody for IHC, WB - ABIN2792308
Collier, Wilhelm, Eisen, Marmer, Grant, Seltzer, Kronberger, He, Bauer, Goldberg: H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. in The Journal of biological chemistry 1988
study demonstrated that matrix metalloproteinase 1 (show MMP1 Antibodies) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (show CA2 Antibodies)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (show WNT4 Antibodies) signaling antagonist, MMP2 cleaves the glypican (show GPC1 Antibodies), reducing the ability of Dlp (show DMD Antibodies) to interact with the Wnt (show WNT4 Antibodies) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (show ADCY10 Antibodies) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (show MMP9 Antibodies) in the embryonic zebrafish.
Identify novel MMP-2/cardiac sPLA2 (show PLA2G2A Antibodies) pathway that endows the heart with important endocrine functions, including regulation of inflammation and lipid metabolism in the liver.
129/SvEv mice are more susceptible to abdominal aortic aneurysms compared to C57Bl/6 mice and suggest roles for MMP2/9.
Report cross-talk between macrophages, smooth muscle cells, and endothelial cells in response to cigarette smoke alters MMP2/9 levels.
MMP-2 silenced hypoxic fibroblasts under hyperglycemic conditions have impaired angiogenic potential. Collagen I/IV secretion is decreased and cell migration is prevented.
N-terminal truncated isoform-MMP-2, but not full-length-MMP-2, is the major isoform of MMP-2 involved in skeletal muscle Ischemia-reperfusion injury.
These data indicate that oxygen-glucose deprivation-triggered Cav-1 (show CAV1 Antibodies) S-nitrosylation interacts with tPA (show PLAT Antibodies)-induced ERK (show EPHB2 Antibodies) activation to augment MMP2 and 9 secretion and subsequent extracellular matrix degradation.
Type IV collagenases, MMP-2 and MMP-9 (show MMP9 Antibodies), play important roles in hair cycle, and this could be mediated by induced expression of VEGF (show VEGFA Antibodies), IGF-1 (show IGF1 Antibodies), and TGF-beta (show TGFB1 Antibodies).
Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction
Early MMP-2/MMP-9 (show MMP9 Antibodies) activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse.
Taken together, these findings indicate for the first time that AnxA2 (show ANXA2 Antibodies) phosphorylation and actin remodeling evoked by oxidative stress depend on the sphingolipid pathway, via MMP2 and p38MAPK (show MAPK14 Antibodies).
MMP2 mutations are associated with multicentric osteolysis nodulosis and arthropathy.
it was also observed that miR-7 (show LILRB1 Antibodies) regulated the proliferation and migration of colon cancer by regulating the protein expression of FAK (show PTK2 Antibodies), therefore, regulating the expression of matrix metalloproteinase (MMP)-2 and MMP-9 (show MMP9 Antibodies)
These findings demonstrate that Tan-IIA inhibits the migration ability of AGS (show JAG1 Antibodies) human gastric cancer cells and that decreasing the protein expression of NF-kappaB (show NFKB1 Antibodies)-p65 (show GORASP1 Antibodies), COX-2 (show COX2 Antibodies), and MMP-2, -7 and -9 may be an underlying molecular mechanism
Resveratrol inhibited hypoxia-induced HIF-1alpha (show HIF1A Antibodies) protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (show PRAP1 Antibodies) and MMP2.
this study shows that miR (show MLXIP Antibodies)-124-3p may negatively regulate the transcription of the STAT3 (show STAT3 Antibodies) by interfering with its 3'UTR (show UTS2R Antibodies), and the degradation of STAT3 (show STAT3 Antibodies) affects its downstream expression of such as p-STAT3 (show STAT3 Antibodies), CCND2 (show CCND2 Antibodies) and MMP-2
GnRH (show GNRH1 Antibodies) regulates trophoblast invasion via RUNX2 (show RUNX2 Antibodies)-mediated MMP2/MMP9 (show MMP9 Antibodies) expression.
Cerebrospinal fluid (CSF (show CSF2 Antibodies)) levels of IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), IL-10 (show IL10 Antibodies), MMP-2 and MMP-9 (show MMP9 Antibodies) were significantly higher in patients with acute transverse myelitis; CSF (show CSF2 Antibodies) IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) were significantly associated with severity of the disease
Cox (show COX8A Antibodies) analysis of MMP-2 and -9 were significant independent predictors of disease-free survival in colorectal carcinoma.
Independent prognostic value of MMP-2 expression in ovarian cancer is limited to a role in PFS for epithelial MMP-2 expression.
These results suggest that the PEG (show PAEP Antibodies)-SS-Ce6-MMP2 nanoparticles hold great potential for tumor-targeting imaging and photodynamic therapy
The results showed that a decrease in MMP-1 (show MMP1 Antibodies) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (show MMP9 Antibodies) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (show PKCa Antibodies) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (show MMP14 Antibodies)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase (show CA-P60A Antibodies) activity, but the pretreatment with TIMP-2 (show TIMP2 Antibodies) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (show MMP14 Antibodies), MMP-2 and TIMP-2 (show TIMP2 Antibodies) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
Results describe distinct changes in expression of MMP2, MMP14 (show MMP14 Antibodies), and the metallopeptidase (show ECEL1 Antibodies) inhibitor TIMP2 (show TIMP2 Antibodies) between different phases of the estrous cycle indicating an endocrine regulation.
EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 and MMP-14 (show MMP14 Antibodies) suggesting a role in adhesion and fusion of embryo to luminal epithelium.
High shear stress up-regulates type IV collagen (show COL4 Antibodies) synthesis and down-regulates MMP-2 secretion in endothelial cells.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Antibodies), TIMP1 (show TIMP1 Antibodies), and NGAL (show LCN2 Antibodies) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (show MMP9 Antibodies) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Antibodies) and MMP-2, caspase-3 (show CASP3 Antibodies) and BDNF (show BDNF Antibodies)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (show MMP14 Antibodies) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Antibodies) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (show MMP9 Antibodies) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Antibodies), pro-MMP-9 (show MMP9 Antibodies), MMP-2, VEGFR-1 (show FLT1 Antibodies), VEGFR-2 (show KDR Antibodies), and TIMP-1 (show TIMP1 Antibodies), which may contribute to the development of venous stenosis.
Inflammatory factors such as TNF-alpha (show TNF Antibodies) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (show DMD Antibodies).
Castor (show CASZ1 Antibodies) oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (show AMBP Antibodies) effectively inhibited the increased expression of MMP-2, MMP-3 (show MMP3 Antibodies), and iNOS (show NOS2 Antibodies) in degenerated NP cells induced by IL-1beta (show IL1B Antibodies) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (show MMP9 Antibodies) and TIMP-1 (show TIMP1 Antibodies) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 (show COX2 Antibodies) can effectively inhibit the expression of COX-2 (show COX2 Antibodies) and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)